Oral immunotherapy induces IgG antibodies that act through FcγRIIb to suppress IgE-mediated hypersensitivity

Background Food-induced anaphylaxis is triggered by specific IgE antibodies. Paradoxically, some subjects with significant IgE levels can ingest allergenic foods without incident. Similarly, subjects completing oral immunotherapy (OIT) tolerate food challenges despite persistent high-titer food-spec...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2014-12, Vol.134 (6), p.1310-1317.e6
Hauptverfasser:	Burton, Oliver T., PhD, Logsdon, Stephanie L., MD, Zhou, Joseph S., MD, PhD, Medina-Tamayo, Jaciel, PhD, Abdel-Gadir, Azza, PhD, Noval Rivas, Magali, PhD, Koleoglou, Kyle J, Chatila, Talal A., MD, MSc, Schneider, Lynda C., MD, Rachid, Rima, MD, Umetsu, Dale T., MD, PhD, Oettgen, Hans C., MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adolescent Allergens - immunology Allergic diseases Allergy and Immunology anaphylaxis Animals Arachis hypogaea Basophils - immunology Biological and medical sciences Child desensitization Desensitization, Immunologic Digestive allergic diseases Female Food Food allergy Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Hypersensitivity, Immediate - blood Hypersensitivity, Immediate - immunology Hypersensitivity, Immediate - therapy IgE Immunoglobulin G - blood Immunoglobulin G - immunology Immunopathology Male Mast Cells - immunology Medical sciences Mice, Transgenic oral immunotherapy Ovalbumin - immunology Receptors, IgG - immunology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis tolerance
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