Mosquito feeding-induced enhancement of Cache Valley virus (Bunyaviridae) infection in mice
Cache Valley (CV) virus, an arthropod-borne bunyavirus, recently has emerged as a significant veterinary pathogen causing infertility and congenital malformations in North American ruminants. To investigate the role of vector feeding on CV infection, adult mice were injected subcutaneously with CV,...
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| Veröffentlicht in: | Journal of medical entomology 1998-05, Vol.35 (3), p.261-265 |
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| creator | Edwards, J.F. (Texas AandM University, College Station, TX.) Higgs, S Beaty, B.J |
| description | Cache Valley (CV) virus, an arthropod-borne bunyavirus, recently has emerged as a significant veterinary pathogen causing infertility and congenital malformations in North American ruminants. To investigate the role of vector feeding on CV infection, adult mice were injected subcutaneously with CV, CV and vector thorax extract (a source of vector saliva), or CV into the site of intense, noninfected-mosquito feeding. Mice did not become infected after injection of CV or CV and vector saliva, nor did they produce antibodies to CV. However, injection of CV into sites of mosquito feeding resulted in viremia and production of anti-CV antibody by 2 wk after infection. This enhancement of CV infection resulted after feeding by Aedes triseriatus (Say), Ae. aegypti (L.), or Culex pipiens (L.). Enhancement occurred when injection was delayed up to 4 h after mosquito feeding, but it was not observed when virus injection was performed at a site distant from mosquito feeding. These results indicate that arbovirus infection may be enhanced by mosquito-vertebrate host interactions and that replication of arboviruses in arthropod vectors may not be responsible for increased virulence of infections mediated by infected arthropods. Enhanced CV infection in pregnant mice did not result in infertility or malformed pups, indicating that the mouse is not a suitable model to study CV-induced malformations |
| doi_str_mv | 10.1093/jmedent/35.3.261 |
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(Texas AandM University, College Station, TX.) ; Higgs, S ; Beaty, B.J</creator><creatorcontrib>Edwards, J.F. (Texas AandM University, College Station, TX.) ; Higgs, S ; Beaty, B.J</creatorcontrib><description>Cache Valley (CV) virus, an arthropod-borne bunyavirus, recently has emerged as a significant veterinary pathogen causing infertility and congenital malformations in North American ruminants. To investigate the role of vector feeding on CV infection, adult mice were injected subcutaneously with CV, CV and vector thorax extract (a source of vector saliva), or CV into the site of intense, noninfected-mosquito feeding. Mice did not become infected after injection of CV or CV and vector saliva, nor did they produce antibodies to CV. However, injection of CV into sites of mosquito feeding resulted in viremia and production of anti-CV antibody by 2 wk after infection. This enhancement of CV infection resulted after feeding by Aedes triseriatus (Say), Ae. aegypti (L.), or Culex pipiens (L.). Enhancement occurred when injection was delayed up to 4 h after mosquito feeding, but it was not observed when virus injection was performed at a site distant from mosquito feeding. These results indicate that arbovirus infection may be enhanced by mosquito-vertebrate host interactions and that replication of arboviruses in arthropod vectors may not be responsible for increased virulence of infections mediated by infected arthropods. Enhanced CV infection in pregnant mice did not result in infertility or malformed pups, indicating that the mouse is not a suitable model to study CV-induced malformations</description><identifier>ISSN: 0022-2585</identifier><identifier>EISSN: 1938-2928</identifier><identifier>DOI: 10.1093/jmedent/35.3.261</identifier><identifier>PMID: 9615544</identifier><identifier>CODEN: JMENA6</identifier><language>eng</language><publisher>Lanham, MD: Entomological Society of America</publisher><subject>Aedes ; AEDES AEGYPTI ; AEDES TRISERIATUS ; Animals ; Arthropod Vectors ; Biological and medical sciences ; Bunyamwera virus ; BUNYAVIRIDAE ; Bunyaviridae Infections - transmission ; Bunyaviridae Infections - virology ; COMPORTEMENT ALIMENTAIRE ; Culex ; CULEX PIPIENS ; Culicidae ; DISEASE MODELS ; Disease Models, Animal ; DISEASE VECTORS ; Eating ; FEEDING HABITS ; Fertility ; Fundamental and applied biological sciences. Psychology ; GESTACION ; GESTATION ; HABITOS ALIMENTARIOS ; HEMATOPHAGY ; INFECCION ; INFECTION ; Insect Bites and Stings ; Medically important nuisances and vectors, pests of stored products and materials: population survey and control ; MICE ; MODELE ; MODELOS ; PATHOGENESE ; PATHOGENESIS ; PATOGENESIS ; PREGNANCY ; RATON ; SOURIS ; VECTEUR DE MALADIE ; VECTOR ENHANCE INFECTION ; VECTORES ; VECTORS ; Vectors. Intermediate hosts ; Viremia - transmission ; Viremia - virology</subject><ispartof>Journal of medical entomology, 1998-05, Vol.35 (3), p.261-265</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-895fbcdb330557c97a16d56cd2f149b362515c4e529dbf4756a64b4c603be42f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2316551$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9615544$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Edwards, J.F. (Texas AandM University, College Station, TX.)</creatorcontrib><creatorcontrib>Higgs, S</creatorcontrib><creatorcontrib>Beaty, B.J</creatorcontrib><title>Mosquito feeding-induced enhancement of Cache Valley virus (Bunyaviridae) infection in mice</title><title>Journal of medical entomology</title><addtitle>J Med Entomol</addtitle><description>Cache Valley (CV) virus, an arthropod-borne bunyavirus, recently has emerged as a significant veterinary pathogen causing infertility and congenital malformations in North American ruminants. To investigate the role of vector feeding on CV infection, adult mice were injected subcutaneously with CV, CV and vector thorax extract (a source of vector saliva), or CV into the site of intense, noninfected-mosquito feeding. Mice did not become infected after injection of CV or CV and vector saliva, nor did they produce antibodies to CV. However, injection of CV into sites of mosquito feeding resulted in viremia and production of anti-CV antibody by 2 wk after infection. This enhancement of CV infection resulted after feeding by Aedes triseriatus (Say), Ae. aegypti (L.), or Culex pipiens (L.). Enhancement occurred when injection was delayed up to 4 h after mosquito feeding, but it was not observed when virus injection was performed at a site distant from mosquito feeding. These results indicate that arbovirus infection may be enhanced by mosquito-vertebrate host interactions and that replication of arboviruses in arthropod vectors may not be responsible for increased virulence of infections mediated by infected arthropods. Enhanced CV infection in pregnant mice did not result in infertility or malformed pups, indicating that the mouse is not a suitable model to study CV-induced malformations</description><subject>Aedes</subject><subject>AEDES AEGYPTI</subject><subject>AEDES TRISERIATUS</subject><subject>Animals</subject><subject>Arthropod Vectors</subject><subject>Biological and medical sciences</subject><subject>Bunyamwera virus</subject><subject>BUNYAVIRIDAE</subject><subject>Bunyaviridae Infections - transmission</subject><subject>Bunyaviridae Infections - virology</subject><subject>COMPORTEMENT ALIMENTAIRE</subject><subject>Culex</subject><subject>CULEX PIPIENS</subject><subject>Culicidae</subject><subject>DISEASE MODELS</subject><subject>Disease Models, Animal</subject><subject>DISEASE VECTORS</subject><subject>Eating</subject><subject>FEEDING HABITS</subject><subject>Fertility</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GESTACION</subject><subject>GESTATION</subject><subject>HABITOS ALIMENTARIOS</subject><subject>HEMATOPHAGY</subject><subject>INFECCION</subject><subject>INFECTION</subject><subject>Insect Bites and Stings</subject><subject>Medically important nuisances and vectors, pests of stored products and materials: population survey and control</subject><subject>MICE</subject><subject>MODELE</subject><subject>MODELOS</subject><subject>PATHOGENESE</subject><subject>PATHOGENESIS</subject><subject>PATOGENESIS</subject><subject>PREGNANCY</subject><subject>RATON</subject><subject>SOURIS</subject><subject>VECTEUR DE MALADIE</subject><subject>VECTOR ENHANCE INFECTION</subject><subject>VECTORES</subject><subject>VECTORS</subject><subject>Vectors. Intermediate hosts</subject><subject>Viremia - transmission</subject><subject>Viremia - virology</subject><issn>0022-2585</issn><issn>1938-2928</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkM1LHDEYxkOp6Nb23ouQQxF7mN18z-Soi62C4qHdXnoImeSNRmYyOpkR9r9vioN4eh94Pnj5IfSVkjUlmm8ee_CQpg2Xa75min5AK6p5UzHNmo9oRQhjFZONPEKfcn4khDRU6EN0qBWVUogV-ns75Oc5TgMOAD6m-yomPzvwGNKDTQ76Mo-HgLfWPQD-Y7sO9vgljnPGZxdz2tuio7fwHccUwE1xSEXhPjr4jA6C7TJ8We4x2v24_L29qm7ufl5vz28qJxoxVY2WoXW-5ZxIWTtdW6q8VM6zUJ5tuWKSSidAMu3bIGqprBKtcIrwFgQL_Bidvu4-jcPzDHkyfcwOus4mGOZsqBJcFSwlSF6DbhxyHiGYpzH2dtwbSsx_nmbhabg03BSepXKybM9t8d4KC8Dif1t8m53twliYxfwWY5wqKd_NBDsYez-WyO4X1bommtFa8X9tG4hm</recordid><startdate>19980501</startdate><enddate>19980501</enddate><creator>Edwards, J.F. (Texas AandM University, College Station, TX.)</creator><creator>Higgs, S</creator><creator>Beaty, B.J</creator><general>Entomological Society of America</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>19980501</creationdate><title>Mosquito feeding-induced enhancement of Cache Valley virus (Bunyaviridae) infection in mice</title><author>Edwards, J.F. (Texas AandM University, College Station, TX.) ; Higgs, S ; Beaty, B.J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-895fbcdb330557c97a16d56cd2f149b362515c4e529dbf4756a64b4c603be42f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Aedes</topic><topic>AEDES AEGYPTI</topic><topic>AEDES TRISERIATUS</topic><topic>Animals</topic><topic>Arthropod Vectors</topic><topic>Biological and medical sciences</topic><topic>Bunyamwera virus</topic><topic>BUNYAVIRIDAE</topic><topic>Bunyaviridae Infections - transmission</topic><topic>Bunyaviridae Infections - virology</topic><topic>COMPORTEMENT ALIMENTAIRE</topic><topic>Culex</topic><topic>CULEX PIPIENS</topic><topic>Culicidae</topic><topic>DISEASE MODELS</topic><topic>Disease Models, Animal</topic><topic>DISEASE VECTORS</topic><topic>Eating</topic><topic>FEEDING HABITS</topic><topic>Fertility</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GESTACION</topic><topic>GESTATION</topic><topic>HABITOS ALIMENTARIOS</topic><topic>HEMATOPHAGY</topic><topic>INFECCION</topic><topic>INFECTION</topic><topic>Insect Bites and Stings</topic><topic>Medically important nuisances and vectors, pests of stored products and materials: population survey and control</topic><topic>MICE</topic><topic>MODELE</topic><topic>MODELOS</topic><topic>PATHOGENESE</topic><topic>PATHOGENESIS</topic><topic>PATOGENESIS</topic><topic>PREGNANCY</topic><topic>RATON</topic><topic>SOURIS</topic><topic>VECTEUR DE MALADIE</topic><topic>VECTOR ENHANCE INFECTION</topic><topic>VECTORES</topic><topic>VECTORS</topic><topic>Vectors. Intermediate hosts</topic><topic>Viremia - transmission</topic><topic>Viremia - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Edwards, J.F. (Texas AandM University, College Station, TX.)</creatorcontrib><creatorcontrib>Higgs, S</creatorcontrib><creatorcontrib>Beaty, B.J</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of medical entomology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Edwards, J.F. (Texas AandM University, College Station, TX.)</au><au>Higgs, S</au><au>Beaty, B.J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mosquito feeding-induced enhancement of Cache Valley virus (Bunyaviridae) infection in mice</atitle><jtitle>Journal of medical entomology</jtitle><addtitle>J Med Entomol</addtitle><date>1998-05-01</date><risdate>1998</risdate><volume>35</volume><issue>3</issue><spage>261</spage><epage>265</epage><pages>261-265</pages><issn>0022-2585</issn><eissn>1938-2928</eissn><coden>JMENA6</coden><abstract>Cache Valley (CV) virus, an arthropod-borne bunyavirus, recently has emerged as a significant veterinary pathogen causing infertility and congenital malformations in North American ruminants. To investigate the role of vector feeding on CV infection, adult mice were injected subcutaneously with CV, CV and vector thorax extract (a source of vector saliva), or CV into the site of intense, noninfected-mosquito feeding. Mice did not become infected after injection of CV or CV and vector saliva, nor did they produce antibodies to CV. However, injection of CV into sites of mosquito feeding resulted in viremia and production of anti-CV antibody by 2 wk after infection. This enhancement of CV infection resulted after feeding by Aedes triseriatus (Say), Ae. aegypti (L.), or Culex pipiens (L.). Enhancement occurred when injection was delayed up to 4 h after mosquito feeding, but it was not observed when virus injection was performed at a site distant from mosquito feeding. These results indicate that arbovirus infection may be enhanced by mosquito-vertebrate host interactions and that replication of arboviruses in arthropod vectors may not be responsible for increased virulence of infections mediated by infected arthropods. Enhanced CV infection in pregnant mice did not result in infertility or malformed pups, indicating that the mouse is not a suitable model to study CV-induced malformations</abstract><cop>Lanham, MD</cop><pub>Entomological Society of America</pub><pmid>9615544</pmid><doi>10.1093/jmedent/35.3.261</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0022-2585 |
| ispartof | Journal of medical entomology, 1998-05, Vol.35 (3), p.261-265 |
| issn | 0022-2585 1938-2928 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Aedes AEDES AEGYPTI AEDES TRISERIATUS Animals Arthropod Vectors Biological and medical sciences Bunyamwera virus BUNYAVIRIDAE Bunyaviridae Infections - transmission Bunyaviridae Infections - virology COMPORTEMENT ALIMENTAIRE Culex CULEX PIPIENS Culicidae DISEASE MODELS Disease Models, Animal DISEASE VECTORS Eating FEEDING HABITS Fertility Fundamental and applied biological sciences. Psychology GESTACION GESTATION HABITOS ALIMENTARIOS HEMATOPHAGY INFECCION INFECTION Insect Bites and Stings Medically important nuisances and vectors, pests of stored products and materials: population survey and control MICE MODELE MODELOS PATHOGENESE PATHOGENESIS PATOGENESIS PREGNANCY RATON SOURIS VECTEUR DE MALADIE VECTOR ENHANCE INFECTION VECTORES VECTORS Vectors. Intermediate hosts Viremia - transmission Viremia - virology |
| title | Mosquito feeding-induced enhancement of Cache Valley virus (Bunyaviridae) infection in mice |
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