Versatile hybrid polyethyleneimine–mesoporous carbon nanoparticles for targeted delivery
To meet the needs of targeted drug delivery and medical imaging, uniform mesoporous carbon spheres (UMCS) were functionalized using hyperbranched polyethyleneimine (PEI) covalently linked with fluorescein isothiocyanate (FITC) and folic acid (FA). Folate-receptor-positive KB cancer cells internalize...
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| Veröffentlicht in: | Carbon (New York) 2014-11, Vol.79, p.123-134 |
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| creator | Wan, Long Zhao, Qinfu Zhao, Peng He, Bing Jiang, Tongying Zhang, Qiang Wang, Siling |
| description | To meet the needs of targeted drug delivery and medical imaging, uniform mesoporous carbon spheres (UMCS) were functionalized using hyperbranched polyethyleneimine (PEI) covalently linked with fluorescein isothiocyanate (FITC) and folic acid (FA). Folate-receptor-positive KB cancer cells internalized five times more nanoparticles than A549 cells deficient in folate receptors in vitro using flow cytometry and confocal microscopy. The in vivo distribution results also confirmed that the FA–PEI–FITC–UMCS nanoparticles could target the FA-positive tumors. In addition, the specifically targeted hybrid carbon nanoparticles exhibited non-cytotoxic and controlled intracellular release (pH dependent) of the loaded agents. The in vivo antitumor effect of the paclitaxel (PTX)-loaded nanoparticles was investigated in Kunming mice harboring a hepatic H22 tumor. PTX-loaded FA–PEI–UMCS nanoparticles displayed superior antitumor effects compared to other PTX formulations, and the tumor growth inhibition rate was 86.53% compared with the control group (saline) for the enhanced targeted accumulation of NPs in tumor cells. |
| doi_str_mv | 10.1016/j.carbon.2014.07.050 |
| format | Article |
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Folate-receptor-positive KB cancer cells internalized five times more nanoparticles than A549 cells deficient in folate receptors in vitro using flow cytometry and confocal microscopy. The in vivo distribution results also confirmed that the FA–PEI–FITC–UMCS nanoparticles could target the FA-positive tumors. In addition, the specifically targeted hybrid carbon nanoparticles exhibited non-cytotoxic and controlled intracellular release (pH dependent) of the loaded agents. The in vivo antitumor effect of the paclitaxel (PTX)-loaded nanoparticles was investigated in Kunming mice harboring a hepatic H22 tumor. 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Folate-receptor-positive KB cancer cells internalized five times more nanoparticles than A549 cells deficient in folate receptors in vitro using flow cytometry and confocal microscopy. The in vivo distribution results also confirmed that the FA–PEI–FITC–UMCS nanoparticles could target the FA-positive tumors. In addition, the specifically targeted hybrid carbon nanoparticles exhibited non-cytotoxic and controlled intracellular release (pH dependent) of the loaded agents. The in vivo antitumor effect of the paclitaxel (PTX)-loaded nanoparticles was investigated in Kunming mice harboring a hepatic H22 tumor. PTX-loaded FA–PEI–UMCS nanoparticles displayed superior antitumor effects compared to other PTX formulations, and the tumor growth inhibition rate was 86.53% compared with the control group (saline) for the enhanced targeted accumulation of NPs in tumor cells.</description><subject>Biomedical materials</subject><subject>Carbon</subject><subject>Chemistry</subject><subject>Colloidal state and disperse state</subject><subject>Cross-disciplinary physics: materials science; rheology</subject><subject>Exact sciences and technology</subject><subject>General and physical chemistry</subject><subject>In vivo testing</subject><subject>In vivo tests</subject><subject>Materials science</subject><subject>Nanoparticles</subject><subject>Nanopowders</subject><subject>Nanoscale materials and structures: fabrication and characterization</subject><subject>Physical and chemical studies. Granulometry. 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| source | Elsevier ScienceDirect Journals Complete |
| subjects | Biomedical materials Carbon Chemistry Colloidal state and disperse state Cross-disciplinary physics: materials science rheology Exact sciences and technology General and physical chemistry In vivo testing In vivo tests Materials science Nanoparticles Nanopowders Nanoscale materials and structures: fabrication and characterization Physical and chemical studies. Granulometry. Electrokinetic phenomena Physics Porous materials Reagents Surgical implants Tumors |
| title | Versatile hybrid polyethyleneimine–mesoporous carbon nanoparticles for targeted delivery |
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