Induction of fragility at the human RNU2 locus by cytosine arabinoside is dependent upon a transcriptionally competent U2 small nuclear RNA gene and the expression of p53

Chromosomal fragile sites are regions that are intrinsically unstable and are susceptible to experimentally induced damage. In most cases, the target and mechanism of induction of fragility are unknown. Using ectopic integration of engineered DNA arrays to create "new" fragile sites, we an...

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Veröffentlicht in:	Somatic cell and molecular genetics 1997-11, Vol.23 (6), p.379-389
Hauptverfasser:	MacArthur, H L, Agarwal, M L, Bacchetti, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimetabolites, Antineoplastic - pharmacology Chromosome Fragile Sites Chromosome Fragility Cytarabine - pharmacology DNA - drug effects Humans RNA, Small Nuclear - drug effects RNA, Small Nuclear - genetics RNA, Small Nuclear - metabolism Transcription, Genetic Tumor Suppressor Protein p53 - metabolism
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