A split face study to document the safety and efficacy of clearance of melasma with a 5 ns q switched Nd YAG laser versus a 50 ns q switched Nd YAG laser
Background and Objectives To determine the safety and efficacy of a 50 ns Q switched Nd YAG laser vs. a 5 ns Q switched Nd YAG laser for clearance of melasma. To compare subject satisfaction, efficacy, and comfort level between the two lasers. Study Design/Materials and Methods This is a prospective...
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| Veröffentlicht in: | Lasers in surgery and medicine 2014-12, Vol.46 (10), p.736-740 |
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| creator | Alsaad, Salman M. S. Ross, E. Victor Mishra, Vineet Miller, Lee |
| description | Background and Objectives
To determine the safety and efficacy of a 50 ns Q switched Nd YAG laser vs. a 5 ns Q switched Nd YAG laser for clearance of melasma. To compare subject satisfaction, efficacy, and comfort level between the two lasers.
Study Design/Materials and Methods
This is a prospective, randomized split face clinical study. The study was approved by the Scripps IRB. Ten healthy female subjects with moderate to severe melasma were enrolled. Each subject had three laser treatments one month apart. Patients were followed up approximately 1 month, 3 months, and 6 months after the final laser treatment. A treatment session consisted of a microdermabrasion, 1064 nm QS laser, and topicals. Subjects were asked to rate treatment pain based on a numerical scale range 0–10 (0 = no pain and 10 = worst pain). A melasma area and severity index (MASI) grading system was applied. Also, melanin measurements were acquired by a reflectance spectrophotometer. Side effects were documented during the study including post treatment erythema.
Results
Eight patients completed the study. Subjects showed improvement on both sides of the face. From baseline to 1 month post the final laser treatment, the average MASI scores showed a 16% reduction for the 50 ns QS 1064 nm laser vs. a 27% reduction for the 5 ns QS 1064 nm laser (both significant versus baseline pigment, P |
| doi_str_mv | 10.1002/lsm.22303 |
| format | Article |
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To determine the safety and efficacy of a 50 ns Q switched Nd YAG laser vs. a 5 ns Q switched Nd YAG laser for clearance of melasma. To compare subject satisfaction, efficacy, and comfort level between the two lasers.
Study Design/Materials and Methods
This is a prospective, randomized split face clinical study. The study was approved by the Scripps IRB. Ten healthy female subjects with moderate to severe melasma were enrolled. Each subject had three laser treatments one month apart. Patients were followed up approximately 1 month, 3 months, and 6 months after the final laser treatment. A treatment session consisted of a microdermabrasion, 1064 nm QS laser, and topicals. Subjects were asked to rate treatment pain based on a numerical scale range 0–10 (0 = no pain and 10 = worst pain). A melasma area and severity index (MASI) grading system was applied. Also, melanin measurements were acquired by a reflectance spectrophotometer. Side effects were documented during the study including post treatment erythema.
Results
Eight patients completed the study. Subjects showed improvement on both sides of the face. From baseline to 1 month post the final laser treatment, the average MASI scores showed a 16% reduction for the 50 ns QS 1064 nm laser vs. a 27% reduction for the 5 ns QS 1064 nm laser (both significant versus baseline pigment, P < 0.05). This difference in MASI scores between the two lasers was not statistically significant (P = 0.87930). Laser treatments displayed mild erythema that resolved after one day. The melanin meter measurements showed a reduction in pigment readings on both sides. Three months after the final treatment there was some relapse in the melasma, as the mean pigment reduction fell to 12% for the 50 ns laser and 11% for the 5 ns laser. By 3 months pigment reduction was not statistically significant for either laser, and no significant differences in pigment reduction were noted between the two pulse durations. There was a statistically significant difference (P < 0.05) in pain scores reported by the subjects (scale 0–10), the mean pain score for 50 ns QS 1064 nm laser was 1.2 and for the 5 ns QS 2.9 the score was 2.9.
Conclusions
In this study, we showed that a combination of microdermabrasion, QS1064 nm laser, and topicals decreased the MASI and meter scores without clinically significant side effects. Moreover, the longer pulsed Q switched 1064 nm laser i.e. (50 ns) was associated with less pain than its shorter pulse width counterpart. Lasers Surg. Med. 46:736–740, 2014. © 2014 Wiley Periodicals, Inc.</description><identifier>ISSN: 0196-8092</identifier><identifier>EISSN: 1096-9101</identifier><identifier>DOI: 10.1002/lsm.22303</identifier><identifier>PMID: 25411141</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Dermabrasion ; Face ; Female ; Follow-Up Studies ; Humans ; Laser Therapy - adverse effects ; Laser Therapy - instrumentation ; Lasers, Solid-State - therapeutic use ; Male ; Melanosis - pathology ; Melanosis - surgery ; melasma ; Middle Aged ; Prospective Studies ; QS Nd: YAG 1064 nm laser ; Treatment Outcome ; Young Adult</subject><ispartof>Lasers in surgery and medicine, 2014-12, Vol.46 (10), p.736-740</ispartof><rights>2014 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3473-8afee2c14c9bc8dd47ffd4eab44ba32e62f9fc89282777b2a8c4679249f1c1ba3</citedby><cites>FETCH-LOGICAL-c3473-8afee2c14c9bc8dd47ffd4eab44ba32e62f9fc89282777b2a8c4679249f1c1ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flsm.22303$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flsm.22303$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27933,27934,45583,45584</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25411141$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alsaad, Salman M. S.</creatorcontrib><creatorcontrib>Ross, E. Victor</creatorcontrib><creatorcontrib>Mishra, Vineet</creatorcontrib><creatorcontrib>Miller, Lee</creatorcontrib><title>A split face study to document the safety and efficacy of clearance of melasma with a 5 ns q switched Nd YAG laser versus a 50 ns q switched Nd YAG laser</title><title>Lasers in surgery and medicine</title><addtitle>Lasers Surg. Med</addtitle><description>Background and Objectives
To determine the safety and efficacy of a 50 ns Q switched Nd YAG laser vs. a 5 ns Q switched Nd YAG laser for clearance of melasma. To compare subject satisfaction, efficacy, and comfort level between the two lasers.
Study Design/Materials and Methods
This is a prospective, randomized split face clinical study. The study was approved by the Scripps IRB. Ten healthy female subjects with moderate to severe melasma were enrolled. Each subject had three laser treatments one month apart. Patients were followed up approximately 1 month, 3 months, and 6 months after the final laser treatment. A treatment session consisted of a microdermabrasion, 1064 nm QS laser, and topicals. Subjects were asked to rate treatment pain based on a numerical scale range 0–10 (0 = no pain and 10 = worst pain). A melasma area and severity index (MASI) grading system was applied. Also, melanin measurements were acquired by a reflectance spectrophotometer. Side effects were documented during the study including post treatment erythema.
Results
Eight patients completed the study. Subjects showed improvement on both sides of the face. From baseline to 1 month post the final laser treatment, the average MASI scores showed a 16% reduction for the 50 ns QS 1064 nm laser vs. a 27% reduction for the 5 ns QS 1064 nm laser (both significant versus baseline pigment, P < 0.05). This difference in MASI scores between the two lasers was not statistically significant (P = 0.87930). Laser treatments displayed mild erythema that resolved after one day. The melanin meter measurements showed a reduction in pigment readings on both sides. Three months after the final treatment there was some relapse in the melasma, as the mean pigment reduction fell to 12% for the 50 ns laser and 11% for the 5 ns laser. By 3 months pigment reduction was not statistically significant for either laser, and no significant differences in pigment reduction were noted between the two pulse durations. There was a statistically significant difference (P < 0.05) in pain scores reported by the subjects (scale 0–10), the mean pain score for 50 ns QS 1064 nm laser was 1.2 and for the 5 ns QS 2.9 the score was 2.9.
Conclusions
In this study, we showed that a combination of microdermabrasion, QS1064 nm laser, and topicals decreased the MASI and meter scores without clinically significant side effects. Moreover, the longer pulsed Q switched 1064 nm laser i.e. (50 ns) was associated with less pain than its shorter pulse width counterpart. Lasers Surg. Med. 46:736–740, 2014. © 2014 Wiley Periodicals, Inc.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Dermabrasion</subject><subject>Face</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Laser Therapy - adverse effects</subject><subject>Laser Therapy - instrumentation</subject><subject>Lasers, Solid-State - therapeutic use</subject><subject>Male</subject><subject>Melanosis - pathology</subject><subject>Melanosis - surgery</subject><subject>melasma</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>QS Nd: YAG 1064 nm laser</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0196-8092</issn><issn>1096-9101</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctuFDEQRS0EIkNgwQ-gWsKiE9vtfng5imBAmgSkGRSxstx2WdPQj4ntJvSOLR_Bz_ElcZgkO1jVQ-deleoS8pLRE0YpP-1Cf8J5TvNHZMGoLDPJKHtMFpSlvqaSH5FnIXyllOacVk_JES8EY0ywBfm9hLDv2ghOG4QQJztDHMGOZupxiBB3aasdxhn0YAGda402M4wOTIfa6yHJ0tBjp0Ov4bqNO9BQ_Pn5awhwBSEtzA4tXFj4slxBotDDd_RhCrcc_S_4nDxxugv44q4ek8_v3m7P3mfrj6sPZ8t1ZnJR5VmdDkRumDCyMbW1onLOCtSNEI3OOZbcSWdqyWteVVXDdW1EWUkupGOGJeSYvD747v14NWGIqm-Dwa7TA45TUKwUvEyPrYuEvjmgxo8heHRq79te-1kxqm7TUCkN9TeNxL66s52aHu0Def_-BJwegOu2w_nfTmq9Ob-3zA6KNkT88aDQ_psqq7wq1OXFSm22n7ZrublURX4Dfg2lMQ</recordid><startdate>201412</startdate><enddate>201412</enddate><creator>Alsaad, Salman M. S.</creator><creator>Ross, E. Victor</creator><creator>Mishra, Vineet</creator><creator>Miller, Lee</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201412</creationdate><title>A split face study to document the safety and efficacy of clearance of melasma with a 5 ns q switched Nd YAG laser versus a 50 ns q switched Nd YAG laser</title><author>Alsaad, Salman M. S. ; Ross, E. Victor ; Mishra, Vineet ; Miller, Lee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3473-8afee2c14c9bc8dd47ffd4eab44ba32e62f9fc89282777b2a8c4679249f1c1ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Dermabrasion</topic><topic>Face</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Laser Therapy - adverse effects</topic><topic>Laser Therapy - instrumentation</topic><topic>Lasers, Solid-State - therapeutic use</topic><topic>Male</topic><topic>Melanosis - pathology</topic><topic>Melanosis - surgery</topic><topic>melasma</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>QS Nd: YAG 1064 nm laser</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alsaad, Salman M. S.</creatorcontrib><creatorcontrib>Ross, E. Victor</creatorcontrib><creatorcontrib>Mishra, Vineet</creatorcontrib><creatorcontrib>Miller, Lee</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Lasers in surgery and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alsaad, Salman M. S.</au><au>Ross, E. Victor</au><au>Mishra, Vineet</au><au>Miller, Lee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A split face study to document the safety and efficacy of clearance of melasma with a 5 ns q switched Nd YAG laser versus a 50 ns q switched Nd YAG laser</atitle><jtitle>Lasers in surgery and medicine</jtitle><addtitle>Lasers Surg. Med</addtitle><date>2014-12</date><risdate>2014</risdate><volume>46</volume><issue>10</issue><spage>736</spage><epage>740</epage><pages>736-740</pages><issn>0196-8092</issn><eissn>1096-9101</eissn><abstract>Background and Objectives
To determine the safety and efficacy of a 50 ns Q switched Nd YAG laser vs. a 5 ns Q switched Nd YAG laser for clearance of melasma. To compare subject satisfaction, efficacy, and comfort level between the two lasers.
Study Design/Materials and Methods
This is a prospective, randomized split face clinical study. The study was approved by the Scripps IRB. Ten healthy female subjects with moderate to severe melasma were enrolled. Each subject had three laser treatments one month apart. Patients were followed up approximately 1 month, 3 months, and 6 months after the final laser treatment. A treatment session consisted of a microdermabrasion, 1064 nm QS laser, and topicals. Subjects were asked to rate treatment pain based on a numerical scale range 0–10 (0 = no pain and 10 = worst pain). A melasma area and severity index (MASI) grading system was applied. Also, melanin measurements were acquired by a reflectance spectrophotometer. Side effects were documented during the study including post treatment erythema.
Results
Eight patients completed the study. Subjects showed improvement on both sides of the face. From baseline to 1 month post the final laser treatment, the average MASI scores showed a 16% reduction for the 50 ns QS 1064 nm laser vs. a 27% reduction for the 5 ns QS 1064 nm laser (both significant versus baseline pigment, P < 0.05). This difference in MASI scores between the two lasers was not statistically significant (P = 0.87930). Laser treatments displayed mild erythema that resolved after one day. The melanin meter measurements showed a reduction in pigment readings on both sides. Three months after the final treatment there was some relapse in the melasma, as the mean pigment reduction fell to 12% for the 50 ns laser and 11% for the 5 ns laser. By 3 months pigment reduction was not statistically significant for either laser, and no significant differences in pigment reduction were noted between the two pulse durations. There was a statistically significant difference (P < 0.05) in pain scores reported by the subjects (scale 0–10), the mean pain score for 50 ns QS 1064 nm laser was 1.2 and for the 5 ns QS 2.9 the score was 2.9.
Conclusions
In this study, we showed that a combination of microdermabrasion, QS1064 nm laser, and topicals decreased the MASI and meter scores without clinically significant side effects. Moreover, the longer pulsed Q switched 1064 nm laser i.e. (50 ns) was associated with less pain than its shorter pulse width counterpart. Lasers Surg. Med. 46:736–740, 2014. © 2014 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25411141</pmid><doi>10.1002/lsm.22303</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0196-8092 |
| ispartof | Lasers in surgery and medicine, 2014-12, Vol.46 (10), p.736-740 |
| issn | 0196-8092 1096-9101 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adolescent Adult Aged Dermabrasion Face Female Follow-Up Studies Humans Laser Therapy - adverse effects Laser Therapy - instrumentation Lasers, Solid-State - therapeutic use Male Melanosis - pathology Melanosis - surgery melasma Middle Aged Prospective Studies QS Nd: YAG 1064 nm laser Treatment Outcome Young Adult |
| title | A split face study to document the safety and efficacy of clearance of melasma with a 5 ns q switched Nd YAG laser versus a 50 ns q switched Nd YAG laser |
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