Effects of codeine, naproxen and dexamethasone on formalin-induced pain in the naked mole-rat
A DILUTE solution of formalin (20 μ1 of 10% formalin) was injected subcutaneously in the dorsal right hind paw of the naked mole-rat. The injection of the dilute formalin produced two periods of pain behaviour, the early (0–5 minutes) and the late phase (25–60 minutes). These were quantified as the...
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| Veröffentlicht in: | Neuroreport 1993-01, Vol.4 (1), p.25-28 |
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| creator | Karim, Farzana Kanui, Titus Ikusya Mbugua, Susan |
| description | A DILUTE solution of formalin (20 μ1 of 10% formalin) was injected subcutaneously in the dorsal right hind paw of the naked mole-rat. The injection of the dilute formalin produced two periods of pain behaviour, the early (0–5 minutes) and the late phase (25–60 minutes). These were quantified as the total time spent licking the injected paw. Codeine phosphate (10, 25 or 50 mg kg) significantly reduced pain behaviour in both the early and late phase. Codeine administration also induced aggressive, hyperactive behaviour and motor impairment that was nalox-one (2 mg kg) reversible. Naproxen (200 mg kg) and dexamethasone phosphate (30 mg kg) significantly reduced licking activity in the late phase only. |
| doi_str_mv | 10.1097/00001756-199301000-00006 |
| format | Article |
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The injection of the dilute formalin produced two periods of pain behaviour, the early (0–5 minutes) and the late phase (25–60 minutes). These were quantified as the total time spent licking the injected paw. Codeine phosphate (10, 25 or 50 mg kg) significantly reduced pain behaviour in both the early and late phase. Codeine administration also induced aggressive, hyperactive behaviour and motor impairment that was nalox-one (2 mg kg) reversible. Naproxen (200 mg kg) and dexamethasone phosphate (30 mg kg) significantly reduced licking activity in the late phase only.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-199301000-00006</identifier><identifier>PMID: 8453032</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Animals ; Behavior, Animal - drug effects ; Behavioral psychophysiology ; Biological and medical sciences ; Codeine - pharmacology ; Dexamethasone - pharmacology ; Dose-Response Relationship, Drug ; Formaldehyde ; Fundamental and applied biological sciences. Psychology ; Heterocephalus glaber ; Injections, Intraperitoneal ; Injections, Subcutaneous ; Miscellaneous ; Muscle Rigidity - chemically induced ; Naloxone - pharmacology ; Naproxen - pharmacology ; Pain - chemically induced ; Pain - prevention & control ; Psychology. Psychoanalysis. Psychiatry ; Psychology. 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The injection of the dilute formalin produced two periods of pain behaviour, the early (0–5 minutes) and the late phase (25–60 minutes). These were quantified as the total time spent licking the injected paw. Codeine phosphate (10, 25 or 50 mg kg) significantly reduced pain behaviour in both the early and late phase. Codeine administration also induced aggressive, hyperactive behaviour and motor impairment that was nalox-one (2 mg kg) reversible. Naproxen (200 mg kg) and dexamethasone phosphate (30 mg kg) significantly reduced licking activity in the late phase only.</description><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Codeine - pharmacology</subject><subject>Dexamethasone - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Formaldehyde</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heterocephalus glaber</subject><subject>Injections, Intraperitoneal</subject><subject>Injections, Subcutaneous</subject><subject>Miscellaneous</subject><subject>Muscle Rigidity - chemically induced</subject><subject>Naloxone - pharmacology</subject><subject>Naproxen - pharmacology</subject><subject>Pain - chemically induced</subject><subject>Pain - prevention & control</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rodentia - physiology</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUGPFCEQhYnRrLOrP8GEg_FkKzTQNEezWV2TTbxo4sWQGigy7dIwQnd2_fcyzjg3CQnh1feAehBCOXvHmdHvWRtcq6HjxgjG2647SMMTsuFSi06p8ftTsmFGmU6aQT0nl7X-bIRhfLwgF6NUgol-Q37chIBuqTQH6rLHKeFbmmBf8iMmCslTj48w47KDmhPSnGjIZYY4pW5KfnXo6R6mRNtcdtis902Zc8SuwPKCPAsQK748rVfk28ebr9e33d2XT5-vP9x1TvLWBPTCb4UAL5lkXgXPlRaa68EIgejQaTYKJfShRSaQCVBbA4PjqtcQGIgr8uZ4bnv3rxXrYuepOowREua1Wj7IfmRKNnA8gq7kWgsGuy_TDOW35cwekrX_krXnZP9KQ7O-Ot2xbmf0Z-MpylZ_fapDdRBDgeSmesbkIHjPx4bJI_aQ44Kl3sf1AYvdIcRlZ__3r-IP6mOPAg</recordid><startdate>199301</startdate><enddate>199301</enddate><creator>Karim, Farzana</creator><creator>Kanui, Titus Ikusya</creator><creator>Mbugua, Susan</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>199301</creationdate><title>Effects of codeine, naproxen and dexamethasone on formalin-induced pain in the naked mole-rat</title><author>Karim, Farzana ; Kanui, Titus Ikusya ; Mbugua, Susan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4156-a23db33ad4040d5fd15737176933eecec7083537000003e03a5b9a6c1527af0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Codeine - pharmacology</topic><topic>Dexamethasone - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Formaldehyde</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heterocephalus glaber</topic><topic>Injections, Intraperitoneal</topic><topic>Injections, Subcutaneous</topic><topic>Miscellaneous</topic><topic>Muscle Rigidity - chemically induced</topic><topic>Naloxone - pharmacology</topic><topic>Naproxen - pharmacology</topic><topic>Pain - chemically induced</topic><topic>Pain - prevention & control</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rodentia - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karim, Farzana</creatorcontrib><creatorcontrib>Kanui, Titus Ikusya</creatorcontrib><creatorcontrib>Mbugua, Susan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karim, Farzana</au><au>Kanui, Titus Ikusya</au><au>Mbugua, Susan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of codeine, naproxen and dexamethasone on formalin-induced pain in the naked mole-rat</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1993-01</date><risdate>1993</risdate><volume>4</volume><issue>1</issue><spage>25</spage><epage>28</epage><pages>25-28</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>A DILUTE solution of formalin (20 μ1 of 10% formalin) was injected subcutaneously in the dorsal right hind paw of the naked mole-rat. The injection of the dilute formalin produced two periods of pain behaviour, the early (0–5 minutes) and the late phase (25–60 minutes). These were quantified as the total time spent licking the injected paw. Codeine phosphate (10, 25 or 50 mg kg) significantly reduced pain behaviour in both the early and late phase. Codeine administration also induced aggressive, hyperactive behaviour and motor impairment that was nalox-one (2 mg kg) reversible. Naproxen (200 mg kg) and dexamethasone phosphate (30 mg kg) significantly reduced licking activity in the late phase only.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>8453032</pmid><doi>10.1097/00001756-199301000-00006</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Behavior, Animal - drug effects Behavioral psychophysiology Biological and medical sciences Codeine - pharmacology Dexamethasone - pharmacology Dose-Response Relationship, Drug Formaldehyde Fundamental and applied biological sciences. Psychology Heterocephalus glaber Injections, Intraperitoneal Injections, Subcutaneous Miscellaneous Muscle Rigidity - chemically induced Naloxone - pharmacology Naproxen - pharmacology Pain - chemically induced Pain - prevention & control Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rodentia - physiology |
| title | Effects of codeine, naproxen and dexamethasone on formalin-induced pain in the naked mole-rat |
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