Increased expression of fibroblast growth factor receptor 1 in endometriosis and its correlation with endometriosis-related dysmenorrhea and recurrence
Abstract Objective(s) This study aims to identify a critical molecule that potentially participates in endometriosis pathogenesis and characterize its correlation with dysmenorrhea and recurrence. Study design We utilized a bioinformatics-based strategy to screen for candidate genes and fibroblast g...
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| Veröffentlicht in: | European journal of obstetrics & gynecology and reproductive biology 2015-01, Vol.184, p.117-124 |
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| container_title | European journal of obstetrics & gynecology and reproductive biology |
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| creator | Zhao, Linjie Yang, Huiliang Xuan, Yu Luo, Zhongyue Lin, Qiao Zhao, Jitong Ren, Ning Zhou, Shengtao Zhao, Xia |
| description | Abstract Objective(s) This study aims to identify a critical molecule that potentially participates in endometriosis pathogenesis and characterize its correlation with dysmenorrhea and recurrence. Study design We utilized a bioinformatics-based strategy to screen for candidate genes and fibroblast growth factor receptor 1(FGFR1) was chosen for further validation. FGFR1 expression was examined in specimens of ectopic and eutopic endometrium obtained from 48 patients with endometriosis and specimens of eutopic endometrium from 26 healthy control subjects using immunohistochemistry and Western blotting. In addition, FGFR shRNA treatment was applied in a nude mice endometriosis model to examine the functional role of FGFR1 in endometriosis formation in vivo. Results FGFR1 was found commonly overexpressed in ectopic endometrium of endometriosis compared with either its eutopic counterpart or endometrium from normal patients ( P < 0.05). FGFR shRNA treatment impaired endometriosis formation and alleviated endometriosis-related symptoms in vivo . FGFR1 expression in ectopic endometrium was correlated with dysmenorrhea severity ( P < 0.05) and recurrence in endometriosis patients ( P < 0.05). Conclusion(s) FGFR1 might be involved in endometriosis development, which could possibly serve as a novel therapeutic target and prognostic marker for this disease. |
| doi_str_mv | 10.1016/j.ejogrb.2014.11.013 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1642608330</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S030121151400596X</els_id><sourcerecordid>1642608330</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-bc61951b43b76e0c40d8c8f8fc41b85030c637508badc6542bb82de70a5a07843</originalsourceid><addsrcrecordid>eNqFUk1v1TAQtBAVfRT-AUI-cknwxnGSd0FCFdBKlTi0lbhZ_ti0Don9sJOW90v4u3X6ChJc8MWWdmZ2PbOEvAFWAoPm_VDiEG6iLisGdQlQMuDPyAa6tiraRtTPyYZxBkUFII7Jy5QGlg_n2xfkuBKCMcHFhvw69yaiSmgp_txFTMkFT0NPe6dj0KNKM72J4X6-pb0yc4g0osHd-gDqPEVvw4RzdCG5RJW31M2JmhAjjmpete5d5v4FKx5ruaPdpwl9xt6ieuRm7SUzvcFX5KhXY8LXT_cJuf786er0rLj4-uX89ONFYWpo50KbBrYCdM112yAzNbOd6fquz2XdiWyAaXgrWKeVNdmUSuuustgyJRRru5qfkHcH3V0MPxZMs5xcMjiOymNYkoSmrhrWcc4ytD5ATQwpRezlLrpJxb0EJtdI5CAPkcg1EgkgcySZ9vapw6IntH9IvzPIgA8HAOZ_3jmMMhm3emBd9mOWNrj_dfhXwIzOO6PG77jHNIQl-uyhBJkqyeTluhbrVkCdB9g23_gD0CS3oQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1642608330</pqid></control><display><type>article</type><title>Increased expression of fibroblast growth factor receptor 1 in endometriosis and its correlation with endometriosis-related dysmenorrhea and recurrence</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Zhao, Linjie ; Yang, Huiliang ; Xuan, Yu ; Luo, Zhongyue ; Lin, Qiao ; Zhao, Jitong ; Ren, Ning ; Zhou, Shengtao ; Zhao, Xia</creator><creatorcontrib>Zhao, Linjie ; Yang, Huiliang ; Xuan, Yu ; Luo, Zhongyue ; Lin, Qiao ; Zhao, Jitong ; Ren, Ning ; Zhou, Shengtao ; Zhao, Xia</creatorcontrib><description>Abstract Objective(s) This study aims to identify a critical molecule that potentially participates in endometriosis pathogenesis and characterize its correlation with dysmenorrhea and recurrence. Study design We utilized a bioinformatics-based strategy to screen for candidate genes and fibroblast growth factor receptor 1(FGFR1) was chosen for further validation. FGFR1 expression was examined in specimens of ectopic and eutopic endometrium obtained from 48 patients with endometriosis and specimens of eutopic endometrium from 26 healthy control subjects using immunohistochemistry and Western blotting. In addition, FGFR shRNA treatment was applied in a nude mice endometriosis model to examine the functional role of FGFR1 in endometriosis formation in vivo. Results FGFR1 was found commonly overexpressed in ectopic endometrium of endometriosis compared with either its eutopic counterpart or endometrium from normal patients ( P < 0.05). FGFR shRNA treatment impaired endometriosis formation and alleviated endometriosis-related symptoms in vivo . FGFR1 expression in ectopic endometrium was correlated with dysmenorrhea severity ( P < 0.05) and recurrence in endometriosis patients ( P < 0.05). Conclusion(s) FGFR1 might be involved in endometriosis development, which could possibly serve as a novel therapeutic target and prognostic marker for this disease.</description><identifier>ISSN: 0301-2115</identifier><identifier>EISSN: 1872-7654</identifier><identifier>DOI: 10.1016/j.ejogrb.2014.11.013</identifier><identifier>PMID: 25500535</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Animals ; Computational Biology ; Disease Models, Animal ; Dysmenorrhea ; Dysmenorrhea - etiology ; Dysmenorrhea - genetics ; Dysmenorrhea - metabolism ; Dysmenorrhea - pathology ; Endometriosis ; Endometriosis - complications ; Endometriosis - genetics ; Endometriosis - metabolism ; Endometriosis - pathology ; Endometrium - metabolism ; Endometrium - pathology ; Female ; FGFR1 ; Gene Expression Profiling ; Humans ; Mice ; Mice, Nude ; Obstetrics and Gynecology ; Receptor, Fibroblast Growth Factor, Type 1 - genetics ; Receptor, Fibroblast Growth Factor, Type 1 - metabolism ; Recurrence</subject><ispartof>European journal of obstetrics & gynecology and reproductive biology, 2015-01, Vol.184, p.117-124</ispartof><rights>2014</rights><rights>Copyright © 2014. Published by Elsevier Ireland Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-bc61951b43b76e0c40d8c8f8fc41b85030c637508badc6542bb82de70a5a07843</citedby><cites>FETCH-LOGICAL-c417t-bc61951b43b76e0c40d8c8f8fc41b85030c637508badc6542bb82de70a5a07843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S030121151400596X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25500535$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Linjie</creatorcontrib><creatorcontrib>Yang, Huiliang</creatorcontrib><creatorcontrib>Xuan, Yu</creatorcontrib><creatorcontrib>Luo, Zhongyue</creatorcontrib><creatorcontrib>Lin, Qiao</creatorcontrib><creatorcontrib>Zhao, Jitong</creatorcontrib><creatorcontrib>Ren, Ning</creatorcontrib><creatorcontrib>Zhou, Shengtao</creatorcontrib><creatorcontrib>Zhao, Xia</creatorcontrib><title>Increased expression of fibroblast growth factor receptor 1 in endometriosis and its correlation with endometriosis-related dysmenorrhea and recurrence</title><title>European journal of obstetrics & gynecology and reproductive biology</title><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><description>Abstract Objective(s) This study aims to identify a critical molecule that potentially participates in endometriosis pathogenesis and characterize its correlation with dysmenorrhea and recurrence. Study design We utilized a bioinformatics-based strategy to screen for candidate genes and fibroblast growth factor receptor 1(FGFR1) was chosen for further validation. FGFR1 expression was examined in specimens of ectopic and eutopic endometrium obtained from 48 patients with endometriosis and specimens of eutopic endometrium from 26 healthy control subjects using immunohistochemistry and Western blotting. In addition, FGFR shRNA treatment was applied in a nude mice endometriosis model to examine the functional role of FGFR1 in endometriosis formation in vivo. Results FGFR1 was found commonly overexpressed in ectopic endometrium of endometriosis compared with either its eutopic counterpart or endometrium from normal patients ( P < 0.05). FGFR shRNA treatment impaired endometriosis formation and alleviated endometriosis-related symptoms in vivo . FGFR1 expression in ectopic endometrium was correlated with dysmenorrhea severity ( P < 0.05) and recurrence in endometriosis patients ( P < 0.05). Conclusion(s) FGFR1 might be involved in endometriosis development, which could possibly serve as a novel therapeutic target and prognostic marker for this disease.</description><subject>Animals</subject><subject>Computational Biology</subject><subject>Disease Models, Animal</subject><subject>Dysmenorrhea</subject><subject>Dysmenorrhea - etiology</subject><subject>Dysmenorrhea - genetics</subject><subject>Dysmenorrhea - metabolism</subject><subject>Dysmenorrhea - pathology</subject><subject>Endometriosis</subject><subject>Endometriosis - complications</subject><subject>Endometriosis - genetics</subject><subject>Endometriosis - metabolism</subject><subject>Endometriosis - pathology</subject><subject>Endometrium - metabolism</subject><subject>Endometrium - pathology</subject><subject>Female</subject><subject>FGFR1</subject><subject>Gene Expression Profiling</subject><subject>Humans</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Obstetrics and Gynecology</subject><subject>Receptor, Fibroblast Growth Factor, Type 1 - genetics</subject><subject>Receptor, Fibroblast Growth Factor, Type 1 - metabolism</subject><subject>Recurrence</subject><issn>0301-2115</issn><issn>1872-7654</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUk1v1TAQtBAVfRT-AUI-cknwxnGSd0FCFdBKlTi0lbhZ_ti0Don9sJOW90v4u3X6ChJc8MWWdmZ2PbOEvAFWAoPm_VDiEG6iLisGdQlQMuDPyAa6tiraRtTPyYZxBkUFII7Jy5QGlg_n2xfkuBKCMcHFhvw69yaiSmgp_txFTMkFT0NPe6dj0KNKM72J4X6-pb0yc4g0osHd-gDqPEVvw4RzdCG5RJW31M2JmhAjjmpete5d5v4FKx5ruaPdpwl9xt6ieuRm7SUzvcFX5KhXY8LXT_cJuf786er0rLj4-uX89ONFYWpo50KbBrYCdM112yAzNbOd6fquz2XdiWyAaXgrWKeVNdmUSuuustgyJRRru5qfkHcH3V0MPxZMs5xcMjiOymNYkoSmrhrWcc4ytD5ATQwpRezlLrpJxb0EJtdI5CAPkcg1EgkgcySZ9vapw6IntH9IvzPIgA8HAOZ_3jmMMhm3emBd9mOWNrj_dfhXwIzOO6PG77jHNIQl-uyhBJkqyeTluhbrVkCdB9g23_gD0CS3oQ</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Zhao, Linjie</creator><creator>Yang, Huiliang</creator><creator>Xuan, Yu</creator><creator>Luo, Zhongyue</creator><creator>Lin, Qiao</creator><creator>Zhao, Jitong</creator><creator>Ren, Ning</creator><creator>Zhou, Shengtao</creator><creator>Zhao, Xia</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150101</creationdate><title>Increased expression of fibroblast growth factor receptor 1 in endometriosis and its correlation with endometriosis-related dysmenorrhea and recurrence</title><author>Zhao, Linjie ; Yang, Huiliang ; Xuan, Yu ; Luo, Zhongyue ; Lin, Qiao ; Zhao, Jitong ; Ren, Ning ; Zhou, Shengtao ; Zhao, Xia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-bc61951b43b76e0c40d8c8f8fc41b85030c637508badc6542bb82de70a5a07843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Computational Biology</topic><topic>Disease Models, Animal</topic><topic>Dysmenorrhea</topic><topic>Dysmenorrhea - etiology</topic><topic>Dysmenorrhea - genetics</topic><topic>Dysmenorrhea - metabolism</topic><topic>Dysmenorrhea - pathology</topic><topic>Endometriosis</topic><topic>Endometriosis - complications</topic><topic>Endometriosis - genetics</topic><topic>Endometriosis - metabolism</topic><topic>Endometriosis - pathology</topic><topic>Endometrium - metabolism</topic><topic>Endometrium - pathology</topic><topic>Female</topic><topic>FGFR1</topic><topic>Gene Expression Profiling</topic><topic>Humans</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Obstetrics and Gynecology</topic><topic>Receptor, Fibroblast Growth Factor, Type 1 - genetics</topic><topic>Receptor, Fibroblast Growth Factor, Type 1 - metabolism</topic><topic>Recurrence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Linjie</creatorcontrib><creatorcontrib>Yang, Huiliang</creatorcontrib><creatorcontrib>Xuan, Yu</creatorcontrib><creatorcontrib>Luo, Zhongyue</creatorcontrib><creatorcontrib>Lin, Qiao</creatorcontrib><creatorcontrib>Zhao, Jitong</creatorcontrib><creatorcontrib>Ren, Ning</creatorcontrib><creatorcontrib>Zhou, Shengtao</creatorcontrib><creatorcontrib>Zhao, Xia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Linjie</au><au>Yang, Huiliang</au><au>Xuan, Yu</au><au>Luo, Zhongyue</au><au>Lin, Qiao</au><au>Zhao, Jitong</au><au>Ren, Ning</au><au>Zhou, Shengtao</au><au>Zhao, Xia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased expression of fibroblast growth factor receptor 1 in endometriosis and its correlation with endometriosis-related dysmenorrhea and recurrence</atitle><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>184</volume><spage>117</spage><epage>124</epage><pages>117-124</pages><issn>0301-2115</issn><eissn>1872-7654</eissn><abstract>Abstract Objective(s) This study aims to identify a critical molecule that potentially participates in endometriosis pathogenesis and characterize its correlation with dysmenorrhea and recurrence. Study design We utilized a bioinformatics-based strategy to screen for candidate genes and fibroblast growth factor receptor 1(FGFR1) was chosen for further validation. FGFR1 expression was examined in specimens of ectopic and eutopic endometrium obtained from 48 patients with endometriosis and specimens of eutopic endometrium from 26 healthy control subjects using immunohistochemistry and Western blotting. In addition, FGFR shRNA treatment was applied in a nude mice endometriosis model to examine the functional role of FGFR1 in endometriosis formation in vivo. Results FGFR1 was found commonly overexpressed in ectopic endometrium of endometriosis compared with either its eutopic counterpart or endometrium from normal patients ( P < 0.05). FGFR shRNA treatment impaired endometriosis formation and alleviated endometriosis-related symptoms in vivo . FGFR1 expression in ectopic endometrium was correlated with dysmenorrhea severity ( P < 0.05) and recurrence in endometriosis patients ( P < 0.05). Conclusion(s) FGFR1 might be involved in endometriosis development, which could possibly serve as a novel therapeutic target and prognostic marker for this disease.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>25500535</pmid><doi>10.1016/j.ejogrb.2014.11.013</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Computational Biology Disease Models, Animal Dysmenorrhea Dysmenorrhea - etiology Dysmenorrhea - genetics Dysmenorrhea - metabolism Dysmenorrhea - pathology Endometriosis Endometriosis - complications Endometriosis - genetics Endometriosis - metabolism Endometriosis - pathology Endometrium - metabolism Endometrium - pathology Female FGFR1 Gene Expression Profiling Humans Mice Mice, Nude Obstetrics and Gynecology Receptor, Fibroblast Growth Factor, Type 1 - genetics Receptor, Fibroblast Growth Factor, Type 1 - metabolism Recurrence |
| title | Increased expression of fibroblast growth factor receptor 1 in endometriosis and its correlation with endometriosis-related dysmenorrhea and recurrence |
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