The molecular basis of the human serum paraoxonase activity polymorphism

The organophosphate cholinesterase inhibitor paraoxon is hydrolysed by serum paraoxonase/arylesterase. A genetic polymorphism of paraoxonase (PON) activity which determines high versus low paraoxon hydrolysis in human populations, may determine sensitivity to parathion poisoning. We demonstrate that...

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Veröffentlicht in:	Nature genetics 1993-01, Vol.3 (1), p.73-76
Hauptverfasser:	Humbert, Richard, Adler, David A., Disteche, Christine M., Hassett, Christopher, Omiecinski, Curtis J., Furlong, Clement E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Aryldialkylphosphatase arylesterase Base Sequence Biomedical and Life Sciences Biomedicine Cancer Research chromosome 7 Chromosomes, Human, Pair 7 Cloning, Molecular DNA Gene Function Human Genetics Humans man mapping Molecular Sequence Data Paraoxon Phosphoric Monoester Hydrolases - blood Phosphoric Monoester Hydrolases - genetics Polymorphism, Restriction Fragment Length restriction fragment length polymorphism
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