Divergent effects of the H50Q and G51D SNCA mutations on the aggregation of α‐synuclein

The discoveries of mutations in SNCA were seminal findings that resulted in the knowledge that α‐synuclein (αS) is the major component of Parkinson's disease‐associated Lewy bodies. Since the pathologic roles of these protein inclusions and SNCA mutations are not completely established, we char...

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Veröffentlicht in:	Journal of neurochemistry 2014-12, Vol.131 (6), p.859-867
Hauptverfasser:	Rutherford, Nicola J., Moore, Brenda D., Golde, Todd E., Giasson, Benoit I.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - genetics alpha-Synuclein - metabolism Amyloid - metabolism Cells, Cultured Humans Mutation - genetics Parkinson Disease - genetics Parkinson Disease - metabolism Parkinson's disease Protein Aggregates - genetics protein aggregation SNCA mutation α‐synuclein
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