Stat5 gene dosage in T cells modulates CD8+ T‐cell homeostasis and attenuates contact hypersensitivity response in mice

Background Contact hypersensitivity assay (CHS) faithfully models human allergies. The Stat5 transcription factors are essential for both lymphocyte development and acute immune responses. Although consequences of Stat5 ablation and transgenic overexpression for the lymphocyte development and functi...

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Veröffentlicht in:	Allergy (Copenhagen) 2015-01, Vol.70 (1), p.67-79
Hauptverfasser:	Nivarthi, H., Prchal‐Murphy, M., Swoboda, A., Hager, M., Schlederer, M., Kenner, L., Tuckermann, J., Sexl, V., Moriggl, R., Ermakova, O.
Format:	Artikel
Sprache:	eng
Schlagworte:	allergic contact dermatitis Allergies Animals CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Dermatitis, Contact - blood Dermatitis, Contact - genetics Dermatitis, Contact - immunology Disease Models, Animal Gene Dosage Genes Germ Cells - metabolism Haploinsufficiency Homeostasis Leukocyte Count Lymphocyte Activation - genetics Lymphocyte Activation - immunology Lymphocyte Count Lymphocytes Mice Mice, Transgenic Rodents Stat5 STAT5 Transcription Factor - genetics T cells Thymus Gland - immunology Thymus Gland - metabolism Transcription factors
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