Sodium channel blockade unmasks two temporally distinct mechanisms of striatal dopamine release during hypoxia/hypoglycaemia in vitro

Massive striatal dopamine release during cerebral ischaemia has been implicated in the resulting neuronal damage. Sodium influx is an early event in the biochemical cascade during ischaemia and blockade of sodium channels may increase resistance to ischaemia by reducing energy demand involved in com...

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Veröffentlicht in:	Neuroscience 1997-12, Vol.81 (4), p.999-1007
Hauptverfasser:	Toner, C.C, Stamford, J.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors dopamine Dopamine - metabolism Electrophysiology Extracellular Space - drug effects Extracellular Space - metabolism Fundamental and applied biological sciences. Psychology Hypoglycemia - metabolism Hypoxia, Brain - metabolism hypoxia/hypoglycaemia In Vitro Techniques Lidocaine - pharmacology Male Neostriatum - metabolism Phenytoin - pharmacology Rats Rats, Wistar Sodium Channel Blockers sodium channels striatum tetrodotoxin Tetrodotoxin - pharmacology veratridine Vertebrates: nervous system and sense organs
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