B7-H4 downregulation induces mitochondrial dysfunction and enhances doxorubicin sensitivity via the cAMP/CREB/PGC1-α signaling pathway in HeLa cells

B7-H4 is a B7 family coregulatory protein that inhibits T cell-mediated immunity. B7-H4 is overexpressed in various cancers; however, the functional role of B7-H4 in cancer metabolism is poorly understood. Because mitochondria play pivotal roles in development, proliferation, and death of cancer cel...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pflügers Archiv 2014-12, Vol.466 (12), p.2323-2338
Hauptverfasser:	Kim, Hyoung Kyu, Song, In-Sung, Lee, Sun Young, Jeong, Seung Hun, Lee, Sung Ryul, Heo, Hye Jin, Thu, Vu Thi, Kim, Nari, Ko, Kyung Soo, Rhee, Byoung Doo, Jeong, Dae Hun, Kim, Young Nam, Han, Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Aged Antibiotics, Antineoplastic - pharmacology Apoptosis Biomedical and Life Sciences Biomedicine Cell Biology Cyclic AMP - metabolism Cyclic AMP Response Element-Binding Protein - metabolism Down-Regulation Doxorubicin - pharmacology Female HeLa Cells Human Physiology Humans Middle Aged Mitochondria - drug effects Mitochondria - metabolism Molecular Medicine Neurosciences Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Receptors Signal Transduction Signaling and Cell Physiology Transcription Factors - metabolism Uterine Cervical Neoplasms - metabolism V-Set Domain-Containing T-Cell Activation Inhibitor 1 - genetics V-Set Domain-Containing T-Cell Activation Inhibitor 1 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!