Infection in Organ-Transplant Recipients
A primary goal in organ transplantation is the prevention or effective treatment of infection, the most common life-threatening complication of long-term immunosuppressive therapy. The challenges involved in achieving this goal are several: a broad range of potential sources of infection ranging fro...
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| Veröffentlicht in: | The New England journal of medicine 1998-06, Vol.338 (24), p.1741-1751 |
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| container_end_page | 1751 |
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| container_issue | 24 |
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| container_title | The New England journal of medicine |
| container_volume | 338 |
| creator | Fishman, Jay A Rubin, Robert H |
| description | A primary goal in organ transplantation is the prevention or effective treatment of infection, the most common life-threatening complication of long-term immunosuppressive therapy. The challenges involved in achieving this goal are several: a broad range of potential sources of infection ranging from latent viruses to pathogens of both community and hospital origin; immunosuppression-induced impairment of the inflammatory response, which attenuates the signs and symptoms of invasive infection; and the adverse effects of the antimicrobial drugs used for prophylaxis and therapy, which result both from the duration of therapy required and from interactions with the immunosuppressive drugs cyclosporine and tacrolimus. Our . . . |
| doi_str_mv | 10.1056/NEJM199806113382407 |
| format | Article |
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The challenges involved in achieving this goal are several: a broad range of potential sources of infection ranging from latent viruses to pathogens of both community and hospital origin; immunosuppression-induced impairment of the inflammatory response, which attenuates the signs and symptoms of invasive infection; and the adverse effects of the antimicrobial drugs used for prophylaxis and therapy, which result both from the duration of therapy required and from interactions with the immunosuppressive drugs cyclosporine and tacrolimus. 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The challenges involved in achieving this goal are several: a broad range of potential sources of infection ranging from latent viruses to pathogens of both community and hospital origin; immunosuppression-induced impairment of the inflammatory response, which attenuates the signs and symptoms of invasive infection; and the adverse effects of the antimicrobial drugs used for prophylaxis and therapy, which result both from the duration of therapy required and from interactions with the immunosuppressive drugs cyclosporine and tacrolimus. 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| ispartof | The New England journal of medicine, 1998-06, Vol.338 (24), p.1741-1751 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Anti-Infective Agents - adverse effects Anti-Infective Agents - therapeutic use Biological and medical sciences Cytomegalovirus Cytomegalovirus Infections - prevention & control Diagnosis, Differential Fever - etiology Humans Immunosuppression Infection - etiology Infection - therapy Medical sciences Miscellaneous Organ Transplantation Postoperative Complications - drug therapy Postoperative Complications - etiology Postoperative Complications - prevention & control Risk Factors Staphylococcus infections Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Time Factors Transplants & implants Tuberculosis Viruses |
| title | Infection in Organ-Transplant Recipients |
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