Chromostatin Inhibits Catecholamine Secretion in Adrenal Chromaffin Cells by Activating a Protein Phosphatase

Chromostatin is a 20-residue peptide derived from chromogranin A (CGA), the major soluble component of secretory granules in adrenal medullary chromaffin cells. One known biological function of chromostatin is to inhibit the secretagogue-evoked catecholamine secretion from chromaffin cells. Putative...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1992-08, Vol.89 (16), p.7398-7402
Hauptverfasser:	Galindo, Estelle, Zwiller, Jean, Bader, Marie-France, Aunis, Dominique
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Medulla - drug effects Adrenal Medulla - enzymology Adrenal Medulla - physiology Adrenals. Interrenals Adrenomedullary hormones. Regulation Animals Biological and medical sciences Calcium - metabolism Catecholamines Cattle Cells, Cultured Cellular biology Chromaffin cells Chromogranin A Chromogranins - pharmacology Cultured cells Cyclic nucleotides Enzyme Activation Enzymes Ethers, Cyclic - pharmacology Fundamental and applied biological sciences. Psychology Kinetics Lasalocid - pharmacology Norepinephrine - metabolism Okadaic Acid P type calcium channels Peptide Fragments - pharmacology Phosphatases Phosphoprotein Phosphatases - metabolism Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Proteins Rats Receptors Secretion Ungulates Vertebrates: endocrinology
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