Mortality Attributable to 9 Common Infections: Significant Effect of Influenza A, Respiratory Syncytial Virus, Influenza B, Norovirus, and Parainfluenza in Elderly Persons
Background. Because there may be substantial hidden mortality caused by common seasonal pathogens, we estimated the number of deaths in elderly persons attributable to viruses and bacteria for which robust weekly laboratory surveillance data were available. Methods. On weekly time series (1999-2007)...
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| Veröffentlicht in: | The Journal of infectious diseases 2012-09, Vol.206 (5), p.628-639 |
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| creator | van Asten, Liselotte van den Wijngaard, Cees van Pelt, Wilfrid van de Kassteele, Jan Meijer, Adam van der Hoek, Wim Kretzschmar, Mirjam Koopmans, Marion |
| description | Background. Because there may be substantial hidden mortality caused by common seasonal pathogens, we estimated the number of deaths in elderly persons attributable to viruses and bacteria for which robust weekly laboratory surveillance data were available. Methods. On weekly time series (1999-2007) we used regression models to associate total death counts in individuals aged 65-74, 75-84, and ≥85 years (a population of 2.5 million) with pathogen circulation—influenza A (season-specific), influenza B, respiratory syncytial virus (RSV), parainfluenza, enterovirus, rotavirus, norovirus, Campylobacter, and Salmonella — adjusted for extreme outdoor temperatures. Results. Influenza A and RSV were significantly (P |
| doi_str_mv | 10.1093/infdis/jis415 |
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Because there may be substantial hidden mortality caused by common seasonal pathogens, we estimated the number of deaths in elderly persons attributable to viruses and bacteria for which robust weekly laboratory surveillance data were available. Methods. On weekly time series (1999-2007) we used regression models to associate total death counts in individuals aged 65-74, 75-84, and ≥85 years (a population of 2.5 million) with pathogen circulation—influenza A (season-specific), influenza B, respiratory syncytial virus (RSV), parainfluenza, enterovirus, rotavirus, norovirus, Campylobacter, and Salmonella — adjusted for extreme outdoor temperatures. Results. Influenza A and RSV were significantly (P <.05) associated with mortality in all studied age groups; influenza B and parainfluenza were additionallyassociated in those aged ≥75 years, and norovirus was additionally associated in those aged ≥85 years. The proportions of deaths attributable to seasonal viruses were 6.8% (≥85 years), 4.4% (75-84 years), and 1.4% (65-74 years), but with great variations between years. Influenza occasionally showed lower impact than some of the other viruses. Conclusions. The number of different pathogens associated with mortality in the older population increases with increasing age. Besides influenza A and RSV, influenza B, parainfluenza and norovirus may also contribute substantially to elderly mortality.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jis415</identifier><identifier>PMID: 22723641</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Age groups ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Caliciviridae Infections - epidemiology ; Caliciviridae Infections - mortality ; Caliciviridae Infections - virology ; Campylobacter ; Campylobacter Infections - epidemiology ; Campylobacter Infections - microbiology ; Campylobacter Infections - mortality ; Death ; Enterovirus ; Enterovirus Infections - epidemiology ; Enterovirus Infections - mortality ; Enterovirus Infections - virology ; Fundamental and applied biological sciences. Psychology ; Human respiratory syncytial virus ; Humans ; Infections ; Infectious diseases ; Influenza A virus ; Influenza, Human - epidemiology ; Influenza, Human - mortality ; Influenza, Human - virology ; Medical sciences ; Microbiology ; Miscellaneous ; Mortality ; Netherlands - epidemiology ; Norovirus ; Older adults ; Paramyxoviridae Infections - epidemiology ; Paramyxoviridae Infections - mortality ; Paramyxoviridae Infections - virology ; Pathogens ; Regression Analysis ; Respiratory syncytial virus ; Respiratory Syncytial Virus Infections - epidemiology ; Respiratory Syncytial Virus Infections - mortality ; Respiratory Syncytial Virus Infections - virology ; Rotavirus ; Salmonella Infections - epidemiology ; Salmonella Infections - microbiology ; Salmonella Infections - mortality ; Salmonidae ; Seasons ; Virology ; Viruses</subject><ispartof>The Journal of infectious diseases, 2012-09, Vol.206 (5), p.628-639</ispartof><rights>Copyright © 2012 Oxford University Press on behalf of the Infectious Diseases Society of America</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-3f22798d5b09760399ba6f9cf225b0df1f96ec40c25d8cf5188308775d4696d3</citedby><cites>FETCH-LOGICAL-c483t-3f22798d5b09760399ba6f9cf225b0df1f96ec40c25d8cf5188308775d4696d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/41725660$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/41725660$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26287040$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22723641$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Asten, Liselotte</creatorcontrib><creatorcontrib>van den Wijngaard, Cees</creatorcontrib><creatorcontrib>van Pelt, Wilfrid</creatorcontrib><creatorcontrib>van de Kassteele, Jan</creatorcontrib><creatorcontrib>Meijer, Adam</creatorcontrib><creatorcontrib>van der Hoek, Wim</creatorcontrib><creatorcontrib>Kretzschmar, Mirjam</creatorcontrib><creatorcontrib>Koopmans, Marion</creatorcontrib><title>Mortality Attributable to 9 Common Infections: Significant Effect of Influenza A, Respiratory Syncytial Virus, Influenza B, Norovirus, and Parainfluenza in Elderly Persons</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Background. Because there may be substantial hidden mortality caused by common seasonal pathogens, we estimated the number of deaths in elderly persons attributable to viruses and bacteria for which robust weekly laboratory surveillance data were available. Methods. On weekly time series (1999-2007) we used regression models to associate total death counts in individuals aged 65-74, 75-84, and ≥85 years (a population of 2.5 million) with pathogen circulation—influenza A (season-specific), influenza B, respiratory syncytial virus (RSV), parainfluenza, enterovirus, rotavirus, norovirus, Campylobacter, and Salmonella — adjusted for extreme outdoor temperatures. Results. Influenza A and RSV were significantly (P <.05) associated with mortality in all studied age groups; influenza B and parainfluenza were additionallyassociated in those aged ≥75 years, and norovirus was additionally associated in those aged ≥85 years. The proportions of deaths attributable to seasonal viruses were 6.8% (≥85 years), 4.4% (75-84 years), and 1.4% (65-74 years), but with great variations between years. Influenza occasionally showed lower impact than some of the other viruses. Conclusions. The number of different pathogens associated with mortality in the older population increases with increasing age. Besides influenza A and RSV, influenza B, parainfluenza and norovirus may also contribute substantially to elderly mortality.</description><subject>Age groups</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Caliciviridae Infections - epidemiology</subject><subject>Caliciviridae Infections - mortality</subject><subject>Caliciviridae Infections - virology</subject><subject>Campylobacter</subject><subject>Campylobacter Infections - epidemiology</subject><subject>Campylobacter Infections - microbiology</subject><subject>Campylobacter Infections - mortality</subject><subject>Death</subject><subject>Enterovirus</subject><subject>Enterovirus Infections - epidemiology</subject><subject>Enterovirus Infections - mortality</subject><subject>Enterovirus Infections - virology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human respiratory syncytial virus</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Influenza A virus</subject><subject>Influenza, Human - epidemiology</subject><subject>Influenza, Human - mortality</subject><subject>Influenza, Human - virology</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Mortality</subject><subject>Netherlands - epidemiology</subject><subject>Norovirus</subject><subject>Older adults</subject><subject>Paramyxoviridae Infections - epidemiology</subject><subject>Paramyxoviridae Infections - mortality</subject><subject>Paramyxoviridae Infections - virology</subject><subject>Pathogens</subject><subject>Regression Analysis</subject><subject>Respiratory syncytial virus</subject><subject>Respiratory Syncytial Virus Infections - epidemiology</subject><subject>Respiratory Syncytial Virus Infections - mortality</subject><subject>Respiratory Syncytial Virus Infections - virology</subject><subject>Rotavirus</subject><subject>Salmonella Infections - epidemiology</subject><subject>Salmonella Infections - microbiology</subject><subject>Salmonella Infections - mortality</subject><subject>Salmonidae</subject><subject>Seasons</subject><subject>Virology</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U2P1CAYB3BiNO64evSo4WLiYeryVlq8jZNRN1l14268NpSCYUJhBGpSv5JfUiYdJ94MB5Ln-fEQ-APwHKM3GAl6Zb0ZbLra28Rw_QCscE2binNMH4IVQoRUuBXiAjxJaY8QYpQ3j8EFIQ2hnOEV-P0pxCydzTPc5BxtP2XZOw1zgAJuwzgGD6-90Srb4NNbeGe_e2uskj7DnTnWYTBH4Sbtf0m4WcOvOh1slDnEGd7NXs3ZSge_2Til9T_y3Rp-DjH8XOrSD_BWRmnPfevhzg06uhne6pjK7U_BIyNd0s9O-yW4f7-7336sbr58uN5ubirFWporasrzRDvUPRINR1SIXnIjVCmX0mCwEVwrhhSph1aZGrctRW3T1APjgg_0Erxexh5i-DHplLvRJqWdk16HKXWYM8IJbcr6L0WUlkBqxgqtFqpiSClq0x2iHWWcC-qOSXZLkt2SZPEvT6OnftTDWf-NroBXJyCTks5E6VU5fnactA1iqLgXi9unEsm5z3BDal6-5w9Bs7PG</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>van Asten, Liselotte</creator><creator>van den Wijngaard, Cees</creator><creator>van Pelt, Wilfrid</creator><creator>van de Kassteele, Jan</creator><creator>Meijer, Adam</creator><creator>van der Hoek, Wim</creator><creator>Kretzschmar, Mirjam</creator><creator>Koopmans, Marion</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T2</scope><scope>7U2</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>20120901</creationdate><title>Mortality Attributable to 9 Common Infections: Significant Effect of Influenza A, Respiratory Syncytial Virus, Influenza B, Norovirus, and Parainfluenza in Elderly Persons</title><author>van Asten, Liselotte ; van den Wijngaard, Cees ; van Pelt, Wilfrid ; van de Kassteele, Jan ; Meijer, Adam ; van der Hoek, Wim ; Kretzschmar, Mirjam ; Koopmans, Marion</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-3f22798d5b09760399ba6f9cf225b0df1f96ec40c25d8cf5188308775d4696d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Age groups</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Caliciviridae Infections - epidemiology</topic><topic>Caliciviridae Infections - mortality</topic><topic>Caliciviridae Infections - virology</topic><topic>Campylobacter</topic><topic>Campylobacter Infections - epidemiology</topic><topic>Campylobacter Infections - microbiology</topic><topic>Campylobacter Infections - mortality</topic><topic>Death</topic><topic>Enterovirus</topic><topic>Enterovirus Infections - epidemiology</topic><topic>Enterovirus Infections - mortality</topic><topic>Enterovirus Infections - virology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human respiratory syncytial virus</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Influenza A virus</topic><topic>Influenza, Human - epidemiology</topic><topic>Influenza, Human - mortality</topic><topic>Influenza, Human - virology</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Mortality</topic><topic>Netherlands - epidemiology</topic><topic>Norovirus</topic><topic>Older adults</topic><topic>Paramyxoviridae Infections - epidemiology</topic><topic>Paramyxoviridae Infections - mortality</topic><topic>Paramyxoviridae Infections - virology</topic><topic>Pathogens</topic><topic>Regression Analysis</topic><topic>Respiratory syncytial virus</topic><topic>Respiratory Syncytial Virus Infections - epidemiology</topic><topic>Respiratory Syncytial Virus Infections - mortality</topic><topic>Respiratory Syncytial Virus Infections - virology</topic><topic>Rotavirus</topic><topic>Salmonella Infections - epidemiology</topic><topic>Salmonella Infections - microbiology</topic><topic>Salmonella Infections - mortality</topic><topic>Salmonidae</topic><topic>Seasons</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Asten, Liselotte</creatorcontrib><creatorcontrib>van den Wijngaard, Cees</creatorcontrib><creatorcontrib>van Pelt, Wilfrid</creatorcontrib><creatorcontrib>van de Kassteele, Jan</creatorcontrib><creatorcontrib>Meijer, Adam</creatorcontrib><creatorcontrib>van der Hoek, Wim</creatorcontrib><creatorcontrib>Kretzschmar, Mirjam</creatorcontrib><creatorcontrib>Koopmans, Marion</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Asten, Liselotte</au><au>van den Wijngaard, Cees</au><au>van Pelt, Wilfrid</au><au>van de Kassteele, Jan</au><au>Meijer, Adam</au><au>van der Hoek, Wim</au><au>Kretzschmar, Mirjam</au><au>Koopmans, Marion</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mortality Attributable to 9 Common Infections: Significant Effect of Influenza A, Respiratory Syncytial Virus, Influenza B, Norovirus, and Parainfluenza in Elderly Persons</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2012-09-01</date><risdate>2012</risdate><volume>206</volume><issue>5</issue><spage>628</spage><epage>639</epage><pages>628-639</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Background. Because there may be substantial hidden mortality caused by common seasonal pathogens, we estimated the number of deaths in elderly persons attributable to viruses and bacteria for which robust weekly laboratory surveillance data were available. Methods. On weekly time series (1999-2007) we used regression models to associate total death counts in individuals aged 65-74, 75-84, and ≥85 years (a population of 2.5 million) with pathogen circulation—influenza A (season-specific), influenza B, respiratory syncytial virus (RSV), parainfluenza, enterovirus, rotavirus, norovirus, Campylobacter, and Salmonella — adjusted for extreme outdoor temperatures. Results. Influenza A and RSV were significantly (P <.05) associated with mortality in all studied age groups; influenza B and parainfluenza were additionallyassociated in those aged ≥75 years, and norovirus was additionally associated in those aged ≥85 years. The proportions of deaths attributable to seasonal viruses were 6.8% (≥85 years), 4.4% (75-84 years), and 1.4% (65-74 years), but with great variations between years. Influenza occasionally showed lower impact than some of the other viruses. Conclusions. The number of different pathogens associated with mortality in the older population increases with increasing age. Besides influenza A and RSV, influenza B, parainfluenza and norovirus may also contribute substantially to elderly mortality.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>22723641</pmid><doi>10.1093/infdis/jis415</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age groups Aged Aged, 80 and over Biological and medical sciences Caliciviridae Infections - epidemiology Caliciviridae Infections - mortality Caliciviridae Infections - virology Campylobacter Campylobacter Infections - epidemiology Campylobacter Infections - microbiology Campylobacter Infections - mortality Death Enterovirus Enterovirus Infections - epidemiology Enterovirus Infections - mortality Enterovirus Infections - virology Fundamental and applied biological sciences. Psychology Human respiratory syncytial virus Humans Infections Infectious diseases Influenza A virus Influenza, Human - epidemiology Influenza, Human - mortality Influenza, Human - virology Medical sciences Microbiology Miscellaneous Mortality Netherlands - epidemiology Norovirus Older adults Paramyxoviridae Infections - epidemiology Paramyxoviridae Infections - mortality Paramyxoviridae Infections - virology Pathogens Regression Analysis Respiratory syncytial virus Respiratory Syncytial Virus Infections - epidemiology Respiratory Syncytial Virus Infections - mortality Respiratory Syncytial Virus Infections - virology Rotavirus Salmonella Infections - epidemiology Salmonella Infections - microbiology Salmonella Infections - mortality Salmonidae Seasons Virology Viruses |
| title | Mortality Attributable to 9 Common Infections: Significant Effect of Influenza A, Respiratory Syncytial Virus, Influenza B, Norovirus, and Parainfluenza in Elderly Persons |
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