Immunologic findings among lead-exposed workers
A comprehensive panel of immune parameters was evaluated among 145 lead‐exposed workers with a median blood lead level (BLL) of 39 μg/dL (range: 15–55 μg/dL) and 84 unexposed workers. After adjusting for covariates, we found no major differences in the percentage of CD3+ cells, CD4+ T cells, CD8+ T...
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| Veröffentlicht in: | American journal of industrial medicine 1998-04, Vol.33 (4), p.400-408 |
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| creator | Pinkerton, Lynne E. Biagini, Raymond E. Ward, Elizabeth M. Hull, R. DeLon Deddens, James A. Boeniger, Mark F. Schnorr, Teresa M. MacKenzie, Barbara A. Luster, Michael I. |
| description | A comprehensive panel of immune parameters was evaluated among 145 lead‐exposed workers with a median blood lead level (BLL) of 39 μg/dL (range: 15–55 μg/dL) and 84 unexposed workers. After adjusting for covariates, we found no major differences in the percentage of CD3+ cells, CD4+ T cells, CD8+ T cells, B cells, or NK cells between lead‐exposed and unexposed workers, although the association between lead exposure and the number of CD4+ T cells was modified by age. We also found no differences between exposed and unexposed workers in serum immunoglobulin levels, salivary IgA, C3 complement levels, or lymphoproliferative responses. However, among exposed workers, the percentage and number of B cells were positively associated with current BLL, serum IgG was negatively associated with cumulative lead exposure, and the percentage and number of CD4+/CD45RA+ cells were positively associated with cumulative lead exposure. We found no evidence of a marked immunotoxic effect of lead at the exposure levels studied, although some subtle differences in immunologic parameters were noted. Am. J. Ind. Med. 33:400–408, 1998. Published 1998 Wiley‐Liss, Inc.
This article is a US Government work and, as such, is in the public domain in the United States of America. |
| doi_str_mv | 10.1002/(SICI)1097-0274(199804)33:4<400::AID-AJIM11>3.0.CO;2-2 |
| format | Article |
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This article is a US Government work and, as such, is in the public domain in the United States of America.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Chemical Analysis</subject><subject>CD4 Lymphocyte Count</subject><subject>CD4+ T lymphocyte</subject><subject>CD4-CD8 Ratio</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Cross-Sectional Studies</subject><subject>Environmental Monitoring - methods</subject><subject>Erythrocyte Count</subject><subject>Flow Cytometry</subject><subject>Humans</subject><subject>immune system</subject><subject>immunoglobulins</subject><subject>lead</subject><subject>Lead - adverse effects</subject><subject>Lead - blood</subject><subject>Logistic Models</subject><subject>Lymphocyte Activation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metallurgy</subject><subject>Metals and various inorganic compounds</subject><subject>Occupational Diseases - etiology</subject><subject>Occupational Diseases - immunology</subject><subject>Occupational Exposure - adverse effects</subject><subject>Reference Values</subject><subject>Surveys and Questionnaires</subject><subject>Toxicology</subject><issn>0271-3586</issn><issn>1097-0274</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkFtv00AQRlcIVELhJyDlAaH2wenM3uwNqFLkXnAJROL-Ntpu1pFbX4K3Udt_jy1beQGJp5F2vj377WHsFGGGAPzk6GuWZscIJo6Ax_IIjUlAHgsxl-8lwHy-yM6ixVX2CfFUzGCWrt7xiD9hk_2Vp2zSDYyESvRz9iKEGwBEqeUBOzAKhZbJhJ1kVbWrm7LZFG6aF_W6qDdhaqum3kxLb9eRf9g2wa-n901769vwkj3LbRn8q3Eesu8X59_SD9FydZmli2Xkugcwcg5BrznmFpQD6ZVHabRDLk2iY7BocsPBgUKvpcrja-GE596o2CjNYyEO2duBu22b3zsf7qgqgvNlaWvf7AKhllwbnnTBH0PQtU0Irc9p2xaVbR8JgXqTRL1J6rVQr4UGkyQESepMEnUmaTBJgoDSFXHiHfj12GB3Xfn1Hjuq6_Zvxr0NzpZ5a2tXhH2MY8xR9R_5NcTui9I__lXuP93-WW086dDRgC7CnX_Yo217SzoWsaKfny9pqa7S9AI-0hfxB7VOp9s</recordid><startdate>199804</startdate><enddate>199804</enddate><creator>Pinkerton, Lynne E.</creator><creator>Biagini, Raymond E.</creator><creator>Ward, Elizabeth M.</creator><creator>Hull, R. DeLon</creator><creator>Deddens, James A.</creator><creator>Boeniger, Mark F.</creator><creator>Schnorr, Teresa M.</creator><creator>MacKenzie, Barbara A.</creator><creator>Luster, Michael I.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>199804</creationdate><title>Immunologic findings among lead-exposed workers</title><author>Pinkerton, Lynne E. ; Biagini, Raymond E. ; Ward, Elizabeth M. ; Hull, R. 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After adjusting for covariates, we found no major differences in the percentage of CD3+ cells, CD4+ T cells, CD8+ T cells, B cells, or NK cells between lead‐exposed and unexposed workers, although the association between lead exposure and the number of CD4+ T cells was modified by age. We also found no differences between exposed and unexposed workers in serum immunoglobulin levels, salivary IgA, C3 complement levels, or lymphoproliferative responses. However, among exposed workers, the percentage and number of B cells were positively associated with current BLL, serum IgG was negatively associated with cumulative lead exposure, and the percentage and number of CD4+/CD45RA+ cells were positively associated with cumulative lead exposure. We found no evidence of a marked immunotoxic effect of lead at the exposure levels studied, although some subtle differences in immunologic parameters were noted. Am. J. Ind. Med. 33:400–408, 1998. Published 1998 Wiley‐Liss, Inc.
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| subjects | Adult Biological and medical sciences Blood Chemical Analysis CD4 Lymphocyte Count CD4+ T lymphocyte CD4-CD8 Ratio Chemical and industrial products toxicology. Toxic occupational diseases Cross-Sectional Studies Environmental Monitoring - methods Erythrocyte Count Flow Cytometry Humans immune system immunoglobulins lead Lead - adverse effects Lead - blood Logistic Models Lymphocyte Activation Male Medical sciences Metallurgy Metals and various inorganic compounds Occupational Diseases - etiology Occupational Diseases - immunology Occupational Exposure - adverse effects Reference Values Surveys and Questionnaires Toxicology |
| title | Immunologic findings among lead-exposed workers |
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