The Effect of Deletion of the V3 Loop of gp120 on Cytotoxic T Cell Responses and HIV gp120-Mediated Pathogenesis

New strategies for improving the efficacy of HIV vaccines are of significant importance. In this study, we analyzed the effect of deletion of the hypervariable V3 loop of gp120 on envelope (env)-specific CTL responses in PBMC of HIV-infected individuals. We showed increased CTL activities against co...

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Veröffentlicht in:	The Journal of immunology (1950) 1998-06, Vol.160 (11), p.5676-5683
Hauptverfasser:	Kmieciak, Dariusz, Wasik, Thomas J, Teppler, Hedy, Pientka, Janet, Hsu, Susan H, Takahashi, Hidemi, Okumura, Ko, Kaneko, Yutaro, Kozbor, Danuta
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibody-Dependent Cell Cytotoxicity - genetics Apoptosis - genetics Apoptosis - immunology Cell Line, Transformed Gene Products, env - biosynthesis Gene Products, env - genetics Giant Cells - immunology Giant Cells - virology HIV Envelope Protein gp120 - genetics HIV Envelope Protein gp120 - physiology HIV Infections - etiology HIV Infections - immunology Humans Leukocytes, Mononuclear - immunology Mutagenesis, Site-Directed Sequence Deletion T-Lymphocytes, Cytotoxic - immunology Vaccinia virus - genetics
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