Directed Mutagenesis of a Sindbis Virus Pathogenesis Site

The E2 glycoprotein gene of Sindbis virus contains three neutralizing antigenic sites, and examination of monoclonal antibody (MAb) escape mutants of one of these, the E2c site, has suggested an association of the E2c domain with determinants of virulence in neonatal mice. Codons associated with the...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 1993-03, Vol.193 (1), p.149-159
Hauptverfasser:	Schoepp, Randal J., Johnston, Robert E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal arbovirus Base Sequence Biological and medical sciences Brain - cytology Brain - metabolism Fundamental and applied biological sciences. Psychology Mice Microbiology Molecular Sequence Data Morphology, structure, chemical composition, physicochemical properties Mutagenesis, Site-Directed - genetics Protein Binding Sindbis Virus - genetics Sindbis Virus - pathogenicity Viral Envelope Proteins - genetics Viral Envelope Proteins - metabolism Virion - genetics Virology Virulence - genetics
Online-Zugang:	Volltext
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