Hydroxylated 2,4-diphenyl indenopyridine derivatives as a selective non-intercalative topoisomerase IIα catalytic inhibitor

For the development of novel anticancer agents, we designed and synthesized hydroxylated 2,4-diphenyl indenopyridines, and evaluated their topoisomerase inhibitory activity as well as their antiproliferative activities against several human cancer cell lines. The structure–activity relationship stud...

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Veröffentlicht in:	European journal of medicinal chemistry 2015-01, Vol.90, p.302-314
Hauptverfasser:	Kadayat, Tara Man, Park, Chanmi, Jun, Kyu-Yeon, Thapa Magar, Til Bahadur, Bist, Ganesh, Yoo, Han Young, Kwon, Youngjoo, Lee, Eung-Seok
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer agents Antigens, Neoplasm - metabolism Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antiproliferative activity Biocatalysis Cell Line, Tumor Cell Proliferation - drug effects DNA Topoisomerases, Type II - metabolism DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - metabolism Dose-Response Relationship, Drug Drug Screening Assays, Antitumor HeLa Cells Humans Hydroxylated 2,4-diphenyl indenopyridine Hydroxylation Indenes - chemical synthesis Indenes - chemistry Indenes - pharmacology Molecular Structure Pyridines - chemical synthesis Pyridines - chemistry Pyridines - pharmacology Structure-Activity Relationship Terpyridine Topoisomerase II Inhibitors - chemical synthesis Topoisomerase II Inhibitors - chemistry Topoisomerase II Inhibitors - pharmacology Topoisomerase IIα non-intercalative catalytic inhibitor
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