Redox gene therapy protects human IB-3 lung epithelial cells against ionizing radiation-induced apoptosis

Toxicity to nontumor-derived tissue has proven to be a significant obstacle in achieving therapeutic levels of gamma irradiation in the treatment of cancer. The formation of reactive oxygen species (ROS) such as superoxide radicals (O2-) following irradiation is thought to be a major determinant of...

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Veröffentlicht in:	Human gene therapy 1998-06, Vol.9 (9), p.1381-1386
Hauptverfasser:	Zwacka, R M, Dudus, L, Epperly, M W, Greenberger, J S, Engelhardt, J F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Apoptosis Blotting, Western Cell Line Epithelial Cells - radiation effects Fluorescent Antibody Technique Genetic Therapy Genetic Vectors Humans Lung - cytology Radiation, Ionizing Radiation-Protective Agents Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Transgenes
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