MicroRNA-590 attenuates lipid accumulation and pro-inflammatory cytokine secretion by targeting lipoprotein lipase gene in human THP-1 macrophages

Accumulating evidence suggests that microRNA-590 (miR-590) has protective effects on cardiovascular diseases, but the mechanism is unknown. Interestingly, previous studies from our laboratory and others have shown that macrophage-derived lipoprotein lipase (LPL) might accelerate atherosclerosis by p...

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Veröffentlicht in:	Biochimie 2014-11, Vol.106, p.81-90
Hauptverfasser:	He, Ping-Ping, Ouyang, Xin-Ping, Tang, Yan-Yan, Liao, Li, Wang, Zong-Bao, Lv, Yun-Cheng, Tian, Guo-Ping, Zhao, Guo-Jun, Huang, Liang, Yao, Feng, Xie, Wei, Tang, Yu Lin, Chen, Wu-Jun, Zhang, Min, Li, Yuan, Wu, Jian-Feng, Peng, Juan, Liu, Xiang-Yu, Zheng, Xi-Long, Yin, Wei-Dong, Tang, Chao-Ke
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Atherosclerosis Base Sequence Blotting, Western Cell Line, Tumor Cytokines - secretion Gene Expression HEK293 Cells Human THP-1 macrophages Humans Inflammation Mediators - metabolism Lipids - analysis Lipoprotein Lipase - genetics Lipoprotein Lipase - metabolism Lipoproteins, LDL - pharmacology LPL Macrophages - drug effects Macrophages - metabolism MicroRNAs - genetics MiR-590 Reverse Transcriptase Polymerase Chain Reaction RNA Interference Sequence Homology, Nucleic Acid
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