Chronic exposure to pentachlorophenol alters thyroid hormones and thyroid hormone pathway mRNAs in zebrafish
Pentachlorophenol (PCP) is frequently detected in the aquatic environment and has been implicated as an endocrine disruptor in fish. In the present study, 4‐month‐old zebrafish (Danio rerio) were exposed to 1 of 4 concentrations of PCP (0.1, 1, 9, and 27 µg/L) for 70 d. The effects of PCP exposure o...
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| Veröffentlicht in: | Environmental toxicology and chemistry 2014-01, Vol.33 (1), p.170-176 |
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| creator | Yu, Li‐Qin Zhao, Gao‐Feng Feng, Min Wen, Wu Li, Kun Zhang, Pan‐Wei Peng, Xi Huo, Wei‐Jie Zhou, Huai‐Dong |
| description | Pentachlorophenol (PCP) is frequently detected in the aquatic environment and has been implicated as an endocrine disruptor in fish. In the present study, 4‐month‐old zebrafish (Danio rerio) were exposed to 1 of 4 concentrations of PCP (0.1, 1, 9, and 27 µg/L) for 70 d. The effects of PCP exposure on plasma thyroid hormone levels, and the expression levels of selected genes, were measured in the brain and liver. The PCP exposure at 27 µg/L resulted in elevated plasma thyroxine concentrations in male and female zebrafish and depressed 3, 5, 3'‐triiodothyronine concentrations in males only. In both sexes, PCP exposure resulted in decreased messenger RNA (mRNA) expression levels of thyroid‐stimulating hormone β‐subunit (tshβ) and thyroid hormone receptor β (trβ) in the brain, as well as increased liver levels of uridine diphosphoglucuronosyl transferase (ugt1ab) and decreased deiodinase 1 (dio1). The authors also identified several sex‐specific effects of PCP exposure, including changes in mRNA levels for deiodinase 2 (dio2), cytosolic sulfotransferase (sult1 st5), and transthyretin (ttr) genes in the liver. Environmental PCP exposure also caused an increased malformation rate in offspring that received maternal exposure to PCP. The present study demonstrates that chronic exposure to environmental levels of PCP alters plasma thyroid hormone levels, as well as the expression of genes associated with thyroid hormone signaling and metabolism in the hypothalamic‐pituitary‐thyroid (HPT) axis and liver, resulting in abnormal zebrafish development. Environ Toxicol Chem 2014;33:170–176. © 2013 SETAC |
| doi_str_mv | 10.1002/etc.2408 |
| format | Article |
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In the present study, 4‐month‐old zebrafish (Danio rerio) were exposed to 1 of 4 concentrations of PCP (0.1, 1, 9, and 27 µg/L) for 70 d. The effects of PCP exposure on plasma thyroid hormone levels, and the expression levels of selected genes, were measured in the brain and liver. The PCP exposure at 27 µg/L resulted in elevated plasma thyroxine concentrations in male and female zebrafish and depressed 3, 5, 3'‐triiodothyronine concentrations in males only. In both sexes, PCP exposure resulted in decreased messenger RNA (mRNA) expression levels of thyroid‐stimulating hormone β‐subunit (tshβ) and thyroid hormone receptor β (trβ) in the brain, as well as increased liver levels of uridine diphosphoglucuronosyl transferase (ugt1ab) and decreased deiodinase 1 (dio1). The authors also identified several sex‐specific effects of PCP exposure, including changes in mRNA levels for deiodinase 2 (dio2), cytosolic sulfotransferase (sult1 st5), and transthyretin (ttr) genes in the liver. Environmental PCP exposure also caused an increased malformation rate in offspring that received maternal exposure to PCP. The present study demonstrates that chronic exposure to environmental levels of PCP alters plasma thyroid hormone levels, as well as the expression of genes associated with thyroid hormone signaling and metabolism in the hypothalamic‐pituitary‐thyroid (HPT) axis and liver, resulting in abnormal zebrafish development. Environ Toxicol Chem 2014;33:170–176. © 2013 SETAC</description><identifier>ISSN: 0730-7268</identifier><identifier>EISSN: 1552-8618</identifier><identifier>DOI: 10.1002/etc.2408</identifier><identifier>PMID: 24123209</identifier><identifier>CODEN: ETOCDK</identifier><language>eng</language><publisher>Pensacola, FL: Blackwell Publishing Ltd</publisher><subject>abnormal development ; Agnatha. Pisces ; Animal, plant and microbial ecology ; Animals ; Applied ecology ; Aquatic environment ; Arylsulfotransferase - genetics ; Biological and medical sciences ; brain ; Brain - drug effects ; Brain - metabolism ; chronic exposure ; Danio rerio ; Ecotoxicology, biological effects of pollution ; Effects of pollution and side effects of pesticides on vertebrates ; Endocrine disruptors ; environmental exposure ; Exposure ; Female ; fish ; Freshwater ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Genes ; Glucuronosyltransferase - genetics ; Hormones ; Hypothalamic-pituitary-thyroid axis ; Iodide Peroxidase - genetics ; Liver ; Liver - drug effects ; Liver - metabolism ; Male ; Males ; messenger RNA ; metabolism ; Offspring ; Pentachlorophenol ; Pentachlorophenol - toxicity ; prealbumin ; Prealbumin - genetics ; progeny ; RNA, Messenger - metabolism ; Signal transduction ; Thyroid ; Thyroid gland ; Thyroid hormone ; Thyroid Hormone Receptors beta - genetics ; thyroid hormones ; Thyroid Hormones - blood ; Thyrotropin, beta Subunit - genetics ; thyroxine ; uridine ; Water Pollutants, Chemical - toxicity ; Zebrafish ; Zebrafish - genetics ; Zebrafish - metabolism ; Zebrafish Proteins - genetics</subject><ispartof>Environmental toxicology and chemistry, 2014-01, Vol.33 (1), p.170-176</ispartof><rights>2013 SETAC</rights><rights>2015 INIST-CNRS</rights><rights>2013 SETAC.</rights><rights>Copyright Blackwell Publishing Ltd. Jan 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5448-c6439e42ed48dbcfceaf0d3aa340239b52cc4094d639c3473c02a28fec043e9c3</citedby><cites>FETCH-LOGICAL-c5448-c6439e42ed48dbcfceaf0d3aa340239b52cc4094d639c3473c02a28fec043e9c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fetc.2408$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fetc.2408$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28260039$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24123209$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Li‐Qin</creatorcontrib><creatorcontrib>Zhao, Gao‐Feng</creatorcontrib><creatorcontrib>Feng, Min</creatorcontrib><creatorcontrib>Wen, Wu</creatorcontrib><creatorcontrib>Li, Kun</creatorcontrib><creatorcontrib>Zhang, Pan‐Wei</creatorcontrib><creatorcontrib>Peng, Xi</creatorcontrib><creatorcontrib>Huo, Wei‐Jie</creatorcontrib><creatorcontrib>Zhou, Huai‐Dong</creatorcontrib><title>Chronic exposure to pentachlorophenol alters thyroid hormones and thyroid hormone pathway mRNAs in zebrafish</title><title>Environmental toxicology and chemistry</title><addtitle>Environ Toxicol Chem</addtitle><description>Pentachlorophenol (PCP) is frequently detected in the aquatic environment and has been implicated as an endocrine disruptor in fish. In the present study, 4‐month‐old zebrafish (Danio rerio) were exposed to 1 of 4 concentrations of PCP (0.1, 1, 9, and 27 µg/L) for 70 d. The effects of PCP exposure on plasma thyroid hormone levels, and the expression levels of selected genes, were measured in the brain and liver. The PCP exposure at 27 µg/L resulted in elevated plasma thyroxine concentrations in male and female zebrafish and depressed 3, 5, 3'‐triiodothyronine concentrations in males only. In both sexes, PCP exposure resulted in decreased messenger RNA (mRNA) expression levels of thyroid‐stimulating hormone β‐subunit (tshβ) and thyroid hormone receptor β (trβ) in the brain, as well as increased liver levels of uridine diphosphoglucuronosyl transferase (ugt1ab) and decreased deiodinase 1 (dio1). The authors also identified several sex‐specific effects of PCP exposure, including changes in mRNA levels for deiodinase 2 (dio2), cytosolic sulfotransferase (sult1 st5), and transthyretin (ttr) genes in the liver. Environmental PCP exposure also caused an increased malformation rate in offspring that received maternal exposure to PCP. The present study demonstrates that chronic exposure to environmental levels of PCP alters plasma thyroid hormone levels, as well as the expression of genes associated with thyroid hormone signaling and metabolism in the hypothalamic‐pituitary‐thyroid (HPT) axis and liver, resulting in abnormal zebrafish development. Environ Toxicol Chem 2014;33:170–176. © 2013 SETAC</description><subject>abnormal development</subject><subject>Agnatha. Pisces</subject><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Applied ecology</subject><subject>Aquatic environment</subject><subject>Arylsulfotransferase - genetics</subject><subject>Biological and medical sciences</subject><subject>brain</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>chronic exposure</subject><subject>Danio rerio</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Effects of pollution and side effects of pesticides on vertebrates</subject><subject>Endocrine disruptors</subject><subject>environmental exposure</subject><subject>Exposure</subject><subject>Female</subject><subject>fish</subject><subject>Freshwater</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Glucuronosyltransferase - genetics</subject><subject>Hormones</subject><subject>Hypothalamic-pituitary-thyroid axis</subject><subject>Iodide Peroxidase - genetics</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Males</subject><subject>messenger RNA</subject><subject>metabolism</subject><subject>Offspring</subject><subject>Pentachlorophenol</subject><subject>Pentachlorophenol - toxicity</subject><subject>prealbumin</subject><subject>Prealbumin - genetics</subject><subject>progeny</subject><subject>RNA, Messenger - metabolism</subject><subject>Signal transduction</subject><subject>Thyroid</subject><subject>Thyroid gland</subject><subject>Thyroid hormone</subject><subject>Thyroid Hormone Receptors beta - genetics</subject><subject>thyroid hormones</subject><subject>Thyroid Hormones - blood</subject><subject>Thyrotropin, beta Subunit - genetics</subject><subject>thyroxine</subject><subject>uridine</subject><subject>Water Pollutants, Chemical - toxicity</subject><subject>Zebrafish</subject><subject>Zebrafish - genetics</subject><subject>Zebrafish - metabolism</subject><subject>Zebrafish Proteins - genetics</subject><issn>0730-7268</issn><issn>1552-8618</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0VFr1TAUB_Agiru7Cn4CDYjgS-dpkibN47joFMcc1w19C7npqe1smy5p2e4-vb3cusFAfAocfvzPCX9CXqVwlAKwDzi4IyYgf0IWaZaxJJdp_pQsQHFIFJP5ATmM8QoglVrr5-SAiZRxBnpBmlUVfFc7ire9j2NAOnjaYzdYVzU--L7CzjfUNgOGSIdqG3xd0MqH1ncYqe2Kx0Pa26G6sVvars-OI607eoebYMs6Vi_Is9I2EV_O75Jcfvp4sfqcnH47-bI6Pk1cJkSeOCm4RsGwEHmxcaVDW0LBreUCGNebjDknQItCcu24UNwBsywv0YHgOI2W5P0-tw_-esQ4mLaODpvGdujHaFIpGGNKafg_FZpJDrvFS_L2Eb3yY-imj0xK8VyDzNhDoAs-xoCl6UPd2rA1KZhdWWYqy-zKmujrOXDctFjcw7_tTODdDGx0timD7VwdH1zOJADfuWTvbuoGt_9caCYzL559HQe8vfc2_DZScZWZH2cn5pzDz_Ov67W5mPybvS-tN_ZXmG64_M4gFQCQqQwy_gdXTcNc</recordid><startdate>201401</startdate><enddate>201401</enddate><creator>Yu, Li‐Qin</creator><creator>Zhao, Gao‐Feng</creator><creator>Feng, Min</creator><creator>Wen, Wu</creator><creator>Li, Kun</creator><creator>Zhang, Pan‐Wei</creator><creator>Peng, Xi</creator><creator>Huo, Wei‐Jie</creator><creator>Zhou, Huai‐Dong</creator><general>Blackwell Publishing Ltd</general><general>SETAC</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>SOI</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>7SU</scope><scope>KR7</scope></search><sort><creationdate>201401</creationdate><title>Chronic exposure to pentachlorophenol alters thyroid hormones and thyroid hormone pathway mRNAs in zebrafish</title><author>Yu, Li‐Qin ; Zhao, Gao‐Feng ; Feng, Min ; Wen, Wu ; Li, Kun ; Zhang, Pan‐Wei ; Peng, Xi ; Huo, Wei‐Jie ; Zhou, Huai‐Dong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5448-c6439e42ed48dbcfceaf0d3aa340239b52cc4094d639c3473c02a28fec043e9c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>abnormal development</topic><topic>Agnatha. Pisces</topic><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Applied ecology</topic><topic>Aquatic environment</topic><topic>Arylsulfotransferase - genetics</topic><topic>Biological and medical sciences</topic><topic>brain</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>chronic exposure</topic><topic>Danio rerio</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Effects of pollution and side effects of pesticides on vertebrates</topic><topic>Endocrine disruptors</topic><topic>environmental exposure</topic><topic>Exposure</topic><topic>Female</topic><topic>fish</topic><topic>Freshwater</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Glucuronosyltransferase - genetics</topic><topic>Hormones</topic><topic>Hypothalamic-pituitary-thyroid axis</topic><topic>Iodide Peroxidase - genetics</topic><topic>Liver</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Males</topic><topic>messenger RNA</topic><topic>metabolism</topic><topic>Offspring</topic><topic>Pentachlorophenol</topic><topic>Pentachlorophenol - toxicity</topic><topic>prealbumin</topic><topic>Prealbumin - genetics</topic><topic>progeny</topic><topic>RNA, Messenger - metabolism</topic><topic>Signal transduction</topic><topic>Thyroid</topic><topic>Thyroid gland</topic><topic>Thyroid hormone</topic><topic>Thyroid Hormone Receptors beta - genetics</topic><topic>thyroid hormones</topic><topic>Thyroid Hormones - blood</topic><topic>Thyrotropin, beta Subunit - genetics</topic><topic>thyroxine</topic><topic>uridine</topic><topic>Water Pollutants, Chemical - toxicity</topic><topic>Zebrafish</topic><topic>Zebrafish - genetics</topic><topic>Zebrafish - metabolism</topic><topic>Zebrafish Proteins - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Li‐Qin</creatorcontrib><creatorcontrib>Zhao, Gao‐Feng</creatorcontrib><creatorcontrib>Feng, Min</creatorcontrib><creatorcontrib>Wen, Wu</creatorcontrib><creatorcontrib>Li, Kun</creatorcontrib><creatorcontrib>Zhang, Pan‐Wei</creatorcontrib><creatorcontrib>Peng, Xi</creatorcontrib><creatorcontrib>Huo, Wei‐Jie</creatorcontrib><creatorcontrib>Zhou, Huai‐Dong</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Environmental Engineering Abstracts</collection><collection>Civil Engineering Abstracts</collection><jtitle>Environmental toxicology and chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Li‐Qin</au><au>Zhao, Gao‐Feng</au><au>Feng, Min</au><au>Wen, Wu</au><au>Li, Kun</au><au>Zhang, Pan‐Wei</au><au>Peng, Xi</au><au>Huo, Wei‐Jie</au><au>Zhou, Huai‐Dong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic exposure to pentachlorophenol alters thyroid hormones and thyroid hormone pathway mRNAs in zebrafish</atitle><jtitle>Environmental toxicology and chemistry</jtitle><addtitle>Environ Toxicol Chem</addtitle><date>2014-01</date><risdate>2014</risdate><volume>33</volume><issue>1</issue><spage>170</spage><epage>176</epage><pages>170-176</pages><issn>0730-7268</issn><eissn>1552-8618</eissn><coden>ETOCDK</coden><abstract>Pentachlorophenol (PCP) is frequently detected in the aquatic environment and has been implicated as an endocrine disruptor in fish. In the present study, 4‐month‐old zebrafish (Danio rerio) were exposed to 1 of 4 concentrations of PCP (0.1, 1, 9, and 27 µg/L) for 70 d. The effects of PCP exposure on plasma thyroid hormone levels, and the expression levels of selected genes, were measured in the brain and liver. The PCP exposure at 27 µg/L resulted in elevated plasma thyroxine concentrations in male and female zebrafish and depressed 3, 5, 3'‐triiodothyronine concentrations in males only. In both sexes, PCP exposure resulted in decreased messenger RNA (mRNA) expression levels of thyroid‐stimulating hormone β‐subunit (tshβ) and thyroid hormone receptor β (trβ) in the brain, as well as increased liver levels of uridine diphosphoglucuronosyl transferase (ugt1ab) and decreased deiodinase 1 (dio1). The authors also identified several sex‐specific effects of PCP exposure, including changes in mRNA levels for deiodinase 2 (dio2), cytosolic sulfotransferase (sult1 st5), and transthyretin (ttr) genes in the liver. Environmental PCP exposure also caused an increased malformation rate in offspring that received maternal exposure to PCP. The present study demonstrates that chronic exposure to environmental levels of PCP alters plasma thyroid hormone levels, as well as the expression of genes associated with thyroid hormone signaling and metabolism in the hypothalamic‐pituitary‐thyroid (HPT) axis and liver, resulting in abnormal zebrafish development. Environ Toxicol Chem 2014;33:170–176. © 2013 SETAC</abstract><cop>Pensacola, FL</cop><pub>Blackwell Publishing Ltd</pub><pmid>24123209</pmid><doi>10.1002/etc.2408</doi><tpages>7</tpages></addata></record> |
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| ispartof | Environmental toxicology and chemistry, 2014-01, Vol.33 (1), p.170-176 |
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| subjects | abnormal development Agnatha. Pisces Animal, plant and microbial ecology Animals Applied ecology Aquatic environment Arylsulfotransferase - genetics Biological and medical sciences brain Brain - drug effects Brain - metabolism chronic exposure Danio rerio Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates Endocrine disruptors environmental exposure Exposure Female fish Freshwater Fundamental and applied biological sciences. Psychology Gene expression Genes Glucuronosyltransferase - genetics Hormones Hypothalamic-pituitary-thyroid axis Iodide Peroxidase - genetics Liver Liver - drug effects Liver - metabolism Male Males messenger RNA metabolism Offspring Pentachlorophenol Pentachlorophenol - toxicity prealbumin Prealbumin - genetics progeny RNA, Messenger - metabolism Signal transduction Thyroid Thyroid gland Thyroid hormone Thyroid Hormone Receptors beta - genetics thyroid hormones Thyroid Hormones - blood Thyrotropin, beta Subunit - genetics thyroxine uridine Water Pollutants, Chemical - toxicity Zebrafish Zebrafish - genetics Zebrafish - metabolism Zebrafish Proteins - genetics |
| title | Chronic exposure to pentachlorophenol alters thyroid hormones and thyroid hormone pathway mRNAs in zebrafish |
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