Cell-type dependent response of melanoma cells to aloe emodin

► Mechanism as well as the outcome of AE action against melanoma is defined by cell specificity. ► Induction of differentiation vs. apoptotic cell death is oppositely regulated by most important signals, ERK1/2 and Akt. ► Apoptotic cell death is triggered even in cells with permanently activated Akt...

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Veröffentlicht in:	Food and chemical toxicology 2012-09, Vol.50 (9), p.3181-3189
Hauptverfasser:	Radovic, J., Maksimovic-Ivanic, D., Timotijevic, G., Popadic, S., Ramic, Z., Trajkovic, V., Miljkovic, D., Stosic-Grujicic, S., Mijatovic, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt Aloe Aloe emodin Animals Anthraquinones - pharmacology Apoptosis Apoptosis - drug effects Biological and medical sciences caspases Cell Differentiation - drug effects Cell Line, Tumor cyclins Dermatology Differentiation dose response drug therapy emodin ERK1/2 Humans hydrogen peroxide inducible nitric oxide synthase MAP Kinase Signaling System Medical sciences melanin melanocytes Melanoma Melanoma, Experimental - enzymology Melanoma, Experimental - metabolism Melanoma, Experimental - pathology Mice Nitric Oxide Synthase Type II - metabolism patients Plant poisons toxicology Reactive Oxygen Species - metabolism signal transduction Toxicology Tumors of the skin and soft tissue. Premalignant lesions
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