Safety and immunogenicity of a modified-vaccinia-virus-Ankara-based influenza A H5N1 vaccine: a randomised, double-blind phase 1/2a clinical trial

Summary Background Modified vaccinia virus Ankara (MVA) is a promising viral vector platform for the development of an H5N1 influenza vaccine. Preclinical assessment of MVA-based H5N1 vaccines showed their immunogenicity and safety in different animal models. We aimed to assess the safety and immuno...

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Veröffentlicht in:	The Lancet infectious diseases 2014-12, Vol.14 (12), p.1196-1207
Hauptverfasser:	Kreijtz, Joost H C M, PhD, Goeijenbier, Marco, MD, Moesker, Fleur M, MD, van den Dries, Lennert, MD, Goeijenbier, Simone, BSc, De Gruyter, Heidi L M, BSc, Lehmann, Michael H, PhD, Mutsert, Gerrie de, BSc, van de Vijver, David A M C, PhD, Volz, Asisa, PhD, Fouchier, Ron A M, Prof, van Gorp, Eric C M, Prof, Rimmelzwaan, Guus F, Prof, Sutter, Gerd, Prof, Osterhaus, Albert D M E, Prof
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Animal models Animals Antibodies, Viral - blood Biological and medical sciences Body temperature Clinical trials Double-Blind Method Drug Carriers Drug-Related Side Effects and Adverse Reactions - epidemiology Drug-Related Side Effects and Adverse Reactions - pathology Female Genetic Vectors Healthy Volunteers Hemagglutination Inhibition Tests Hemagglutinin Glycoproteins, Influenza Virus - genetics Hemagglutinin Glycoproteins, Influenza Virus - immunology Human viral diseases Humans Immunization Immunogenicity Immunology Infectious Disease Infectious diseases Influenza A Virus, H5N1 Subtype - genetics Influenza A Virus, H5N1 Subtype - immunology Influenza Vaccines - administration & dosage Influenza Vaccines - adverse effects Influenza Vaccines - genetics Influenza Vaccines - immunology Injection Injections, Intramuscular Male Medical sciences Pandemics Safety Vaccines Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - adverse effects Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Vaccinia virus Vaccinia virus - genetics Viral diseases Viral diseases of the respiratory system and ent viral diseases Viruses Young Adult
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