Review of approaches to the recording of background lesions in toxicologic pathology studies in rats
Pathological evaluation of lesions caused directly by xenobiotic treatment must always take into account the recognition of background (incidental) findings. Background lesions can be congenital or hereditary, histological variations, changes related to trauma or normal aging and physiologic or horm...
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| Veröffentlicht in: | Toxicology letters 2014-08, Vol.229 (1), p.134-143 |
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| container_title | Toxicology letters |
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| creator | McInnes, E.F. Scudamore, C.L. |
| description | Pathological evaluation of lesions caused directly by xenobiotic treatment must always take into account the recognition of background (incidental) findings. Background lesions can be congenital or hereditary, histological variations, changes related to trauma or normal aging and physiologic or hormonal changes. This review focuses on the importance and correct approach to recording of background changes and includes discussion on sources of variability in background changes, the correct use of terminology, the concept of thresholds, historical control data, diagnostic drift, blind reading of slides, scoring and artifacts. The review is illustrated with background lesions in Sprague Dawley and Wistar rats. |
| doi_str_mv | 10.1016/j.toxlet.2014.06.005 |
| format | Article |
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Background lesions can be congenital or hereditary, histological variations, changes related to trauma or normal aging and physiologic or hormonal changes. This review focuses on the importance and correct approach to recording of background changes and includes discussion on sources of variability in background changes, the correct use of terminology, the concept of thresholds, historical control data, diagnostic drift, blind reading of slides, scoring and artifacts. 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| fulltext | fulltext |
| identifier | ISSN: 0378-4274 |
| ispartof | Toxicology letters, 2014-08, Vol.229 (1), p.134-143 |
| issn | 0378-4274 1879-3169 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1642272485 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Aging - pathology Animals Background lesions Blind reading Blinds Congenital Abnormalities - pathology Diagnostic drift Diagnostic systems Diet Historical control data Housing, Animal Infections - pathology Lesions Pathology Pathology - methods Rat Rats Rats - physiology Rats, Sprague-Dawley Rats, Wistar Recording Reference Values Reproduction Scoring Sexual Maturation Stress, Psychological - pathology Terminology Terminology as Topic Toxicology - methods Wounds and Injuries - pathology |
| title | Review of approaches to the recording of background lesions in toxicologic pathology studies in rats |
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