Functional analysis of the amino-terminal 8-kDa domain of DNA polymerase beta as revealed by site-directed mutagenesis. DNA binding and 5'-deoxyribose phosphate lyase activities

The amino-terminal 8-kDa domain of DNA polymerase beta functions in binding single-stranded DNA (ssDNA), recognition of a 5'-phosphate in gapped DNA structures, and as a 5'-deoxyribose phosphate (dRP) lyase. NMR and x-ray crystal structures of this domain have suggested several residues th...

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Veröffentlicht in:	The Journal of biological chemistry 1998-05, Vol.273 (18), p.11121-11126
Hauptverfasser:	Prasad, R, Beard, W A, Chyan, J Y, Maciejewski, M W, Mullen, G P, Wilson, S H
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Circular Dichroism DNA Polymerase beta - chemistry DNA Polymerase beta - genetics DNA Polymerase beta - metabolism DNA, Single-Stranded - metabolism Escherichia coli - genetics Lyases - metabolism Mutagenesis, Site-Directed Protein Binding Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism
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