Cataractogenesis and lipid peroxidation in newborn rats treated with buthionine sulfoximine: Preventive actions of melatonin

The purpose of this study was to examine the influence of exogenously administered melatonin on cataract formation and lipid peroxidation in newborn rats treated with buthionine sulfoximine (BSO), a drug which inhibits the rate‐limiting enzyme in glutathione (GSH) synthesis, y‐glutamylcysteine synth...

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Veröffentlicht in:	Journal of pineal research 1997-04, Vol.22 (3), p.117-123
Hauptverfasser:	Li, Zhrong Ren, Reiter, Russel J., Fujimori, Osamu, Oh, Chang Seok, Duan, Yan Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Antioxidants - metabolism Antioxidants - pharmacology Biological and medical sciences Brain - drug effects Brain - metabolism Buthionine Sulfoximine - toxicity Cataract - chemically induced Cataract - metabolism Cataract - prevention & control cataractogenesis Enzyme Inhibitors - toxicity Free Radical Scavengers - pharmacology Glutamate-Cysteine Ligase - antagonists & inhibitors glutathione Glutathione - metabolism Kidney - drug effects Kidney - metabolism Lens diseases Lens, Crystalline - drug effects Lens, Crystalline - metabolism lipid peroxidation Lipid Peroxidation - drug effects Liver - drug effects Liver - metabolism Lung - drug effects Lung - metabolism malondialdehyde Malondialdehyde - metabolism Medical sciences melatonin Melatonin - metabolism Melatonin - pharmacology Ophthalmology Rats Time Factors
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