A meta-analysis of cognitive functions in children and adolescents with major depressive disorder
The cumulative prevalence rates of major depressive disorders (MDD) in children and adolescents averages 9.5 %. The majority of adults with MDD suffer from significant cognitive deficits, but the available neuropsychological data on the cognitive performance of children and adolescents with MDD yiel...
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| Veröffentlicht in: | European child & adolescent psychiatry 2015-01, Vol.24 (1), p.5-19 |
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| creator | Wagner, Stefanie Müller, Carmen Helmreich, Isabella Huss, Michael Tadić, André |
| description | The cumulative prevalence rates of major depressive disorders (MDD) in children and adolescents averages 9.5 %. The majority of adults with MDD suffer from significant cognitive deficits, but the available neuropsychological data on the cognitive performance of children and adolescents with MDD yielded mixed results. Meta-analytic methods were used to assess the severity of cognitive deficits in children and adolescents with MDD as compared to healthy children and adolescents. We identified 17 studies comparing the intelligence, executive functions, verbal memory and attention of 447 patients with DSM-IV MDD and 1,347 healthy children and adolescents. Children and adolescents with MDD performed 0.194–0.772 (
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| doi_str_mv | 10.1007/s00787-014-0559-2 |
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p
< 0.001) standard mean differences worse than healthy control subjects in neuropsychological test procedures. The most pronounced deficits of children and adolescents with MDD were seen in inhibition capacity (STD = 0.772;
p
= 0.002), phonemic verbal fluency (STD = 0.756;
p
= 0.0001), sustained attention (STD = 0.522;
p
= 0.000), verbal memory (STD = 0.516;
p
= 0.0009) and planning (STD = 0.513;
p
= 0.014). We revealed cognitive deficits of children and adolescents with MDD in various cognitive domains. Long-term studies should investigate how the cognitive deficits of depressed youth affect their academic and social functioning, and whether age, comorbidity and depression severity play a role in this process.</description><identifier>ISSN: 1018-8827</identifier><identifier>EISSN: 1435-165X</identifier><identifier>DOI: 10.1007/s00787-014-0559-2</identifier><identifier>PMID: 24869711</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Case-Control Studies ; Child ; Child and Adolescent Psychiatry ; Cognition - physiology ; Cognition Disorders - physiopathology ; Depressive Disorder, Major - physiopathology ; Depressive Disorder, Major - psychology ; Humans ; Medicine ; Medicine & Public Health ; Neuropsychological Tests ; Psychiatry ; Review ; Systematic review</subject><ispartof>European child & adolescent psychiatry, 2015-01, Vol.24 (1), p.5-19</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-7f719748c7b2e13eb6f2bef4f1f74e460f5b6ddff49231096aa47bcd2dcd7cc13</citedby><cites>FETCH-LOGICAL-c405t-7f719748c7b2e13eb6f2bef4f1f74e460f5b6ddff49231096aa47bcd2dcd7cc13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00787-014-0559-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00787-014-0559-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,12826,27902,27903,30977,41466,42535,51296</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24869711$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wagner, Stefanie</creatorcontrib><creatorcontrib>Müller, Carmen</creatorcontrib><creatorcontrib>Helmreich, Isabella</creatorcontrib><creatorcontrib>Huss, Michael</creatorcontrib><creatorcontrib>Tadić, André</creatorcontrib><title>A meta-analysis of cognitive functions in children and adolescents with major depressive disorder</title><title>European child & adolescent psychiatry</title><addtitle>Eur Child Adolesc Psychiatry</addtitle><addtitle>Eur Child Adolesc Psychiatry</addtitle><description>The cumulative prevalence rates of major depressive disorders (MDD) in children and adolescents averages 9.5 %. The majority of adults with MDD suffer from significant cognitive deficits, but the available neuropsychological data on the cognitive performance of children and adolescents with MDD yielded mixed results. Meta-analytic methods were used to assess the severity of cognitive deficits in children and adolescents with MDD as compared to healthy children and adolescents. We identified 17 studies comparing the intelligence, executive functions, verbal memory and attention of 447 patients with DSM-IV MDD and 1,347 healthy children and adolescents. Children and adolescents with MDD performed 0.194–0.772 (
p
< 0.001) standard mean differences worse than healthy control subjects in neuropsychological test procedures. The most pronounced deficits of children and adolescents with MDD were seen in inhibition capacity (STD = 0.772;
p
= 0.002), phonemic verbal fluency (STD = 0.756;
p
= 0.0001), sustained attention (STD = 0.522;
p
= 0.000), verbal memory (STD = 0.516;
p
= 0.0009) and planning (STD = 0.513;
p
= 0.014). We revealed cognitive deficits of children and adolescents with MDD in various cognitive domains. Long-term studies should investigate how the cognitive deficits of depressed youth affect their academic and social functioning, and whether age, comorbidity and depression severity play a role in this process.</description><subject>Adolescent</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child and Adolescent Psychiatry</subject><subject>Cognition - physiology</subject><subject>Cognition Disorders - physiopathology</subject><subject>Depressive Disorder, Major - physiopathology</subject><subject>Depressive Disorder, Major - psychology</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neuropsychological Tests</subject><subject>Psychiatry</subject><subject>Review</subject><subject>Systematic review</subject><issn>1018-8827</issn><issn>1435-165X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kE1rHSEUhqU0NGmSH9BNEbLpxkQdP2aWIfQLAt0kkJ04eky8zOitzqTk39ebm5YS6MYjnOd9lQehD4yeM0r1RW1HrwllglApB8LfoCMmOkmYkndv252ynvQ914fofa0bSpkcKH-HDrno1aAZO0L2Es-wWGKTnZ5qrDgH7PJ9ikt8BBzW5JaYU8UxYfcQJ18gYZs8tj5PUB2kpeJfcXnAs93kgj1sC9S6y_pYc_FQTtBBsFOF05d5jG6_fL65-kauf3z9fnV5TZygciE6aDZo0Ts9cmAdjCrwEYIILGgBQtEgR-V9CGLgHaODslbo0XnundfOse4Yfdr3bkv-uUJdzBzbB6fJJshrNUwJyTuqhq6hZ6_QTV5LM_BMCTkoKWSj2J5yJddaIJhtibMtT4ZRs_Nv9v5N8292_g1vmY8vzes4g_-b-CO8AXwP1LZK91D-efq_rb8BkDmRng</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Wagner, Stefanie</creator><creator>Müller, Carmen</creator><creator>Helmreich, Isabella</creator><creator>Huss, Michael</creator><creator>Tadić, André</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7QJ</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HEHIP</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2R</scope><scope>M2S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20150101</creationdate><title>A meta-analysis of cognitive functions in children and adolescents with major depressive disorder</title><author>Wagner, Stefanie ; Müller, Carmen ; Helmreich, Isabella ; Huss, Michael ; Tadić, André</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-7f719748c7b2e13eb6f2bef4f1f74e460f5b6ddff49231096aa47bcd2dcd7cc13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child and Adolescent Psychiatry</topic><topic>Cognition - physiology</topic><topic>Cognition Disorders - physiopathology</topic><topic>Depressive Disorder, Major - physiopathology</topic><topic>Depressive Disorder, Major - psychology</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neuropsychological Tests</topic><topic>Psychiatry</topic><topic>Review</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wagner, Stefanie</creatorcontrib><creatorcontrib>Müller, Carmen</creatorcontrib><creatorcontrib>Helmreich, Isabella</creatorcontrib><creatorcontrib>Huss, Michael</creatorcontrib><creatorcontrib>Tadić, André</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Sociology Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Social Science Database</collection><collection>Sociology Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European child & adolescent psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wagner, Stefanie</au><au>Müller, Carmen</au><au>Helmreich, Isabella</au><au>Huss, Michael</au><au>Tadić, André</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A meta-analysis of cognitive functions in children and adolescents with major depressive disorder</atitle><jtitle>European child & adolescent psychiatry</jtitle><stitle>Eur Child Adolesc Psychiatry</stitle><addtitle>Eur Child Adolesc Psychiatry</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>24</volume><issue>1</issue><spage>5</spage><epage>19</epage><pages>5-19</pages><issn>1018-8827</issn><eissn>1435-165X</eissn><abstract>The cumulative prevalence rates of major depressive disorders (MDD) in children and adolescents averages 9.5 %. The majority of adults with MDD suffer from significant cognitive deficits, but the available neuropsychological data on the cognitive performance of children and adolescents with MDD yielded mixed results. Meta-analytic methods were used to assess the severity of cognitive deficits in children and adolescents with MDD as compared to healthy children and adolescents. We identified 17 studies comparing the intelligence, executive functions, verbal memory and attention of 447 patients with DSM-IV MDD and 1,347 healthy children and adolescents. Children and adolescents with MDD performed 0.194–0.772 (
p
< 0.001) standard mean differences worse than healthy control subjects in neuropsychological test procedures. The most pronounced deficits of children and adolescents with MDD were seen in inhibition capacity (STD = 0.772;
p
= 0.002), phonemic verbal fluency (STD = 0.756;
p
= 0.0001), sustained attention (STD = 0.522;
p
= 0.000), verbal memory (STD = 0.516;
p
= 0.0009) and planning (STD = 0.513;
p
= 0.014). We revealed cognitive deficits of children and adolescents with MDD in various cognitive domains. Long-term studies should investigate how the cognitive deficits of depressed youth affect their academic and social functioning, and whether age, comorbidity and depression severity play a role in this process.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24869711</pmid><doi>10.1007/s00787-014-0559-2</doi><tpages>15</tpages></addata></record> |
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| subjects | Adolescent Case-Control Studies Child Child and Adolescent Psychiatry Cognition - physiology Cognition Disorders - physiopathology Depressive Disorder, Major - physiopathology Depressive Disorder, Major - psychology Humans Medicine Medicine & Public Health Neuropsychological Tests Psychiatry Review Systematic review |
| title | A meta-analysis of cognitive functions in children and adolescents with major depressive disorder |
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