Development of potent gastrin-releasing peptide antagonists having a D-Pro- psi (CH sub(2)NH)-Phe-NH sub(2) C terminus

Gastrin-releasing peptide (GRP) is a 27-amino acid neuroendocrine hormone that may play a role in the pathophysiology of small cell lung carcinoma. GRP and bombesin, a structurally related peptide, stimulate the growth of some cultured cell types. C-terminal GRP peptide analogs were developed that i...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1993-01, Vol.90 (5), p.1922-1926
Hauptverfasser:	Leban, J J, Kull, FC Jr, Landavazo, A, Stockstill, B, McDermed, J D
Format:	Artikel
Sprache:	eng
Schlagworte:	antagonists gastric-releasing peptide properties synthesis
Online-Zugang:	Volltext
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