Leptin and Adiponectin mRNA Expression From the Adipose Tissue Surrounding the Adrenal Neoplasia
Context: Interplay between adipose tissue and adrenal glands has been recently suggested, without well-founded actions of locally adipose tissue surrounding the adrenal glands. Objective: We hypothesized that the local expression of leptin and adiponectin can be associated with pathological changes...
Gespeichert in:
| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2015-01, Vol.100 (1), p.E101-E104 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | E104 |
|---|---|
| container_issue | 1 |
| container_start_page | E101 |
| container_title | The journal of clinical endocrinology and metabolism |
| container_volume | 100 |
| creator | Letizia, Claudio Petramala, Luigi Di Gioia, Cira Rosaria Tiziana Chiappetta, Caterina Zinnamosca, Laura Marinelli, Cristiano Iannucci, Gino Ciardi, Antonio De Toma, Giorgio Iacobellis, Gianluca |
| description | Context:
Interplay between adipose tissue and adrenal glands has been recently suggested, without well-founded actions of locally adipose tissue surrounding the adrenal glands.
Objective:
We hypothesized that the local expression of leptin and adiponectin can be associated with pathological changes of the adrenal glands.
Patients and Main Outcome Measures:
We evaluated RT-PCR of leptin and adiponectin mRNA expression from the adipose tissue surrounding adrenal glands in 30 patients, collecting adipose tissue surrounding the adrenal neoplasms, peri-renal and subcutaneous depots.
Results:
Leptin mRNA levels from adrenal neoplasia and peri-renal fat were significantly higher in aldosterone-producing adenoma than in nonfunctioning adenomas (P < 0.001 and P < 0.02, respectively). In patients with Cushing's syndrome leptin mRNA levels were significantly higher in adrenal fat than in peri-renal (P < 0.05) and subcutaneous adipose tissue (P < 0.001). Adiponectin mRNA expression from adrenal neoplasia was significantly lower than that from peri-renal and subcutaneous fat depots (P < 0.05). Leptin and adiponectin plasma levels significantly correlated with their mRNA expression from the fat depot surrounding the adrenal neoplasia.
Conclusions:
Our findings suggest an active role of the fat depot surrounding the adrenal neoplasia, with local secretion of leptin and adiponectin. |
| doi_str_mv | 10.1210/jc.2014-2274 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1643147026</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1643147026</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5541-4f999006b154b79de7ccf8da822951d162b4d1cc3c3892e36adab50b8f01bf073</originalsourceid><addsrcrecordid>eNptkE1v1DAQhi0EotvCjTPKkUPTevyRxMdV1VKkVStBkbgZx56wWRI72Ina_nsSsnDC0sgazTOvRg8h74BeAAN6ebAXjILIGSvFC7IBJWRegipfkg2lDHJVsm8n5DSlA50xIflrcsIkB64ANuT7Doex9ZnxLtu6dgge7dL3n--22fXTEDGlNvjsJoY-G_e4QgmzhzalCbMvU4xh8q71P47jiN502R2GoTOpNW_Iq8Z0Cd8e_zPy9eb64eo2391__HS13eVWSgG5aJRSlBY1SFGXymFpbVM5UzGmJDgoWC0cWMstrxRDXhhnaknrqqFQN7TkZ-TDmjvE8GvCNOq-TRa7zngMU9JQCA6ipKyY0fMVtTGkFLHRQ2x7E581UL041QerF6d6cTrj74_JU92j-wf_lTgDYgUeQzdiTD-76RGj3qPpxr2m8xNFWeVzoqQwd_lcxbLG1zX0LtjYevxjWx_CFGeF6f_X_AbKIZJI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1643147026</pqid></control><display><type>article</type><title>Leptin and Adiponectin mRNA Expression From the Adipose Tissue Surrounding the Adrenal Neoplasia</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Letizia, Claudio ; Petramala, Luigi ; Di Gioia, Cira Rosaria Tiziana ; Chiappetta, Caterina ; Zinnamosca, Laura ; Marinelli, Cristiano ; Iannucci, Gino ; Ciardi, Antonio ; De Toma, Giorgio ; Iacobellis, Gianluca</creator><creatorcontrib>Letizia, Claudio ; Petramala, Luigi ; Di Gioia, Cira Rosaria Tiziana ; Chiappetta, Caterina ; Zinnamosca, Laura ; Marinelli, Cristiano ; Iannucci, Gino ; Ciardi, Antonio ; De Toma, Giorgio ; Iacobellis, Gianluca</creatorcontrib><description>Context:
Interplay between adipose tissue and adrenal glands has been recently suggested, without well-founded actions of locally adipose tissue surrounding the adrenal glands.
Objective:
We hypothesized that the local expression of leptin and adiponectin can be associated with pathological changes of the adrenal glands.
Patients and Main Outcome Measures:
We evaluated RT-PCR of leptin and adiponectin mRNA expression from the adipose tissue surrounding adrenal glands in 30 patients, collecting adipose tissue surrounding the adrenal neoplasms, peri-renal and subcutaneous depots.
Results:
Leptin mRNA levels from adrenal neoplasia and peri-renal fat were significantly higher in aldosterone-producing adenoma than in nonfunctioning adenomas (P < 0.001 and P < 0.02, respectively). In patients with Cushing's syndrome leptin mRNA levels were significantly higher in adrenal fat than in peri-renal (P < 0.05) and subcutaneous adipose tissue (P < 0.001). Adiponectin mRNA expression from adrenal neoplasia was significantly lower than that from peri-renal and subcutaneous fat depots (P < 0.05). Leptin and adiponectin plasma levels significantly correlated with their mRNA expression from the fat depot surrounding the adrenal neoplasia.
Conclusions:
Our findings suggest an active role of the fat depot surrounding the adrenal neoplasia, with local secretion of leptin and adiponectin.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2014-2274</identifier><identifier>PMID: 25313911</identifier><language>eng</language><publisher>United States: Endocrine Society</publisher><subject>Adenoma - genetics ; Adenoma - metabolism ; Adenoma - pathology ; Adiponectin - genetics ; Adiponectin - metabolism ; Adipose Tissue - metabolism ; Adipose Tissue - pathology ; Adrenal Gland Neoplasms - genetics ; Adrenal Gland Neoplasms - metabolism ; Adrenal Gland Neoplasms - pathology ; Adult ; Aged ; Female ; Humans ; Leptin - genetics ; Leptin - metabolism ; Male ; Middle Aged ; RNA, Messenger - genetics ; RNA, Messenger - metabolism</subject><ispartof>The journal of clinical endocrinology and metabolism, 2015-01, Vol.100 (1), p.E101-E104</ispartof><rights>Copyright © 2015 by the Endocrine Society</rights><rights>Copyright © 2015 by The Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5541-4f999006b154b79de7ccf8da822951d162b4d1cc3c3892e36adab50b8f01bf073</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25313911$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Letizia, Claudio</creatorcontrib><creatorcontrib>Petramala, Luigi</creatorcontrib><creatorcontrib>Di Gioia, Cira Rosaria Tiziana</creatorcontrib><creatorcontrib>Chiappetta, Caterina</creatorcontrib><creatorcontrib>Zinnamosca, Laura</creatorcontrib><creatorcontrib>Marinelli, Cristiano</creatorcontrib><creatorcontrib>Iannucci, Gino</creatorcontrib><creatorcontrib>Ciardi, Antonio</creatorcontrib><creatorcontrib>De Toma, Giorgio</creatorcontrib><creatorcontrib>Iacobellis, Gianluca</creatorcontrib><title>Leptin and Adiponectin mRNA Expression From the Adipose Tissue Surrounding the Adrenal Neoplasia</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Context:
Interplay between adipose tissue and adrenal glands has been recently suggested, without well-founded actions of locally adipose tissue surrounding the adrenal glands.
Objective:
We hypothesized that the local expression of leptin and adiponectin can be associated with pathological changes of the adrenal glands.
Patients and Main Outcome Measures:
We evaluated RT-PCR of leptin and adiponectin mRNA expression from the adipose tissue surrounding adrenal glands in 30 patients, collecting adipose tissue surrounding the adrenal neoplasms, peri-renal and subcutaneous depots.
Results:
Leptin mRNA levels from adrenal neoplasia and peri-renal fat were significantly higher in aldosterone-producing adenoma than in nonfunctioning adenomas (P < 0.001 and P < 0.02, respectively). In patients with Cushing's syndrome leptin mRNA levels were significantly higher in adrenal fat than in peri-renal (P < 0.05) and subcutaneous adipose tissue (P < 0.001). Adiponectin mRNA expression from adrenal neoplasia was significantly lower than that from peri-renal and subcutaneous fat depots (P < 0.05). Leptin and adiponectin plasma levels significantly correlated with their mRNA expression from the fat depot surrounding the adrenal neoplasia.
Conclusions:
Our findings suggest an active role of the fat depot surrounding the adrenal neoplasia, with local secretion of leptin and adiponectin.</description><subject>Adenoma - genetics</subject><subject>Adenoma - metabolism</subject><subject>Adenoma - pathology</subject><subject>Adiponectin - genetics</subject><subject>Adiponectin - metabolism</subject><subject>Adipose Tissue - metabolism</subject><subject>Adipose Tissue - pathology</subject><subject>Adrenal Gland Neoplasms - genetics</subject><subject>Adrenal Gland Neoplasms - metabolism</subject><subject>Adrenal Gland Neoplasms - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Female</subject><subject>Humans</subject><subject>Leptin - genetics</subject><subject>Leptin - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1v1DAQhi0EotvCjTPKkUPTevyRxMdV1VKkVStBkbgZx56wWRI72Ina_nsSsnDC0sgazTOvRg8h74BeAAN6ebAXjILIGSvFC7IBJWRegipfkg2lDHJVsm8n5DSlA50xIflrcsIkB64ANuT7Doex9ZnxLtu6dgge7dL3n--22fXTEDGlNvjsJoY-G_e4QgmzhzalCbMvU4xh8q71P47jiN502R2GoTOpNW_Iq8Z0Cd8e_zPy9eb64eo2391__HS13eVWSgG5aJRSlBY1SFGXymFpbVM5UzGmJDgoWC0cWMstrxRDXhhnaknrqqFQN7TkZ-TDmjvE8GvCNOq-TRa7zngMU9JQCA6ipKyY0fMVtTGkFLHRQ2x7E581UL041QerF6d6cTrj74_JU92j-wf_lTgDYgUeQzdiTD-76RGj3qPpxr2m8xNFWeVzoqQwd_lcxbLG1zX0LtjYevxjWx_CFGeF6f_X_AbKIZJI</recordid><startdate>201501</startdate><enddate>201501</enddate><creator>Letizia, Claudio</creator><creator>Petramala, Luigi</creator><creator>Di Gioia, Cira Rosaria Tiziana</creator><creator>Chiappetta, Caterina</creator><creator>Zinnamosca, Laura</creator><creator>Marinelli, Cristiano</creator><creator>Iannucci, Gino</creator><creator>Ciardi, Antonio</creator><creator>De Toma, Giorgio</creator><creator>Iacobellis, Gianluca</creator><general>Endocrine Society</general><general>Copyright by The Endocrine Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201501</creationdate><title>Leptin and Adiponectin mRNA Expression From the Adipose Tissue Surrounding the Adrenal Neoplasia</title><author>Letizia, Claudio ; Petramala, Luigi ; Di Gioia, Cira Rosaria Tiziana ; Chiappetta, Caterina ; Zinnamosca, Laura ; Marinelli, Cristiano ; Iannucci, Gino ; Ciardi, Antonio ; De Toma, Giorgio ; Iacobellis, Gianluca</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5541-4f999006b154b79de7ccf8da822951d162b4d1cc3c3892e36adab50b8f01bf073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adenoma - genetics</topic><topic>Adenoma - metabolism</topic><topic>Adenoma - pathology</topic><topic>Adiponectin - genetics</topic><topic>Adiponectin - metabolism</topic><topic>Adipose Tissue - metabolism</topic><topic>Adipose Tissue - pathology</topic><topic>Adrenal Gland Neoplasms - genetics</topic><topic>Adrenal Gland Neoplasms - metabolism</topic><topic>Adrenal Gland Neoplasms - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Female</topic><topic>Humans</topic><topic>Leptin - genetics</topic><topic>Leptin - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Letizia, Claudio</creatorcontrib><creatorcontrib>Petramala, Luigi</creatorcontrib><creatorcontrib>Di Gioia, Cira Rosaria Tiziana</creatorcontrib><creatorcontrib>Chiappetta, Caterina</creatorcontrib><creatorcontrib>Zinnamosca, Laura</creatorcontrib><creatorcontrib>Marinelli, Cristiano</creatorcontrib><creatorcontrib>Iannucci, Gino</creatorcontrib><creatorcontrib>Ciardi, Antonio</creatorcontrib><creatorcontrib>De Toma, Giorgio</creatorcontrib><creatorcontrib>Iacobellis, Gianluca</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Letizia, Claudio</au><au>Petramala, Luigi</au><au>Di Gioia, Cira Rosaria Tiziana</au><au>Chiappetta, Caterina</au><au>Zinnamosca, Laura</au><au>Marinelli, Cristiano</au><au>Iannucci, Gino</au><au>Ciardi, Antonio</au><au>De Toma, Giorgio</au><au>Iacobellis, Gianluca</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leptin and Adiponectin mRNA Expression From the Adipose Tissue Surrounding the Adrenal Neoplasia</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2015-01</date><risdate>2015</risdate><volume>100</volume><issue>1</issue><spage>E101</spage><epage>E104</epage><pages>E101-E104</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><abstract>Context:
Interplay between adipose tissue and adrenal glands has been recently suggested, without well-founded actions of locally adipose tissue surrounding the adrenal glands.
Objective:
We hypothesized that the local expression of leptin and adiponectin can be associated with pathological changes of the adrenal glands.
Patients and Main Outcome Measures:
We evaluated RT-PCR of leptin and adiponectin mRNA expression from the adipose tissue surrounding adrenal glands in 30 patients, collecting adipose tissue surrounding the adrenal neoplasms, peri-renal and subcutaneous depots.
Results:
Leptin mRNA levels from adrenal neoplasia and peri-renal fat were significantly higher in aldosterone-producing adenoma than in nonfunctioning adenomas (P < 0.001 and P < 0.02, respectively). In patients with Cushing's syndrome leptin mRNA levels were significantly higher in adrenal fat than in peri-renal (P < 0.05) and subcutaneous adipose tissue (P < 0.001). Adiponectin mRNA expression from adrenal neoplasia was significantly lower than that from peri-renal and subcutaneous fat depots (P < 0.05). Leptin and adiponectin plasma levels significantly correlated with their mRNA expression from the fat depot surrounding the adrenal neoplasia.
Conclusions:
Our findings suggest an active role of the fat depot surrounding the adrenal neoplasia, with local secretion of leptin and adiponectin.</abstract><cop>United States</cop><pub>Endocrine Society</pub><pmid>25313911</pmid><doi>10.1210/jc.2014-2274</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-972X |
| ispartof | The journal of clinical endocrinology and metabolism, 2015-01, Vol.100 (1), p.E101-E104 |
| issn | 0021-972X 1945-7197 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1643147026 |
| source | MEDLINE; Journals@Ovid Complete; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adenoma - genetics Adenoma - metabolism Adenoma - pathology Adiponectin - genetics Adiponectin - metabolism Adipose Tissue - metabolism Adipose Tissue - pathology Adrenal Gland Neoplasms - genetics Adrenal Gland Neoplasms - metabolism Adrenal Gland Neoplasms - pathology Adult Aged Female Humans Leptin - genetics Leptin - metabolism Male Middle Aged RNA, Messenger - genetics RNA, Messenger - metabolism |
| title | Leptin and Adiponectin mRNA Expression From the Adipose Tissue Surrounding the Adrenal Neoplasia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T08%3A29%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Leptin%20and%20Adiponectin%20mRNA%20Expression%20From%20the%20Adipose%20Tissue%20Surrounding%20the%20Adrenal%20Neoplasia&rft.jtitle=The%20journal%20of%20clinical%20endocrinology%20and%20metabolism&rft.au=Letizia,%20Claudio&rft.date=2015-01&rft.volume=100&rft.issue=1&rft.spage=E101&rft.epage=E104&rft.pages=E101-E104&rft.issn=0021-972X&rft.eissn=1945-7197&rft_id=info:doi/10.1210/jc.2014-2274&rft_dat=%3Cproquest_cross%3E1643147026%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1643147026&rft_id=info:pmid/25313911&rfr_iscdi=true |