Nonopsonic and Opsonic Association of Mycobacterium tuberculosis with Resident Alveolar Macrophages Is Inefficient

The association of Mycobacterium tuberculosis with alveolar macrophages (Mphi) in a serum-free environment is a crucial first step in the pathogenesis of this facultative intracellular pathogen. We present data demonstrating that freshly explanted alveolar Mphi do not efficiently bind M. tuberculosi...

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Veröffentlicht in:	The Journal of immunology (1950) 1998-06, Vol.160 (11), p.5514-5521
Hauptverfasser:	Stokes, Richard W, Thorson, Lisa M, Speert, David P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - metabolism Antigen-Antibody Reactions Blood - microbiology Cattle Cell Adhesion - drug effects Cell Adhesion - immunology Complement C3b - metabolism Erythrocytes - immunology Female Immunoglobulin G - blood Immunoglobulin M - blood Ligands Lymphocyte Function-Associated Antigen-1 - metabolism Macrophages, Alveolar - immunology Macrophages, Alveolar - metabolism Macrophages, Alveolar - microbiology Macrophages, Peritoneal - immunology Macrophages, Peritoneal - metabolism Macrophages, Peritoneal - microbiology Mice Mice, Inbred BALB C Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - metabolism Opsonin Proteins - blood Proteolipids - pharmacology Pulmonary Surfactant-Associated Proteins Pulmonary Surfactants - pharmacology Receptors, Complement - metabolism Tetradecanoylphorbol Acetate - pharmacology Zymosan - metabolism
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