Pyrimethamine Impairs Host Resistance to Infection with Listeria monocytogenes in BALB/c Mice

Increased mortality has been observed when HTV-infected patients were treated with pyrimethamine (Pyr) as prophylaxis for toxoplasmic encephalitis, suggesting that Pyr might possess im-munosuppressive activity. To analyze this in an animal model, immune function was assessed in BALB/c mice using a b...

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Veröffentlicht in:	Toxicological sciences 1998-04, Vol.42 (2), p.91-98
Hauptverfasser:	Freund, Yvonne R., Riccio, Edward S., Phillips, Sandra J., Dousman, Linda, MacGregor, James T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Disease Susceptibility - immunology Dose-Response Relationship, Drug Drug toxicity and drugs side effects treatment Female Listeria monocytogenes - isolation & purification Listeriosis - immunology Listeriosis - mortality Liver - microbiology Lymphocyte Subsets Medical sciences Mice Mice, Inbred BALB C Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Pyrimethamine - toxicity Spleen - microbiology
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