DNA Looping Provides for “Intersegmental Hopping” by Proteins: A Mechanism for Long-Range Site Localization

Studies on how transcription factors and DNA modifying enzymes passively locate specific sites on DNA have yet to be reconciled with a sufficient set of mechanisms that can adequately account for the efficiency and speed of this process. This is especially true when considering that these DNA bindin...

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Veröffentlicht in:	Journal of molecular biology 2014-10, Vol.426 (21), p.3539-3552
Hauptverfasser:	Pollak, Adam J., Chin, Aaron T., Brown, Frank L.H., Reich, Norbert O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - chemistry Binding Sites - genetics DNA - chemistry DNA Methylation DNA methyltransferase DNA Restriction Enzymes - chemistry DNA structure Escherichia coli - enzymology facilitated diffusion Genome intersegmental transfer Molecular Conformation processivity Protein Binding Site-Specific DNA-Methyltransferase (Adenine-Specific) - chemistry
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