Development of a folate-modified curcumin loaded micelle delivery system for cancer targeting

The Cur-FPPs’ preparing flow chart and cellular uptake on MCF-7 and HepG2 cells in vitro. •The folate-modified Curcumin loaded micelles (Cur-FPPs) were prepared by thin-film hydration method.•The Cur-FPPs increased the cytotoxicity and cellular uptake of Cur on MCF-7 and HepG2 cells in vitro.•The Cu...

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Veröffentlicht in:	Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2014-09, Vol.121, p.206-213
Hauptverfasser:	Yang, Chunfen, Chen, Hao, Zhao, Jie, Pang, Xin, Xi, Yanwei, Zhai, Guangxi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer Cell Death - drug effects Cell Survival - drug effects Cellular Charge coupled devices Curcumin Curcumin - administration & dosage Curcumin - pharmacokinetics Curcumin - pharmacology Curcumin - therapeutic use Delivery systems Drug Delivery Systems Endocytosis - drug effects Folate Folic Acid - chemistry Formulations Hemolysis - drug effects Hep G2 Cells Humans In vitro testing Irritants - pharmacology Lactic Acid - chemical synthesis Lactic Acid - chemistry Male MCF-7 Cells Micelles Microscopy, Fluorescence mPEG-PLA Nanostructure Neoplasms - drug therapy Particle Size Polyesters Polyethylene Glycols - chemical synthesis Polyethylene Glycols - chemistry Polymers - chemical synthesis Polymers - chemistry Rabbits Rats Static Electricity Surface-Active Agents - chemical synthesis Surface-Active Agents - chemistry
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