Socio-economic deprivation and outcomes following radical nephroureterectomy for clinically localized upper tract transitional cell carcinoma
Background Little is known about the effects of socio-economic deprivation on the oncological outcomes of surgically treated upper tract transitional cell carcinoma. Methods From January 1998 to December 2012, 161 patients underwent nephroureterectomy for upper urinary tract cancer at our tertiary m...
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| Veröffentlicht in: | World journal of urology 2015-01, Vol.33 (1), p.41-49 |
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| creator | Mehta, R. Gillan, A. S. Ming, Z. Y. Rai, B. P. Byrne, D. Nabi, G. |
| description | Background
Little is known about the effects of socio-economic deprivation on the oncological outcomes of surgically treated upper tract transitional cell carcinoma.
Methods
From January 1998 to December 2012, 161 patients underwent nephroureterectomy for upper urinary tract cancer at our tertiary medical centre. We included 124 patients where complete data were available for further analysis. This study also analysed the impact of the reported risk factors such as grade, stage, multifocality in addition to socio-economic deprivation on the long-term oncological outcomes after nephroureterectomy.
Results
One hundred and twenty-four (77 %) patients with complete data for socio-economic status were analysed in this study. The median age of the cohort was 73 years (interquartile range 45–86). There were 20, 18, 17, 40 and 29 patients in different socio-economic categories ranging from 1 to 5, respectively. The median duration of follow-up was 68 months (9–174). A statistically higher grade (
p
value 0.005) and higher stage (
p
value 0.0005) disease was seen in patients from less deprived categories on both univariate and multivariate analyses. The cancer-specific mortality and follow-up recurrences, however, did not significantly differ between the different socio-economic categories on multivariate analysis (
p
value 0.13; 0.6) and on univariate and multivariate analyses. A higher number of patients with multifocal disease and concomitant carcinoma in situ (CIS) had disease recurrences which were statistically significant (
p
values 0.026 and 0.014, respectively) on multivariate analysis.
Conclusions
A lower recurrence-free survival was observed in patients with multifocal disease and those with concomitant CIS following nephroureterectomy for clinically localized disease. Long-term follow-up did not show any significant differences in cancer-specific survival between different deprivation categories. |
| doi_str_mv | 10.1007/s00345-014-1262-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1642609969</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3543832701</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-9c3c605c09324d6a79e4659f3a72af57052eb610cf8164cd586bfca856beabb73</originalsourceid><addsrcrecordid>eNp1kctu1TAQhi0EoqeFB2CDLLFhYxg7jh0vUcVNqsQCWFuOMymuEjvYCdXhHXhnHE5BCInNzGK--efyE_KEwwsOoF8WgEa2DLhkXCjB4B45cNk0rNNC3ScH0EIyabrmjJyXcgPAtYL2ITkTUnEDYA7kx8fkQ2LoU0xz8HTAJYdvbg0pUhcHmrbVpxkLHdM0pdsQr2l2Q_BuohGXLzltGVfM6Nc0HyuUqZ9C3OvTkU6p5vAdB7otC2a6ZufXPcYS9glVxONUg8s-1PnuEXkwuqng47t8QT6_ef3p8h27-vD2_eWrK-alFCszvvH1EA-mEXJQThuUqjVj47RwY6uhFdgrDn7suJJ-aDvVj951rerR9b1uLsjzk-6S09cNy2rnUPZVXMS0FVu7hAJjlKnos3_Qm3pzXf0XxTU3bScqxU-Uz6mUjKOtb5xdPloOdvfKnryy1Su7e2Wh9jy9U976GYc_Hb_NqYA4AaWW4jXmv0b_V_Un2e6ijg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1641719582</pqid></control><display><type>article</type><title>Socio-economic deprivation and outcomes following radical nephroureterectomy for clinically localized upper tract transitional cell carcinoma</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Mehta, R. ; Gillan, A. S. ; Ming, Z. Y. ; Rai, B. P. ; Byrne, D. ; Nabi, G.</creator><creatorcontrib>Mehta, R. ; Gillan, A. S. ; Ming, Z. Y. ; Rai, B. P. ; Byrne, D. ; Nabi, G. ; Tayside Urological Cancers Network, Dundee, Scotland ; Tayside Urological Cancers Network, Dundee, Scotland</creatorcontrib><description>Background
Little is known about the effects of socio-economic deprivation on the oncological outcomes of surgically treated upper tract transitional cell carcinoma.
Methods
From January 1998 to December 2012, 161 patients underwent nephroureterectomy for upper urinary tract cancer at our tertiary medical centre. We included 124 patients where complete data were available for further analysis. This study also analysed the impact of the reported risk factors such as grade, stage, multifocality in addition to socio-economic deprivation on the long-term oncological outcomes after nephroureterectomy.
Results
One hundred and twenty-four (77 %) patients with complete data for socio-economic status were analysed in this study. The median age of the cohort was 73 years (interquartile range 45–86). There were 20, 18, 17, 40 and 29 patients in different socio-economic categories ranging from 1 to 5, respectively. The median duration of follow-up was 68 months (9–174). A statistically higher grade (
p
value 0.005) and higher stage (
p
value 0.0005) disease was seen in patients from less deprived categories on both univariate and multivariate analyses. The cancer-specific mortality and follow-up recurrences, however, did not significantly differ between the different socio-economic categories on multivariate analysis (
p
value 0.13; 0.6) and on univariate and multivariate analyses. A higher number of patients with multifocal disease and concomitant carcinoma in situ (CIS) had disease recurrences which were statistically significant (
p
values 0.026 and 0.014, respectively) on multivariate analysis.
Conclusions
A lower recurrence-free survival was observed in patients with multifocal disease and those with concomitant CIS following nephroureterectomy for clinically localized disease. Long-term follow-up did not show any significant differences in cancer-specific survival between different deprivation categories.</description><identifier>ISSN: 0724-4983</identifier><identifier>EISSN: 1433-8726</identifier><identifier>DOI: 10.1007/s00345-014-1262-0</identifier><identifier>PMID: 24619009</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Aged, 80 and over ; Carcinoma, Transitional Cell - mortality ; Carcinoma, Transitional Cell - pathology ; Carcinoma, Transitional Cell - surgery ; Cohort Studies ; Female ; Humans ; Kidney Neoplasms - mortality ; Kidney Neoplasms - pathology ; Kidney Neoplasms - surgery ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Nephrectomy ; Nephrology ; Oncology ; Original Article ; Risk Factors ; Social Class ; Survival Analysis ; Treatment Outcome ; Ureteral Neoplasms - mortality ; Ureteral Neoplasms - pathology ; Ureteral Neoplasms - surgery ; Urology</subject><ispartof>World journal of urology, 2015-01, Vol.33 (1), p.41-49</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-9c3c605c09324d6a79e4659f3a72af57052eb610cf8164cd586bfca856beabb73</citedby><cites>FETCH-LOGICAL-c442t-9c3c605c09324d6a79e4659f3a72af57052eb610cf8164cd586bfca856beabb73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00345-014-1262-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00345-014-1262-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24619009$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mehta, R.</creatorcontrib><creatorcontrib>Gillan, A. S.</creatorcontrib><creatorcontrib>Ming, Z. Y.</creatorcontrib><creatorcontrib>Rai, B. P.</creatorcontrib><creatorcontrib>Byrne, D.</creatorcontrib><creatorcontrib>Nabi, G.</creatorcontrib><creatorcontrib>Tayside Urological Cancers Network, Dundee, Scotland</creatorcontrib><creatorcontrib>Tayside Urological Cancers Network, Dundee, Scotland</creatorcontrib><title>Socio-economic deprivation and outcomes following radical nephroureterectomy for clinically localized upper tract transitional cell carcinoma</title><title>World journal of urology</title><addtitle>World J Urol</addtitle><addtitle>World J Urol</addtitle><description>Background
Little is known about the effects of socio-economic deprivation on the oncological outcomes of surgically treated upper tract transitional cell carcinoma.
Methods
From January 1998 to December 2012, 161 patients underwent nephroureterectomy for upper urinary tract cancer at our tertiary medical centre. We included 124 patients where complete data were available for further analysis. This study also analysed the impact of the reported risk factors such as grade, stage, multifocality in addition to socio-economic deprivation on the long-term oncological outcomes after nephroureterectomy.
Results
One hundred and twenty-four (77 %) patients with complete data for socio-economic status were analysed in this study. The median age of the cohort was 73 years (interquartile range 45–86). There were 20, 18, 17, 40 and 29 patients in different socio-economic categories ranging from 1 to 5, respectively. The median duration of follow-up was 68 months (9–174). A statistically higher grade (
p
value 0.005) and higher stage (
p
value 0.0005) disease was seen in patients from less deprived categories on both univariate and multivariate analyses. The cancer-specific mortality and follow-up recurrences, however, did not significantly differ between the different socio-economic categories on multivariate analysis (
p
value 0.13; 0.6) and on univariate and multivariate analyses. A higher number of patients with multifocal disease and concomitant carcinoma in situ (CIS) had disease recurrences which were statistically significant (
p
values 0.026 and 0.014, respectively) on multivariate analysis.
Conclusions
A lower recurrence-free survival was observed in patients with multifocal disease and those with concomitant CIS following nephroureterectomy for clinically localized disease. Long-term follow-up did not show any significant differences in cancer-specific survival between different deprivation categories.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Transitional Cell - mortality</subject><subject>Carcinoma, Transitional Cell - pathology</subject><subject>Carcinoma, Transitional Cell - surgery</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Kidney Neoplasms - mortality</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidney Neoplasms - surgery</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nephrectomy</subject><subject>Nephrology</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Risk Factors</subject><subject>Social Class</subject><subject>Survival Analysis</subject><subject>Treatment Outcome</subject><subject>Ureteral Neoplasms - mortality</subject><subject>Ureteral Neoplasms - pathology</subject><subject>Ureteral Neoplasms - surgery</subject><subject>Urology</subject><issn>0724-4983</issn><issn>1433-8726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kctu1TAQhi0EoqeFB2CDLLFhYxg7jh0vUcVNqsQCWFuOMymuEjvYCdXhHXhnHE5BCInNzGK--efyE_KEwwsOoF8WgEa2DLhkXCjB4B45cNk0rNNC3ScH0EIyabrmjJyXcgPAtYL2ITkTUnEDYA7kx8fkQ2LoU0xz8HTAJYdvbg0pUhcHmrbVpxkLHdM0pdsQr2l2Q_BuohGXLzltGVfM6Nc0HyuUqZ9C3OvTkU6p5vAdB7otC2a6ZufXPcYS9glVxONUg8s-1PnuEXkwuqng47t8QT6_ef3p8h27-vD2_eWrK-alFCszvvH1EA-mEXJQThuUqjVj47RwY6uhFdgrDn7suJJ-aDvVj951rerR9b1uLsjzk-6S09cNy2rnUPZVXMS0FVu7hAJjlKnos3_Qm3pzXf0XxTU3bScqxU-Uz6mUjKOtb5xdPloOdvfKnryy1Su7e2Wh9jy9U976GYc_Hb_NqYA4AaWW4jXmv0b_V_Un2e6ijg</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Mehta, R.</creator><creator>Gillan, A. S.</creator><creator>Ming, Z. Y.</creator><creator>Rai, B. P.</creator><creator>Byrne, D.</creator><creator>Nabi, G.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20150101</creationdate><title>Socio-economic deprivation and outcomes following radical nephroureterectomy for clinically localized upper tract transitional cell carcinoma</title><author>Mehta, R. ; Gillan, A. S. ; Ming, Z. Y. ; Rai, B. P. ; Byrne, D. ; Nabi, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-9c3c605c09324d6a79e4659f3a72af57052eb610cf8164cd586bfca856beabb73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Transitional Cell - mortality</topic><topic>Carcinoma, Transitional Cell - pathology</topic><topic>Carcinoma, Transitional Cell - surgery</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Kidney Neoplasms - mortality</topic><topic>Kidney Neoplasms - pathology</topic><topic>Kidney Neoplasms - surgery</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nephrectomy</topic><topic>Nephrology</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Risk Factors</topic><topic>Social Class</topic><topic>Survival Analysis</topic><topic>Treatment Outcome</topic><topic>Ureteral Neoplasms - mortality</topic><topic>Ureteral Neoplasms - pathology</topic><topic>Ureteral Neoplasms - surgery</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mehta, R.</creatorcontrib><creatorcontrib>Gillan, A. S.</creatorcontrib><creatorcontrib>Ming, Z. Y.</creatorcontrib><creatorcontrib>Rai, B. P.</creatorcontrib><creatorcontrib>Byrne, D.</creatorcontrib><creatorcontrib>Nabi, G.</creatorcontrib><creatorcontrib>Tayside Urological Cancers Network, Dundee, Scotland</creatorcontrib><creatorcontrib>Tayside Urological Cancers Network, Dundee, Scotland</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>World journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mehta, R.</au><au>Gillan, A. S.</au><au>Ming, Z. Y.</au><au>Rai, B. P.</au><au>Byrne, D.</au><au>Nabi, G.</au><aucorp>Tayside Urological Cancers Network, Dundee, Scotland</aucorp><aucorp>Tayside Urological Cancers Network, Dundee, Scotland</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Socio-economic deprivation and outcomes following radical nephroureterectomy for clinically localized upper tract transitional cell carcinoma</atitle><jtitle>World journal of urology</jtitle><stitle>World J Urol</stitle><addtitle>World J Urol</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>33</volume><issue>1</issue><spage>41</spage><epage>49</epage><pages>41-49</pages><issn>0724-4983</issn><eissn>1433-8726</eissn><abstract>Background
Little is known about the effects of socio-economic deprivation on the oncological outcomes of surgically treated upper tract transitional cell carcinoma.
Methods
From January 1998 to December 2012, 161 patients underwent nephroureterectomy for upper urinary tract cancer at our tertiary medical centre. We included 124 patients where complete data were available for further analysis. This study also analysed the impact of the reported risk factors such as grade, stage, multifocality in addition to socio-economic deprivation on the long-term oncological outcomes after nephroureterectomy.
Results
One hundred and twenty-four (77 %) patients with complete data for socio-economic status were analysed in this study. The median age of the cohort was 73 years (interquartile range 45–86). There were 20, 18, 17, 40 and 29 patients in different socio-economic categories ranging from 1 to 5, respectively. The median duration of follow-up was 68 months (9–174). A statistically higher grade (
p
value 0.005) and higher stage (
p
value 0.0005) disease was seen in patients from less deprived categories on both univariate and multivariate analyses. The cancer-specific mortality and follow-up recurrences, however, did not significantly differ between the different socio-economic categories on multivariate analysis (
p
value 0.13; 0.6) and on univariate and multivariate analyses. A higher number of patients with multifocal disease and concomitant carcinoma in situ (CIS) had disease recurrences which were statistically significant (
p
values 0.026 and 0.014, respectively) on multivariate analysis.
Conclusions
A lower recurrence-free survival was observed in patients with multifocal disease and those with concomitant CIS following nephroureterectomy for clinically localized disease. Long-term follow-up did not show any significant differences in cancer-specific survival between different deprivation categories.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24619009</pmid><doi>10.1007/s00345-014-1262-0</doi><tpages>9</tpages></addata></record> |
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| ispartof | World journal of urology, 2015-01, Vol.33 (1), p.41-49 |
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| subjects | Aged Aged, 80 and over Carcinoma, Transitional Cell - mortality Carcinoma, Transitional Cell - pathology Carcinoma, Transitional Cell - surgery Cohort Studies Female Humans Kidney Neoplasms - mortality Kidney Neoplasms - pathology Kidney Neoplasms - surgery Male Medicine Medicine & Public Health Middle Aged Nephrectomy Nephrology Oncology Original Article Risk Factors Social Class Survival Analysis Treatment Outcome Ureteral Neoplasms - mortality Ureteral Neoplasms - pathology Ureteral Neoplasms - surgery Urology |
| title | Socio-economic deprivation and outcomes following radical nephroureterectomy for clinically localized upper tract transitional cell carcinoma |
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