Phosphorylated Silk Fibroin Matrix for Methotrexate Release

Silk-based matrix was produced for delivery of a model anticancer drug, methotrexate (MTX). The calculation of net charge of silk fibroin and MTX was performed to better understand the electrostatic interactions during matrix formation upon casting. Silk fibroin films were cast at pH 7.2 and pH 3.5....

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Veröffentlicht in:	Molecular pharmaceutics 2015-01, Vol.12 (1), p.75-86
Hauptverfasser:	Volkov, Vadim, Sárria, Marisa P, Gomes, Andreia C, Cavaco-Paulo, Artur
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bombyx Cell Line, Tumor Cell Proliferation Cyclic AMP-Dependent Protein Kinases - chemistry Diffusion DLS Drug Delivery Systems Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - chemistry Enzymes - chemistry Fibroins - chemistry Hot Temperature Humans Hydrogen-Ion Concentration Light Methotrexate Methotrexate - administration & dosage Methotrexate - chemistry Net charge Phosphorylation Protein Structure, Secondary Scattering, Radiation Science & Technology Sericins - chemistry silk fibroin Silk ﬁbroin Static Electricity
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