Lactoferrin-modified PEG-co-PCL nanoparticles for enhanced brain delivery of NAP peptide following intranasal administration

Abstract Development of effective non-invasive drug delivery systems is of great importance to the treatment of Alzheimer's diseases and has made great progress in recent years. In this work, lactoferrin (Lf), a natural iron binding protein, whose receptor is highly expressed in both respirator...

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Veröffentlicht in:	Biomaterials 2013-05, Vol.34 (15), p.3870-3881
Hauptverfasser:	Liu, Zhongyang, Jiang, Mengyin, Kang, Ting, Miao, Deyu, Gu, Guangzhi, Song, Qingxiang, Yao, Lei, Hu, Quanyin, Tu, Yifan, Pang, Zhiqing, Chen, Hongzhuan, Jiang, Xinguo, Gao, Xiaoling, Chen, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - metabolism Administration, Intranasal Advanced Basic Science Alzheimer's disease Amino Acid Sequence Amyloid beta-Peptides - administration & dosage Amyloid beta-Peptides - toxicity Animals Brain Brain - drug effects Brain - enzymology Brain - metabolism Brain - pathology Brain targeting Carbocyanines - metabolism Cell Line Choline O-Acetyltransferase - metabolism Coumarins - blood Coumarins - pharmacokinetics Coumarins - pharmacology Dentistry Drug Delivery Systems Endocytosis - drug effects Hippocampus Humans Ibotenic Acid - pharmacology Intranasal administration Lactoferrin Lactoferrin - metabolism Male Mice Mice, Inbred ICR Molecular Sequence Data Nanoparticle Nanoparticles Nanoparticles - chemistry Nanoparticles - ultrastructure NAP Neuroprotective Agents - administration & dosage Neuroprotective Agents - chemistry Neuroprotective Agents - pharmacology Peptides Peptides - administration & dosage Peptides - chemistry Peptides - pharmacology Polyesters - chemistry Polyethylene Glycols - chemistry Proteins Rats, Sprague-Dawley Thiazoles - blood Thiazoles - pharmacokinetics Thiazoles - pharmacology Tissue Distribution - drug effects X-ray photoelectron spectroscopy
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