Nanoscale characterization of DNA conformation using dual-color fluorescence axial localization and label-free biosensing

Quantitative determination of the density and conformation of DNA molecules tethered to the surface can help optimize and understand DNA nanosensors and nanodevices, which use conformational or motional changes of surface-immobilized DNA for detection or actuation. We present an interferometric sens...

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Veröffentlicht in:	Analyst (London) 2014-12, Vol.139 (24), p.6440-6449
Hauptverfasser:	Zhang, Xirui, Daaboul, George G, Spuhler, Philipp S, Freedman, David S, Yurt, Abdulkadir, Ahn, Sunmin, Avci, Oguzhan, Ünlü, M Selim
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Biomolecules Biosensing Techniques - instrumentation Density Deoxyribonucleic acid Equipment Design Fluorescence Fluorescent Dyes - analysis Immobilized Nucleic Acids - analysis Nanostructure Nanostructures - chemistry Nucleic Acid Conformation Platforms Polymers - chemistry Spectrometry, Fluorescence - instrumentation Three dimensional
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