Risk factors for early intrahepatic distant recurrence after radiofrequency ablation for hepatocellular carcinoma in Egyptian patients
Objective Early tumor recurrence, either local or intrahepatic distant recurrence (IDR), after successful radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) remains a significant problem. The study aimed to determine the potential risk factors for IDR within one year after successful R...
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| Veröffentlicht in: | Journal of digestive diseases 2014-12, Vol.15 (12), p.676-683 |
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| creator | Montasser, Mohammed Fawzy Shaker, Mohamed Kamal Albreedy, Ashraf M Montasser, Iman Fawzy El Dorry, Ahmed |
| description | Objective
Early tumor recurrence, either local or intrahepatic distant recurrence (IDR), after successful radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) remains a significant problem. The study aimed to determine the potential risk factors for IDR within one year after successful RFA in HCC patients.
Methods
In total, 105 patients with 138 lesions who underwent RFA and were followed up for at least one year were included in this study. The patients' data was retrospectively reviewed. Multiple host and tumoral potential risk factors were analyzed.
Results
IDR was found in 62 (59.0%) of all patients. Cumulative IDR‐free survival rates in all patients studied were 81.9%, 45.4% and 35.2% at 1, 2 and 3 years, respectively, after RFA. Univariate and multivariate analysis showed that both tumor size >2.8 cm and primary multinodular tumors were significant risk factors for IDR within one year after RFA.
Conclusions
Patients with tumors of >2.8 cm in diameter or multinodular HCC should be closely monitored for early recurrence after RFA. Combined or systemic therapies should be tried for these patients to improve their disease‐free and overall survival. |
| doi_str_mv | 10.1111/1751-2980.12190 |
| format | Article |
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Early tumor recurrence, either local or intrahepatic distant recurrence (IDR), after successful radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) remains a significant problem. The study aimed to determine the potential risk factors for IDR within one year after successful RFA in HCC patients.
Methods
In total, 105 patients with 138 lesions who underwent RFA and were followed up for at least one year were included in this study. The patients' data was retrospectively reviewed. Multiple host and tumoral potential risk factors were analyzed.
Results
IDR was found in 62 (59.0%) of all patients. Cumulative IDR‐free survival rates in all patients studied were 81.9%, 45.4% and 35.2% at 1, 2 and 3 years, respectively, after RFA. Univariate and multivariate analysis showed that both tumor size >2.8 cm and primary multinodular tumors were significant risk factors for IDR within one year after RFA.
Conclusions
Patients with tumors of >2.8 cm in diameter or multinodular HCC should be closely monitored for early recurrence after RFA. Combined or systemic therapies should be tried for these patients to improve their disease‐free and overall survival.</description><identifier>ISSN: 1751-2972</identifier><identifier>EISSN: 1751-2980</identifier><identifier>DOI: 10.1111/1751-2980.12190</identifier><identifier>PMID: 25214183</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Adult ; Bile Duct Neoplasms - mortality ; Bile Duct Neoplasms - secondary ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - secondary ; Carcinoma, Hepatocellular - surgery ; Catheter Ablation ; Disease-Free Survival ; Egypt ; Female ; Follow-Up Studies ; Humans ; intrahepatic distant recurrence ; Liver cancer ; Liver cirrhosis ; liver neoplasms ; Liver Neoplasms - pathology ; Liver Neoplasms - surgery ; Male ; Middle Aged ; Multivariate analysis ; Neoplasm Recurrence, Local - mortality ; Neoplasm Recurrence, Local - pathology ; radiofrequency ablation ; Retrospective Studies ; Risk Factors ; risk factors, survival ; survival ; Survival Rate ; Treatment Outcome ; Tumors</subject><ispartof>Journal of digestive diseases, 2014-12, Vol.15 (12), p.676-683</ispartof><rights>2014 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd</rights><rights>2014 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.</rights><rights>Journal of Digestive Diseases © 2014 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1751-2980.12190$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1751-2980.12190$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25214183$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Montasser, Mohammed Fawzy</creatorcontrib><creatorcontrib>Shaker, Mohamed Kamal</creatorcontrib><creatorcontrib>Albreedy, Ashraf M</creatorcontrib><creatorcontrib>Montasser, Iman Fawzy</creatorcontrib><creatorcontrib>El Dorry, Ahmed</creatorcontrib><title>Risk factors for early intrahepatic distant recurrence after radiofrequency ablation for hepatocellular carcinoma in Egyptian patients</title><title>Journal of digestive diseases</title><addtitle>Journal of Digestive Diseases</addtitle><description>Objective
Early tumor recurrence, either local or intrahepatic distant recurrence (IDR), after successful radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) remains a significant problem. The study aimed to determine the potential risk factors for IDR within one year after successful RFA in HCC patients.
Methods
In total, 105 patients with 138 lesions who underwent RFA and were followed up for at least one year were included in this study. The patients' data was retrospectively reviewed. Multiple host and tumoral potential risk factors were analyzed.
Results
IDR was found in 62 (59.0%) of all patients. Cumulative IDR‐free survival rates in all patients studied were 81.9%, 45.4% and 35.2% at 1, 2 and 3 years, respectively, after RFA. Univariate and multivariate analysis showed that both tumor size >2.8 cm and primary multinodular tumors were significant risk factors for IDR within one year after RFA.
Conclusions
Patients with tumors of >2.8 cm in diameter or multinodular HCC should be closely monitored for early recurrence after RFA. Combined or systemic therapies should be tried for these patients to improve their disease‐free and overall survival.</description><subject>Adult</subject><subject>Bile Duct Neoplasms - mortality</subject><subject>Bile Duct Neoplasms - secondary</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - secondary</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Catheter Ablation</subject><subject>Disease-Free Survival</subject><subject>Egypt</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>intrahepatic distant recurrence</subject><subject>Liver cancer</subject><subject>Liver cirrhosis</subject><subject>liver neoplasms</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Neoplasm Recurrence, Local - mortality</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>radiofrequency ablation</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>risk factors, survival</subject><subject>survival</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>1751-2972</issn><issn>1751-2980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU9v1DAQxS0EoqVw5oYsceES8J_Yzh5hW1pEVSQE6tGaODa4zdqL7ajNF-Bz4-yWPdQXe8a_9zSah9BrSt7Tej5QJWjDVl0tGV2RJ-j40Hl6eCt2hF7kfEOIkKqTz9ERE4y2tOPH6O93n2-xA1NiytjFhC2kccY-lAS_7RaKN3jwuUAoOFkzpWSDsRhcsQknGHx0yf6ZanPG0I-Vj2HnsxNHY8dxGiFhA8n4EDdQrfHZr3lbPAS8-NtQ8kv0zMGY7auH-wT9_Hz2Y33RXH47_7L-eNl4zjhp2AArRpQceuFED6KzxDG-sqrWnaHCKW4FFwNva4cr0lvJewaDpIa41hl-gt7tfbcp1qFz0Ruflxkh2DhlTWXLJKWMsIq-fYTexCmFOp2mSsmWqFaQSr15oKZ-Ywe9TX4Dadb_N1wBsQfu_Gjnwz8leglQLxHpJS69C1CvT093j6pr9rq6e3t_0EG61VJxJfT11blm7Os1uZCftOD_AKADneU</recordid><startdate>201412</startdate><enddate>201412</enddate><creator>Montasser, Mohammed Fawzy</creator><creator>Shaker, Mohamed Kamal</creator><creator>Albreedy, Ashraf M</creator><creator>Montasser, Iman Fawzy</creator><creator>El Dorry, Ahmed</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201412</creationdate><title>Risk factors for early intrahepatic distant recurrence after radiofrequency ablation for hepatocellular carcinoma in Egyptian patients</title><author>Montasser, Mohammed Fawzy ; Shaker, Mohamed Kamal ; Albreedy, Ashraf M ; Montasser, Iman Fawzy ; El Dorry, Ahmed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3230-2da92076db5f5ba58e0f239e7b5f8c15f73e535d347b5370be63b2ad61c0f4fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Bile Duct Neoplasms - mortality</topic><topic>Bile Duct Neoplasms - secondary</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Carcinoma, Hepatocellular - secondary</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Catheter Ablation</topic><topic>Disease-Free Survival</topic><topic>Egypt</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>intrahepatic distant recurrence</topic><topic>Liver cancer</topic><topic>Liver cirrhosis</topic><topic>liver neoplasms</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - surgery</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Neoplasm Recurrence, Local - mortality</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>radiofrequency ablation</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>risk factors, survival</topic><topic>survival</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Montasser, Mohammed Fawzy</creatorcontrib><creatorcontrib>Shaker, Mohamed Kamal</creatorcontrib><creatorcontrib>Albreedy, Ashraf M</creatorcontrib><creatorcontrib>Montasser, Iman Fawzy</creatorcontrib><creatorcontrib>El Dorry, Ahmed</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of digestive diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Montasser, Mohammed Fawzy</au><au>Shaker, Mohamed Kamal</au><au>Albreedy, Ashraf M</au><au>Montasser, Iman Fawzy</au><au>El Dorry, Ahmed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors for early intrahepatic distant recurrence after radiofrequency ablation for hepatocellular carcinoma in Egyptian patients</atitle><jtitle>Journal of digestive diseases</jtitle><addtitle>Journal of Digestive Diseases</addtitle><date>2014-12</date><risdate>2014</risdate><volume>15</volume><issue>12</issue><spage>676</spage><epage>683</epage><pages>676-683</pages><issn>1751-2972</issn><eissn>1751-2980</eissn><abstract>Objective
Early tumor recurrence, either local or intrahepatic distant recurrence (IDR), after successful radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) remains a significant problem. The study aimed to determine the potential risk factors for IDR within one year after successful RFA in HCC patients.
Methods
In total, 105 patients with 138 lesions who underwent RFA and were followed up for at least one year were included in this study. The patients' data was retrospectively reviewed. Multiple host and tumoral potential risk factors were analyzed.
Results
IDR was found in 62 (59.0%) of all patients. Cumulative IDR‐free survival rates in all patients studied were 81.9%, 45.4% and 35.2% at 1, 2 and 3 years, respectively, after RFA. Univariate and multivariate analysis showed that both tumor size >2.8 cm and primary multinodular tumors were significant risk factors for IDR within one year after RFA.
Conclusions
Patients with tumors of >2.8 cm in diameter or multinodular HCC should be closely monitored for early recurrence after RFA. Combined or systemic therapies should be tried for these patients to improve their disease‐free and overall survival.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>25214183</pmid><doi>10.1111/1751-2980.12190</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Bile Duct Neoplasms - mortality Bile Duct Neoplasms - secondary Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - secondary Carcinoma, Hepatocellular - surgery Catheter Ablation Disease-Free Survival Egypt Female Follow-Up Studies Humans intrahepatic distant recurrence Liver cancer Liver cirrhosis liver neoplasms Liver Neoplasms - pathology Liver Neoplasms - surgery Male Middle Aged Multivariate analysis Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - pathology radiofrequency ablation Retrospective Studies Risk Factors risk factors, survival survival Survival Rate Treatment Outcome Tumors |
| title | Risk factors for early intrahepatic distant recurrence after radiofrequency ablation for hepatocellular carcinoma in Egyptian patients |
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