Immunohistochemical mapping of neuropeptide Y in the tree shrew brain
ABSTRACT Day‐active tree shrews are promising animals as research models for a variety of human disorders. Neuropeptide Y (NPY) modulates many behaviors in vertebrates. Here we examined the distribution of NPY in the brain of tree shrews (Tupaia belangeri chinensis) using immunohistochemical techniq...
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| Veröffentlicht in: | Journal of comparative neurology (1911) 2015-02, Vol.523 (3), p.495-529 |
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| container_title | Journal of comparative neurology (1911) |
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| creator | Ni, Rong-Jun Shu, Yu-Mian Luo, Peng-Hao Fang, Hui Wang, Yu Yao, Lei Zhou, Jiang-Ning |
| description | ABSTRACT
Day‐active tree shrews are promising animals as research models for a variety of human disorders. Neuropeptide Y (NPY) modulates many behaviors in vertebrates. Here we examined the distribution of NPY in the brain of tree shrews (Tupaia belangeri chinensis) using immunohistochemical techniques. The differential distribution of NPY‐immunoreactive (‐ir) cells and fibers were observed in the rhinencephalon, telencephalon, diencephalon, mesencephalon, metencephalon, and myelencephalon of tree shrews. Most NPY‐ir cells were multipolar or bipolar in shape with triangular, fusiform, and/or globular perikarya. The densest cluster of NPY‐ir cells were found in the mitral cell layer of the main olfactory bulb (MOB), arcuate nucleus of the hypothalamus, and pretectal nucleus of the thalamus. The MOB presented a unique pattern of NPY immunoreactivity. Laminar distribution of NPY‐ir cells was observed in the MOB, neocortex, and hippocampus. Compared to rats, the tree shrews exhibited a particularly robust and widespread distribution of NPY‐ir cells in the MOB, bed nucleus of the stria terminalis, and amygdala as well as the ventral lateral geniculate nucleus and pretectal nucleus of the thalamus. By contrast, a low density of neurons were scattered in the striatum, neocortex, polymorph cell layer of the dentate gyrus, superior colliculus, inferior colliculus, and dorsal tegmental nucleus. These findings provide the first detailed mapping of NPY immunoreactivity in the tree shrew brain and demonstrate species differences in the distribution of this neuropeptide, providing an anatomical basis for the participation of the NPY system in the regulation of numerous physiological and behavioral processes. J. Comp. Neurol. 523:495–529, 2015. © 2014 Wiley Periodicals, Inc.
Using immunohistochemical techniques, the authors provide the first detailed mapping of neuropeptide Y immunoreactivity in the tree shrew brains and semi‐quantitative analysis of immunoreactive cell and fiber density in the tree shrew and rat brains. These findings demonstrate species differences in the distribution of neuropeptide Y. |
| doi_str_mv | 10.1002/cne.23696 |
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Day‐active tree shrews are promising animals as research models for a variety of human disorders. Neuropeptide Y (NPY) modulates many behaviors in vertebrates. Here we examined the distribution of NPY in the brain of tree shrews (Tupaia belangeri chinensis) using immunohistochemical techniques. The differential distribution of NPY‐immunoreactive (‐ir) cells and fibers were observed in the rhinencephalon, telencephalon, diencephalon, mesencephalon, metencephalon, and myelencephalon of tree shrews. Most NPY‐ir cells were multipolar or bipolar in shape with triangular, fusiform, and/or globular perikarya. The densest cluster of NPY‐ir cells were found in the mitral cell layer of the main olfactory bulb (MOB), arcuate nucleus of the hypothalamus, and pretectal nucleus of the thalamus. The MOB presented a unique pattern of NPY immunoreactivity. Laminar distribution of NPY‐ir cells was observed in the MOB, neocortex, and hippocampus. Compared to rats, the tree shrews exhibited a particularly robust and widespread distribution of NPY‐ir cells in the MOB, bed nucleus of the stria terminalis, and amygdala as well as the ventral lateral geniculate nucleus and pretectal nucleus of the thalamus. By contrast, a low density of neurons were scattered in the striatum, neocortex, polymorph cell layer of the dentate gyrus, superior colliculus, inferior colliculus, and dorsal tegmental nucleus. These findings provide the first detailed mapping of NPY immunoreactivity in the tree shrew brain and demonstrate species differences in the distribution of this neuropeptide, providing an anatomical basis for the participation of the NPY system in the regulation of numerous physiological and behavioral processes. J. Comp. Neurol. 523:495–529, 2015. © 2014 Wiley Periodicals, Inc.
Using immunohistochemical techniques, the authors provide the first detailed mapping of neuropeptide Y immunoreactivity in the tree shrew brains and semi‐quantitative analysis of immunoreactive cell and fiber density in the tree shrew and rat brains. These findings demonstrate species differences in the distribution of neuropeptide Y.</description><identifier>ISSN: 0021-9967</identifier><identifier>EISSN: 1096-9861</identifier><identifier>DOI: 10.1002/cne.23696</identifier><identifier>PMID: 25327585</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>AB_2313977 ; Acetylthiocholine - metabolism ; amygdala ; Animals ; basal ganglia ; Brain - anatomy & histology ; Brain - metabolism ; Brain Mapping ; hippocampus ; hypothalamus ; Male ; Neuropeptide Y - metabolism ; olfactory bulb ; Signal Processing, Computer-Assisted ; Tupaia ; Tupaia belangeri ; Tupaiidae ; Vasopressins - metabolism ; ventral tegmental area</subject><ispartof>Journal of comparative neurology (1911), 2015-02, Vol.523 (3), p.495-529</ispartof><rights>2014 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4596-11a1ac8d83c038a23d3ebefcecee755be76f0917ad243f1e5db6bc0661afdca23</citedby><cites>FETCH-LOGICAL-c4596-11a1ac8d83c038a23d3ebefcecee755be76f0917ad243f1e5db6bc0661afdca23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcne.23696$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcne.23696$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25327585$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ni, Rong-Jun</creatorcontrib><creatorcontrib>Shu, Yu-Mian</creatorcontrib><creatorcontrib>Luo, Peng-Hao</creatorcontrib><creatorcontrib>Fang, Hui</creatorcontrib><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Yao, Lei</creatorcontrib><creatorcontrib>Zhou, Jiang-Ning</creatorcontrib><title>Immunohistochemical mapping of neuropeptide Y in the tree shrew brain</title><title>Journal of comparative neurology (1911)</title><addtitle>J. Comp. Neurol</addtitle><description>ABSTRACT
Day‐active tree shrews are promising animals as research models for a variety of human disorders. Neuropeptide Y (NPY) modulates many behaviors in vertebrates. Here we examined the distribution of NPY in the brain of tree shrews (Tupaia belangeri chinensis) using immunohistochemical techniques. The differential distribution of NPY‐immunoreactive (‐ir) cells and fibers were observed in the rhinencephalon, telencephalon, diencephalon, mesencephalon, metencephalon, and myelencephalon of tree shrews. Most NPY‐ir cells were multipolar or bipolar in shape with triangular, fusiform, and/or globular perikarya. The densest cluster of NPY‐ir cells were found in the mitral cell layer of the main olfactory bulb (MOB), arcuate nucleus of the hypothalamus, and pretectal nucleus of the thalamus. The MOB presented a unique pattern of NPY immunoreactivity. Laminar distribution of NPY‐ir cells was observed in the MOB, neocortex, and hippocampus. Compared to rats, the tree shrews exhibited a particularly robust and widespread distribution of NPY‐ir cells in the MOB, bed nucleus of the stria terminalis, and amygdala as well as the ventral lateral geniculate nucleus and pretectal nucleus of the thalamus. By contrast, a low density of neurons were scattered in the striatum, neocortex, polymorph cell layer of the dentate gyrus, superior colliculus, inferior colliculus, and dorsal tegmental nucleus. These findings provide the first detailed mapping of NPY immunoreactivity in the tree shrew brain and demonstrate species differences in the distribution of this neuropeptide, providing an anatomical basis for the participation of the NPY system in the regulation of numerous physiological and behavioral processes. J. Comp. Neurol. 523:495–529, 2015. © 2014 Wiley Periodicals, Inc.
Using immunohistochemical techniques, the authors provide the first detailed mapping of neuropeptide Y immunoreactivity in the tree shrew brains and semi‐quantitative analysis of immunoreactive cell and fiber density in the tree shrew and rat brains. These findings demonstrate species differences in the distribution of neuropeptide Y.</description><subject>AB_2313977</subject><subject>Acetylthiocholine - metabolism</subject><subject>amygdala</subject><subject>Animals</subject><subject>basal ganglia</subject><subject>Brain - anatomy & histology</subject><subject>Brain - metabolism</subject><subject>Brain Mapping</subject><subject>hippocampus</subject><subject>hypothalamus</subject><subject>Male</subject><subject>Neuropeptide Y - metabolism</subject><subject>olfactory bulb</subject><subject>Signal Processing, Computer-Assisted</subject><subject>Tupaia</subject><subject>Tupaia belangeri</subject><subject>Tupaiidae</subject><subject>Vasopressins - metabolism</subject><subject>ventral tegmental area</subject><issn>0021-9967</issn><issn>1096-9861</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0U1LHDEYB_AgFd2qB79ACfTSHkaTySSZHMuy7i6IFXxZPIVM5pludN6azKB-e6PrehAKPeWQ3_Mnef4IHVNyQglJT20LJykTSuygCSVKJCoX9AuaxDuaKCXkPvoawj0hRCmW76H9lLNU8pxP0GzZNGPbrV0YOruGxllT48b0vWv_4K7CLYy-66EfXAn4DrsWD2vAgwfAYe3hERfeuPYQ7VamDnD0fh6gm7PZ9XSRnP-eL6e_zhOb8fgsSg01Ni9zZgnLTcpKBgVUFiyA5LwAKSqiqDRlmrGKAi8LUVgiBDVVaaM_QD82ub3v_o4QBt24YKGuTQvdGDQVWSpoznL2H5RJpbhUJNLvn-h9N_o2fuRViUxk7E393CjruxA8VLr3rjH-WVOiX2vQsQb9VkO0394Tx6KB8kNu9x7B6QY8uhqe_52kpxezbWSymYhNwdPHhPEPWkgmuV5dzPVqfn25uL3imrMX6UygLw</recordid><startdate>20150215</startdate><enddate>20150215</enddate><creator>Ni, Rong-Jun</creator><creator>Shu, Yu-Mian</creator><creator>Luo, Peng-Hao</creator><creator>Fang, Hui</creator><creator>Wang, Yu</creator><creator>Yao, Lei</creator><creator>Zhou, Jiang-Ning</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20150215</creationdate><title>Immunohistochemical mapping of neuropeptide Y in the tree shrew brain</title><author>Ni, Rong-Jun ; Shu, Yu-Mian ; Luo, Peng-Hao ; Fang, Hui ; Wang, Yu ; Yao, Lei ; Zhou, Jiang-Ning</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4596-11a1ac8d83c038a23d3ebefcecee755be76f0917ad243f1e5db6bc0661afdca23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>AB_2313977</topic><topic>Acetylthiocholine - metabolism</topic><topic>amygdala</topic><topic>Animals</topic><topic>basal ganglia</topic><topic>Brain - anatomy & histology</topic><topic>Brain - metabolism</topic><topic>Brain Mapping</topic><topic>hippocampus</topic><topic>hypothalamus</topic><topic>Male</topic><topic>Neuropeptide Y - metabolism</topic><topic>olfactory bulb</topic><topic>Signal Processing, Computer-Assisted</topic><topic>Tupaia</topic><topic>Tupaia belangeri</topic><topic>Tupaiidae</topic><topic>Vasopressins - metabolism</topic><topic>ventral tegmental area</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ni, Rong-Jun</creatorcontrib><creatorcontrib>Shu, Yu-Mian</creatorcontrib><creatorcontrib>Luo, Peng-Hao</creatorcontrib><creatorcontrib>Fang, Hui</creatorcontrib><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Yao, Lei</creatorcontrib><creatorcontrib>Zhou, Jiang-Ning</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of comparative neurology (1911)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ni, Rong-Jun</au><au>Shu, Yu-Mian</au><au>Luo, Peng-Hao</au><au>Fang, Hui</au><au>Wang, Yu</au><au>Yao, Lei</au><au>Zhou, Jiang-Ning</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunohistochemical mapping of neuropeptide Y in the tree shrew brain</atitle><jtitle>Journal of comparative neurology (1911)</jtitle><addtitle>J. Comp. Neurol</addtitle><date>2015-02-15</date><risdate>2015</risdate><volume>523</volume><issue>3</issue><spage>495</spage><epage>529</epage><pages>495-529</pages><issn>0021-9967</issn><eissn>1096-9861</eissn><abstract>ABSTRACT
Day‐active tree shrews are promising animals as research models for a variety of human disorders. Neuropeptide Y (NPY) modulates many behaviors in vertebrates. Here we examined the distribution of NPY in the brain of tree shrews (Tupaia belangeri chinensis) using immunohistochemical techniques. The differential distribution of NPY‐immunoreactive (‐ir) cells and fibers were observed in the rhinencephalon, telencephalon, diencephalon, mesencephalon, metencephalon, and myelencephalon of tree shrews. Most NPY‐ir cells were multipolar or bipolar in shape with triangular, fusiform, and/or globular perikarya. The densest cluster of NPY‐ir cells were found in the mitral cell layer of the main olfactory bulb (MOB), arcuate nucleus of the hypothalamus, and pretectal nucleus of the thalamus. The MOB presented a unique pattern of NPY immunoreactivity. Laminar distribution of NPY‐ir cells was observed in the MOB, neocortex, and hippocampus. Compared to rats, the tree shrews exhibited a particularly robust and widespread distribution of NPY‐ir cells in the MOB, bed nucleus of the stria terminalis, and amygdala as well as the ventral lateral geniculate nucleus and pretectal nucleus of the thalamus. By contrast, a low density of neurons were scattered in the striatum, neocortex, polymorph cell layer of the dentate gyrus, superior colliculus, inferior colliculus, and dorsal tegmental nucleus. These findings provide the first detailed mapping of NPY immunoreactivity in the tree shrew brain and demonstrate species differences in the distribution of this neuropeptide, providing an anatomical basis for the participation of the NPY system in the regulation of numerous physiological and behavioral processes. J. Comp. Neurol. 523:495–529, 2015. © 2014 Wiley Periodicals, Inc.
Using immunohistochemical techniques, the authors provide the first detailed mapping of neuropeptide Y immunoreactivity in the tree shrew brains and semi‐quantitative analysis of immunoreactive cell and fiber density in the tree shrew and rat brains. These findings demonstrate species differences in the distribution of neuropeptide Y.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25327585</pmid><doi>10.1002/cne.23696</doi><tpages>35</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | AB_2313977 Acetylthiocholine - metabolism amygdala Animals basal ganglia Brain - anatomy & histology Brain - metabolism Brain Mapping hippocampus hypothalamus Male Neuropeptide Y - metabolism olfactory bulb Signal Processing, Computer-Assisted Tupaia Tupaia belangeri Tupaiidae Vasopressins - metabolism ventral tegmental area |
| title | Immunohistochemical mapping of neuropeptide Y in the tree shrew brain |
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