Direct cytosolic siRNA delivery by reconstituted high density lipoprotein for target-specific therapy of tumor angiogenesis

Abstract We described here the mechanisms by which small interfering RNA (siRNA) molecules incorporated in reconstituted high density lipoprotein (rHDL) were efficiently transferred into the cytoplasm of cells to perform target-specific therapy of tumor angiogenesis. Using fluorescent-tagged apolipo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biomaterials 2014-08, Vol.35 (25), p.7214-7227
Hauptverfasser:	Ding, Yang, Wang, Yazhe, Zhou, Jianping, Gu, Xiaochen, Wang, Wei, Liu, Congyan, Bao, Xiuli, Wang, Cheng, Li, Yuanru, Zhang, Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Angiogenesis Inhibitors - chemistry Angiogenesis Inhibitors - pharmacology Animals Anti-angiogenic therapy Apolipoprotein A-I - chemistry Breast Cholesterol - chemistry Cholesterol - pharmacology Cholesterol-conjugated siRNA Cytosol - drug effects Cytosol - metabolism Dentistry Direct cytosolic delivery Down-Regulation Drug Delivery Systems - methods Female Guinea Pigs Hep G2 Cells High density Humans Lipoproteins Male MCF-7 Cells Mice Mice, Nude Nanoparticles Nanoparticles - chemistry Neovascularization, Pathologic - drug therapy Reconstituted high density lipoprotein Ribonucleic acids RNA Interference RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - chemistry RNA, Small Interfering - pharmacology Strontium Therapy Tumor-selective accumulation Tumors Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!