Succinate dehydrogenase-deficient renal cell carcinoma: detailed characterization of 11 tumors defining a unique subtype of renal cell carcinoma

Patients with germline mutation of succinate dehydrogenase (SDH) subunit genes are prone to develop paraganglioma, gastrointestinal stromal tumor, and rarely renal cell carcinoma (RCC). However, SDH-deficient RCC is not yet widely recognized. We identified such tumors by distinctive morphology and c...

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Veröffentlicht in:	Modern pathology 2015-01, Vol.28 (1), p.80-94
Hauptverfasser:	Williamson, Sean R, Eble, John N, Amin, Mahul B, Gupta, Nilesh S, Smith, Steven C, Sholl, Lynette M, Montironi, Rodolfo, Hirsch, Michelle S, Hornick, Jason L
Format:	Artikel
Sprache:	eng
Schlagworte:	692/420/2489/144 692/699/2768/1588/1351 692/700/139/422 Adult Aged Carcinoma, Renal Cell - enzymology Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - pathology Female High-Throughput Nucleotide Sequencing Humans Immunohistochemistry Kidney Neoplasms - enzymology Kidney Neoplasms - genetics Kidney Neoplasms - pathology Laboratory Medicine Male Medicine Medicine & Public Health Middle Aged original-article Pathology Succinate Dehydrogenase - deficiency Succinate Dehydrogenase - genetics Young Adult
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