Norepinephrine deficiency in Parkinson's disease: The case for noradrenergic enhancement

ABSTRACT The dramatic response of most motor and some nonmotor symptoms to dopaminergic therapies has contributed to maintaining the long‐established identity of Parkinson's disease (PD) as primarily a nigrostriatal dopamine (DA) deficiency syndrome. However, DA neurotransmission may be neither...

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Veröffentlicht in:	Movement disorders 2014-12, Vol.29 (14), p.1710-1719
Hauptverfasser:	Espay, Alberto J., LeWitt, Peter A., Kaufmann, Horacio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals autonomic Autonomic Nervous System Diseases - metabolism cognitive Dopamine - metabolism Dopamine beta-Hydroxylase - deficiency Dopamine beta-Hydroxylase - drug effects Dopamine beta-Hydroxylase - metabolism Humans locus coeruleus Locus Coeruleus - drug effects Locus Coeruleus - metabolism Motor Activity - drug effects Movement disorders norepinephrine Norepinephrine - deficiency Norepinephrine - metabolism Norepinephrine - pharmacology Parkinson Disease - drug therapy Parkinson Disease - genetics Parkinson's disease sleep disorders
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