Synthesis and Stability of Four Maleimide Derivatives of the Anticancer Drug Doxorubicin for the Preparation of Chemoimmunoconjugates

By attaching maleimide groups to anticancer drugs, derivatives are obtained which bind selectively to thiolated carrier proteins. Four maleimide derivatives of the anticancer drug doxorubicin were prepared in which 3-maleimidobenzoic acid or 4-maleimidophenylacetic acid was bound to the 3'-amin...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1997/02/15, Vol.45(2), pp.399-401
Hauptverfasser:	KRUGER, Michael, BEYER, Ulrich, SCHUMACHER, Peter, UNGER, Clemens, ZAHN, Heike, KARTZ, Felix
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences chemoimmunoconjugate doxorubicin maleimide derivative Medical sciences Miscellaneous. Antibiotics with multiple activities Pharmacology. Drug treatments stability
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