Neocarzinostatin-induced mutations at the hprt locus in exponentially growing CHO cells, compared with spontaneous mutations

Spontaneous mutations and neocarzinostatin-induced mutations were investigated in the hypoxanthine-guanine phosphoribosyltransferase (hprt) gene in exponentially growing Chinese hamster ovary cells. Neocarzinostatin (NCS) treatment caused an 4.5-fold increase in mutation frequency. Analysis by multi...

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Veröffentlicht in:	Carcinogenesis (New York) 1998-05, Vol.19 (5), p.791-796
Hauptverfasser:	KIMURA, H, TAKADA, T, SHINGU, Y, KATO, Y, IYEHARA-OGAWA, H, TERADO, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - pharmacology Biological and medical sciences CHO Cells Cricetinae Drug toxicity and drugs side effects treatment Hypoxanthine Phosphoribosyltransferase - genetics Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Mutation Pharmacology. Drug treatments Polymerase Chain Reaction RNA Splicing Sequence Deletion Zinostatin - pharmacology
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