An aptamer ligand based liposomal nanocarrier system that targets tumor endothelial cells

Abstract The objective of this study was to construct our recently developed aptamer-modified targeted liposome nano-carrier (Apt-PEG-LPs) system to target primary cultured m ouse t umor e ndothelial c ells (mTEC), both in vitro and in vivo . We first synthesized an aptamer-polyethylene glycol 2000-...

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Veröffentlicht in:	Biomaterials 2014-08, Vol.35 (25), p.7110-7120
Hauptverfasser:	Ara, Mst. Naznin, Matsuda, Takashi, Hyodo, Mamoru, Sakurai, Yu, Hatakeyama, Hiroto, Ohga, Noritaka, Hida, Kyoko, Harashima, Hideyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Aptamer-liposomes Aptamers, Nucleotide - chemistry Biocompatibility Biomedical materials Cell Line, Tumor Cells, Cultured Dentistry Drug Carriers - chemistry Drug Delivery Systems - methods Endocytosis Endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism Humans In vivo testing In vivo tests Intracellular uptake Ligands Liposomes - chemistry Mice Microscopy, Confocal Nanostructure Nanostructures - chemistry Phosphatidylethanolamines - chemistry Polyethylene Glycols - chemistry Surgical implants Targeted delivery Tumor endothelial cells Tumors
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