Compounds selective for dopamine receptor subtypes

Novel dopamine (DA) receptor proteins of relatively low natural abundance and uncertain physiology can be expressed selectively in genetically transfected cultured cells to facilitate screening of novel DA receptor ligands. Selective agonists or antagonists for most of the five major DA receptor typ...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Drug discovery today 1997-08, Vol.2 (8), p.333-340
Hauptverfasser:	Kebabian, John W., Tarazi, Frank I., Kula, Nora S., Baldessarini, Ross J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Catecholaminergic system Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page	340
container_issue	8
container_start_page	333
container_title	Drug discovery today
container_volume	2
creator	Kebabian, John W. Tarazi, Frank I. Kula, Nora S. Baldessarini, Ross J.
description	Novel dopamine (DA) receptor proteins of relatively low natural abundance and uncertain physiology can be expressed selectively in genetically transfected cultured cells to facilitate screening of novel DA receptor ligands. Selective agonists or antagonists for most of the five major DA receptor types are emerging, but better D 4 and D 5 agonists, D 3 and D 5 antagonists, and more selective D 2 antagonists are needed. Clinical development of such compounds as diagnostic neuroradiopharmaceuticals or neuropsychiatric drugs remains empirical and somewhat unpredictable. The search for novel receptor-selective agents can be enhanced by better understanding of the physiology and pharmacology of DA neuroreceptors.
doi_str_mv	10.1016/S1359-6446(97)01075-1
format	Article
fullrecord	<record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_16441690</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1359644697010751</els_id><sourcerecordid>16441690</sourcerecordid><originalsourceid>FETCH-LOGICAL-c367t-a4db325714341f8344c5a6834d5991ae27c536e3c7c70c7a4c09376f919530583</originalsourceid><addsrcrecordid>eNqFUMtKBDEQDKLguvoJwhxE9DCanrwmJ5HFFyx4UM8hm-mByLxMZhb8e7MPvXqqpqnqripCzoHeAAV5-wZM6FxyLq-0uqZAlcjhgMygVGUuSlYcpvmXckxOYvykFAot5IwUi74d-qmrYhaxQTf6NWZ1H7KqH2zrO8wCOhzGtInTavweMJ6So9o2Ec_2OCcfjw_vi-d8-fr0srhf5o5JNeaWVytWCAWccahLxrkTViashNZgsVBOMInMKaeoU5Y7qpmStQYtGE225-Ryd3cI_deEcTStjw6bxnbYT9FAigNS00QUO6ILfYwBazME39rwbYCaTUNm25DZxDdamW1DBpLuYv_ARmebOtjO-fgnLhSnXG183O1omMKuPQYTncfOYeVTN6Opev_Pox8Cd3jL</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16441690</pqid></control><display><type>article</type><title>Compounds selective for dopamine receptor subtypes</title><source>ScienceDirect Journals (5 years ago - present)</source><creator>Kebabian, John W. ; Tarazi, Frank I. ; Kula, Nora S. ; Baldessarini, Ross J.</creator><creatorcontrib>Kebabian, John W. ; Tarazi, Frank I. ; Kula, Nora S. ; Baldessarini, Ross J.</creatorcontrib><description>Novel dopamine (DA) receptor proteins of relatively low natural abundance and uncertain physiology can be expressed selectively in genetically transfected cultured cells to facilitate screening of novel DA receptor ligands. Selective agonists or antagonists for most of the five major DA receptor types are emerging, but better D 4 and D 5 agonists, D 3 and D 5 antagonists, and more selective D 2 antagonists are needed. Clinical development of such compounds as diagnostic neuroradiopharmaceuticals or neuropsychiatric drugs remains empirical and somewhat unpredictable. The search for novel receptor-selective agents can be enhanced by better understanding of the physiology and pharmacology of DA neuroreceptors.</description><identifier>ISSN: 1359-6446</identifier><identifier>EISSN: 1878-5832</identifier><identifier>DOI: 10.1016/S1359-6446(97)01075-1</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Biological and medical sciences ; Catecholaminergic system ; Medical sciences ; Neuropharmacology ; Neurotransmitters. Neurotransmission. Receptors ; Pharmacology. Drug treatments</subject><ispartof>Drug discovery today, 1997-08, Vol.2 (8), p.333-340</ispartof><rights>1997 Elsevier Science Ltd. All rights reserved</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-a4db325714341f8344c5a6834d5991ae27c536e3c7c70c7a4c09376f919530583</citedby><cites>FETCH-LOGICAL-c367t-a4db325714341f8344c5a6834d5991ae27c536e3c7c70c7a4c09376f919530583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1359-6446(97)01075-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2740478$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Kebabian, John W.</creatorcontrib><creatorcontrib>Tarazi, Frank I.</creatorcontrib><creatorcontrib>Kula, Nora S.</creatorcontrib><creatorcontrib>Baldessarini, Ross J.</creatorcontrib><title>Compounds selective for dopamine receptor subtypes</title><title>Drug discovery today</title><description>Novel dopamine (DA) receptor proteins of relatively low natural abundance and uncertain physiology can be expressed selectively in genetically transfected cultured cells to facilitate screening of novel DA receptor ligands. Selective agonists or antagonists for most of the five major DA receptor types are emerging, but better D 4 and D 5 agonists, D 3 and D 5 antagonists, and more selective D 2 antagonists are needed. Clinical development of such compounds as diagnostic neuroradiopharmaceuticals or neuropsychiatric drugs remains empirical and somewhat unpredictable. The search for novel receptor-selective agents can be enhanced by better understanding of the physiology and pharmacology of DA neuroreceptors.</description><subject>Biological and medical sciences</subject><subject>Catecholaminergic system</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Pharmacology. Drug treatments</subject><issn>1359-6446</issn><issn>1878-5832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqFUMtKBDEQDKLguvoJwhxE9DCanrwmJ5HFFyx4UM8hm-mByLxMZhb8e7MPvXqqpqnqripCzoHeAAV5-wZM6FxyLq-0uqZAlcjhgMygVGUuSlYcpvmXckxOYvykFAot5IwUi74d-qmrYhaxQTf6NWZ1H7KqH2zrO8wCOhzGtInTavweMJ6So9o2Ec_2OCcfjw_vi-d8-fr0srhf5o5JNeaWVytWCAWccahLxrkTViashNZgsVBOMInMKaeoU5Y7qpmStQYtGE225-Ryd3cI_deEcTStjw6bxnbYT9FAigNS00QUO6ILfYwBazME39rwbYCaTUNm25DZxDdamW1DBpLuYv_ARmebOtjO-fgnLhSnXG183O1omMKuPQYTncfOYeVTN6Opev_Pox8Cd3jL</recordid><startdate>19970801</startdate><enddate>19970801</enddate><creator>Kebabian, John W.</creator><creator>Tarazi, Frank I.</creator><creator>Kula, Nora S.</creator><creator>Baldessarini, Ross J.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>19970801</creationdate><title>Compounds selective for dopamine receptor subtypes</title><author>Kebabian, John W. ; Tarazi, Frank I. ; Kula, Nora S. ; Baldessarini, Ross J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-a4db325714341f8344c5a6834d5991ae27c536e3c7c70c7a4c09376f919530583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Biological and medical sciences</topic><topic>Catecholaminergic system</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kebabian, John W.</creatorcontrib><creatorcontrib>Tarazi, Frank I.</creatorcontrib><creatorcontrib>Kula, Nora S.</creatorcontrib><creatorcontrib>Baldessarini, Ross J.</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Drug discovery today</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kebabian, John W.</au><au>Tarazi, Frank I.</au><au>Kula, Nora S.</au><au>Baldessarini, Ross J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Compounds selective for dopamine receptor subtypes</atitle><jtitle>Drug discovery today</jtitle><date>1997-08-01</date><risdate>1997</risdate><volume>2</volume><issue>8</issue><spage>333</spage><epage>340</epage><pages>333-340</pages><issn>1359-6446</issn><eissn>1878-5832</eissn><abstract>Novel dopamine (DA) receptor proteins of relatively low natural abundance and uncertain physiology can be expressed selectively in genetically transfected cultured cells to facilitate screening of novel DA receptor ligands. Selective agonists or antagonists for most of the five major DA receptor types are emerging, but better D 4 and D 5 agonists, D 3 and D 5 antagonists, and more selective D 2 antagonists are needed. Clinical development of such compounds as diagnostic neuroradiopharmaceuticals or neuropsychiatric drugs remains empirical and somewhat unpredictable. The search for novel receptor-selective agents can be enhanced by better understanding of the physiology and pharmacology of DA neuroreceptors.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><doi>10.1016/S1359-6446(97)01075-1</doi><tpages>8</tpages></addata></record>
fulltext	fulltext
identifier	ISSN: 1359-6446
ispartof	Drug discovery today, 1997-08, Vol.2 (8), p.333-340
issn	1359-6446 1878-5832
language	eng
recordid	cdi_proquest_miscellaneous_16441690
source	ScienceDirect Journals (5 years ago - present)
subjects	Biological and medical sciences Catecholaminergic system Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments
title	Compounds selective for dopamine receptor subtypes
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T17%3A26%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Compounds%20selective%20for%20dopamine%20receptor%20subtypes&rft.jtitle=Drug%20discovery%20today&rft.au=Kebabian,%20John%20W.&rft.date=1997-08-01&rft.volume=2&rft.issue=8&rft.spage=333&rft.epage=340&rft.pages=333-340&rft.issn=1359-6446&rft.eissn=1878-5832&rft_id=info:doi/10.1016/S1359-6446(97)01075-1&rft_dat=%3Cproquest_cross%3E16441690%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16441690&rft_id=info:pmid/&rft_els_id=S1359644697010751&rfr_iscdi=true