An Improved Synthesis of Imidazo[4,5-b]pyridines and Imidazo[4,5-b]pyrazines by Palladium Catalyzed Amidation using Xantphos in a 1,4-Dioxane:tert-Amyl Alcohol Solvent System
Herein an improved protocol for the synthesis of imidazo[4,5‐b]pyridines and imidazo[4,5‐b]pyrazines using a palladium‐catalyzed amidation that utilizes Xantphos as an ancillary phosphine ligand is reported. The use of a binary solvent system comprised of 1,4‐dioxane and tert‐amyl alcohol was crucia...
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| Veröffentlicht in: | Advanced synthesis & catalysis 2014-11, Vol.356 (16), p.3465-3470 |
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| container_end_page | 3470 |
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| container_issue | 16 |
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| container_title | Advanced synthesis & catalysis |
| container_volume | 356 |
| creator | Rosenberg, Adam J. Ahmed, Ijaz Wilson, Robert J. Williams, Theresa M. Kaminsky, Lauren Clark, Daniel A. |
| description | Herein an improved protocol for the synthesis of imidazo[4,5‐b]pyridines and imidazo[4,5‐b]pyrazines using a palladium‐catalyzed amidation that utilizes Xantphos as an ancillary phosphine ligand is reported. The use of a binary solvent system comprised of 1,4‐dioxane and tert‐amyl alcohol was crucial in eliminating unwanted by‐products. |
| doi_str_mv | 10.1002/adsc.201400465 |
| format | Article |
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| ispartof | Advanced synthesis & catalysis, 2014-11, Vol.356 (16), p.3465-3470 |
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| source | Wiley Journals |
| subjects | Alcohols Byproducts Catalysis Ligands nitrogen heterocycles P ligands Palladium Phosphines Solvents Synthesis |
| title | An Improved Synthesis of Imidazo[4,5-b]pyridines and Imidazo[4,5-b]pyrazines by Palladium Catalyzed Amidation using Xantphos in a 1,4-Dioxane:tert-Amyl Alcohol Solvent System |
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