Highly Viscous Antibody Solutions Are a Consequence of Network Formation Caused by Domain–Domain Electrostatic Complementarities: Insights from Coarse-Grained Simulations

Therapeutic monoclonal antibody (mAb) candidates that form highly viscous solutions at concentrations above 100 mg/mL can lead to challenges in bioprocessing, formulation development, and subcutaneous drug delivery. Earlier studies of mAbs with concentration-dependent high viscosity have indicated t...

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Veröffentlicht in:	Molecular pharmaceutics 2015-01, Vol.12 (1), p.127-139
Hauptverfasser:	Buck, Patrick M, Chaudhri, Anuj, Kumar, Sandeep, Singh, Satish K
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies - chemistry Antibodies, Monoclonal - chemistry Diffusion Drug Delivery Systems Humans Hydrogen-Ion Concentration Immunoglobulin G - chemistry Materials Testing Molecular Dynamics Simulation Pharmaceutical Solutions Protein Structure, Tertiary Static Electricity Surface Properties Viscosity
Online-Zugang:	Volltext
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