High-sensitivity C-reactive protein as a novel marker in early diagnosis of ovarian torsion: an experimental study
Absract Objective To investigate the effect of ovarian torsion on plasma high-sensitivity Creactive protein (hs-CRP) levels and to determine whether hs-CRP levels were a useful adjunct that could be used in the diagnosis of ovarian torsion. Materials and methods Sixteen nulligravid 4-month-old femal...
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| Veröffentlicht in: | Archives of gynecology and obstetrics 2015-01, Vol.291 (1), p.99-104 |
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| container_title | Archives of gynecology and obstetrics |
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| creator | Bakacak, Murat Köstü, Bülent Ercan, Önder Bostancı, Mehmet Sühha Kıran, Gürkan Aral, Murat Çıralık, Harun Serin, Salih |
| description | Absract
Objective
To investigate the effect of ovarian torsion on plasma high-sensitivity Creactive protein (hs-CRP) levels and to determine whether hs-CRP levels were a useful adjunct that could be used in the diagnosis of ovarian torsion.
Materials and methods
Sixteen nulligravid 4-month-old female Wistar albino rats were randomly and equally allocated into two groups. Control group, sham operation (
n
= 8) group, and study group, ovarian torsion (
n
= 8) group. Ovarian torsion model was created using titanium vascular clips and vascular clips were kept for a 2-h period. Right ovaries were surgically removed at the end of the procedure in each group. Blood was sampled before and after operation to assess plasma hs-CRP levels. Ovarian histopathologic findings scores and plasma hs-CRP levels were evaluated.
Results
In study group, the mean plasma hs-CRP level was significantly higher than that in the control group. (0.91 ± 0.18 vs. 0.39 ± 0.06 mg/l, respectively,
p
|
| doi_str_mv | 10.1007/s00404-014-3400-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1642188101</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2261878295</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-7d54676643235ba8f9478492afa6ce9b285a1a6e3acec275f979bef6e5401d13</originalsourceid><addsrcrecordid>eNp1kUFvEzEQhS1ERUPhB3BBlrhwMR17vbaXG4qAIlXqpXdrsjsbXDZ2sHcj8u_rKAUkJE4ee755nqfH2BsJHySAvS4AGrQAqUWjAYR7xlZSN0qAlfI5W0F3qsHYS_aylAcAqZwzL9ilasF0RrsVyzdh-10UiiXM4RDmI1-LTNjXC_F9TjOFyLFw5DEdaOI7zD8o8_pImKcjHwJuYyqh8DTydMAcMPI55RJS_MhrTb_2lMOO4owTL_MyHF-xixGnQq-fzit2_-Xz_fpG3N59_bb-dCt6rdUs7NBqY42pfpp2g27stHW6Uzii6anbKNeiREMN9tQr246d7TY0Gmo1yEE2V-z9Wba6-LlQmf0ulJ6mCSOlpXhptJLOSTih7_5BH9KSY13OK2Wks051baXkmepzKiXT6PfVGOajl-BPefhzHr7m4U95eFdn3j4pL5sdDX8mfgdQAXUGSm3FLeW_X_9f9RHH8ZYM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2261878295</pqid></control><display><type>article</type><title>High-sensitivity C-reactive protein as a novel marker in early diagnosis of ovarian torsion: an experimental study</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Bakacak, Murat ; Köstü, Bülent ; Ercan, Önder ; Bostancı, Mehmet Sühha ; Kıran, Gürkan ; Aral, Murat ; Çıralık, Harun ; Serin, Salih</creator><creatorcontrib>Bakacak, Murat ; Köstü, Bülent ; Ercan, Önder ; Bostancı, Mehmet Sühha ; Kıran, Gürkan ; Aral, Murat ; Çıralık, Harun ; Serin, Salih</creatorcontrib><description>Absract
Objective
To investigate the effect of ovarian torsion on plasma high-sensitivity Creactive protein (hs-CRP) levels and to determine whether hs-CRP levels were a useful adjunct that could be used in the diagnosis of ovarian torsion.
Materials and methods
Sixteen nulligravid 4-month-old female Wistar albino rats were randomly and equally allocated into two groups. Control group, sham operation (
n
= 8) group, and study group, ovarian torsion (
n
= 8) group. Ovarian torsion model was created using titanium vascular clips and vascular clips were kept for a 2-h period. Right ovaries were surgically removed at the end of the procedure in each group. Blood was sampled before and after operation to assess plasma hs-CRP levels. Ovarian histopathologic findings scores and plasma hs-CRP levels were evaluated.
Results
In study group, the mean plasma hs-CRP level was significantly higher than that in the control group. (0.91 ± 0.18 vs. 0.39 ± 0.06 mg/l, respectively,
p
< 0.001), following 2 h of ovarian torsion. Histologic examinations of the right ovary confirmed the torsion model. Histologic score of the specimens had higher scores for follicular cell degeneration (
p
= 0.002), vascular congestion (
p
= 0.002), inflammatory cell infiltration (
p
= 0.003), and hemorrhage (
p
< 0.001) in the study group. For the change in the plasma hs-CRP value for a cut-off value of >0.275 mg/l, sensitivity and specificity were calculated as 100 %.
Conclusion
The measurement of hs-CRP in a rat model seems to be a valuable plasma marker in early detection and diagnosis of ovarian torsion. However, further clinical and experimental studies of a larger size are required.</description><identifier>ISSN: 0932-0067</identifier><identifier>EISSN: 1432-0711</identifier><identifier>DOI: 10.1007/s00404-014-3400-8</identifier><identifier>PMID: 25069648</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; Biomarkers - blood ; C-Reactive Protein - metabolism ; Early Diagnosis ; Endocrinology ; Female ; General Gynecology ; Gynecology ; Human Genetics ; Medicine ; Medicine & Public Health ; Obstetrics/Perinatology/Midwifery ; Ovarian Diseases - diagnosis ; Ovarian Diseases - pathology ; Plasma ; Rats ; Rats, Wistar ; Torsion Abnormality - diagnosis ; Torsion Abnormality - pathology</subject><ispartof>Archives of gynecology and obstetrics, 2015-01, Vol.291 (1), p.99-104</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>Archives of Gynecology and Obstetrics is a copyright of Springer, (2014). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-7d54676643235ba8f9478492afa6ce9b285a1a6e3acec275f979bef6e5401d13</citedby><cites>FETCH-LOGICAL-c442t-7d54676643235ba8f9478492afa6ce9b285a1a6e3acec275f979bef6e5401d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00404-014-3400-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00404-014-3400-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25069648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bakacak, Murat</creatorcontrib><creatorcontrib>Köstü, Bülent</creatorcontrib><creatorcontrib>Ercan, Önder</creatorcontrib><creatorcontrib>Bostancı, Mehmet Sühha</creatorcontrib><creatorcontrib>Kıran, Gürkan</creatorcontrib><creatorcontrib>Aral, Murat</creatorcontrib><creatorcontrib>Çıralık, Harun</creatorcontrib><creatorcontrib>Serin, Salih</creatorcontrib><title>High-sensitivity C-reactive protein as a novel marker in early diagnosis of ovarian torsion: an experimental study</title><title>Archives of gynecology and obstetrics</title><addtitle>Arch Gynecol Obstet</addtitle><addtitle>Arch Gynecol Obstet</addtitle><description>Absract
Objective
To investigate the effect of ovarian torsion on plasma high-sensitivity Creactive protein (hs-CRP) levels and to determine whether hs-CRP levels were a useful adjunct that could be used in the diagnosis of ovarian torsion.
Materials and methods
Sixteen nulligravid 4-month-old female Wistar albino rats were randomly and equally allocated into two groups. Control group, sham operation (
n
= 8) group, and study group, ovarian torsion (
n
= 8) group. Ovarian torsion model was created using titanium vascular clips and vascular clips were kept for a 2-h period. Right ovaries were surgically removed at the end of the procedure in each group. Blood was sampled before and after operation to assess plasma hs-CRP levels. Ovarian histopathologic findings scores and plasma hs-CRP levels were evaluated.
Results
In study group, the mean plasma hs-CRP level was significantly higher than that in the control group. (0.91 ± 0.18 vs. 0.39 ± 0.06 mg/l, respectively,
p
< 0.001), following 2 h of ovarian torsion. Histologic examinations of the right ovary confirmed the torsion model. Histologic score of the specimens had higher scores for follicular cell degeneration (
p
= 0.002), vascular congestion (
p
= 0.002), inflammatory cell infiltration (
p
= 0.003), and hemorrhage (
p
< 0.001) in the study group. For the change in the plasma hs-CRP value for a cut-off value of >0.275 mg/l, sensitivity and specificity were calculated as 100 %.
Conclusion
The measurement of hs-CRP in a rat model seems to be a valuable plasma marker in early detection and diagnosis of ovarian torsion. However, further clinical and experimental studies of a larger size are required.</description><subject>Animals</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - metabolism</subject><subject>Early Diagnosis</subject><subject>Endocrinology</subject><subject>Female</subject><subject>General Gynecology</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Ovarian Diseases - diagnosis</subject><subject>Ovarian Diseases - pathology</subject><subject>Plasma</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Torsion Abnormality - diagnosis</subject><subject>Torsion Abnormality - pathology</subject><issn>0932-0067</issn><issn>1432-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kUFvEzEQhS1ERUPhB3BBlrhwMR17vbaXG4qAIlXqpXdrsjsbXDZ2sHcj8u_rKAUkJE4ee755nqfH2BsJHySAvS4AGrQAqUWjAYR7xlZSN0qAlfI5W0F3qsHYS_aylAcAqZwzL9ilasF0RrsVyzdh-10UiiXM4RDmI1-LTNjXC_F9TjOFyLFw5DEdaOI7zD8o8_pImKcjHwJuYyqh8DTydMAcMPI55RJS_MhrTb_2lMOO4owTL_MyHF-xixGnQq-fzit2_-Xz_fpG3N59_bb-dCt6rdUs7NBqY42pfpp2g27stHW6Uzii6anbKNeiREMN9tQr246d7TY0Gmo1yEE2V-z9Wba6-LlQmf0ulJ6mCSOlpXhptJLOSTih7_5BH9KSY13OK2Wks051baXkmepzKiXT6PfVGOajl-BPefhzHr7m4U95eFdn3j4pL5sdDX8mfgdQAXUGSm3FLeW_X_9f9RHH8ZYM</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Bakacak, Murat</creator><creator>Köstü, Bülent</creator><creator>Ercan, Önder</creator><creator>Bostancı, Mehmet Sühha</creator><creator>Kıran, Gürkan</creator><creator>Aral, Murat</creator><creator>Çıralık, Harun</creator><creator>Serin, Salih</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20150101</creationdate><title>High-sensitivity C-reactive protein as a novel marker in early diagnosis of ovarian torsion: an experimental study</title><author>Bakacak, Murat ; Köstü, Bülent ; Ercan, Önder ; Bostancı, Mehmet Sühha ; Kıran, Gürkan ; Aral, Murat ; Çıralık, Harun ; Serin, Salih</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-7d54676643235ba8f9478492afa6ce9b285a1a6e3acec275f979bef6e5401d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein - metabolism</topic><topic>Early Diagnosis</topic><topic>Endocrinology</topic><topic>Female</topic><topic>General Gynecology</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Ovarian Diseases - diagnosis</topic><topic>Ovarian Diseases - pathology</topic><topic>Plasma</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Torsion Abnormality - diagnosis</topic><topic>Torsion Abnormality - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bakacak, Murat</creatorcontrib><creatorcontrib>Köstü, Bülent</creatorcontrib><creatorcontrib>Ercan, Önder</creatorcontrib><creatorcontrib>Bostancı, Mehmet Sühha</creatorcontrib><creatorcontrib>Kıran, Gürkan</creatorcontrib><creatorcontrib>Aral, Murat</creatorcontrib><creatorcontrib>Çıralık, Harun</creatorcontrib><creatorcontrib>Serin, Salih</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bakacak, Murat</au><au>Köstü, Bülent</au><au>Ercan, Önder</au><au>Bostancı, Mehmet Sühha</au><au>Kıran, Gürkan</au><au>Aral, Murat</au><au>Çıralık, Harun</au><au>Serin, Salih</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High-sensitivity C-reactive protein as a novel marker in early diagnosis of ovarian torsion: an experimental study</atitle><jtitle>Archives of gynecology and obstetrics</jtitle><stitle>Arch Gynecol Obstet</stitle><addtitle>Arch Gynecol Obstet</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>291</volume><issue>1</issue><spage>99</spage><epage>104</epage><pages>99-104</pages><issn>0932-0067</issn><eissn>1432-0711</eissn><abstract>Absract
Objective
To investigate the effect of ovarian torsion on plasma high-sensitivity Creactive protein (hs-CRP) levels and to determine whether hs-CRP levels were a useful adjunct that could be used in the diagnosis of ovarian torsion.
Materials and methods
Sixteen nulligravid 4-month-old female Wistar albino rats were randomly and equally allocated into two groups. Control group, sham operation (
n
= 8) group, and study group, ovarian torsion (
n
= 8) group. Ovarian torsion model was created using titanium vascular clips and vascular clips were kept for a 2-h period. Right ovaries were surgically removed at the end of the procedure in each group. Blood was sampled before and after operation to assess plasma hs-CRP levels. Ovarian histopathologic findings scores and plasma hs-CRP levels were evaluated.
Results
In study group, the mean plasma hs-CRP level was significantly higher than that in the control group. (0.91 ± 0.18 vs. 0.39 ± 0.06 mg/l, respectively,
p
< 0.001), following 2 h of ovarian torsion. Histologic examinations of the right ovary confirmed the torsion model. Histologic score of the specimens had higher scores for follicular cell degeneration (
p
= 0.002), vascular congestion (
p
= 0.002), inflammatory cell infiltration (
p
= 0.003), and hemorrhage (
p
< 0.001) in the study group. For the change in the plasma hs-CRP value for a cut-off value of >0.275 mg/l, sensitivity and specificity were calculated as 100 %.
Conclusion
The measurement of hs-CRP in a rat model seems to be a valuable plasma marker in early detection and diagnosis of ovarian torsion. However, further clinical and experimental studies of a larger size are required.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25069648</pmid><doi>10.1007/s00404-014-3400-8</doi><tpages>6</tpages></addata></record> |
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| issn | 0932-0067 1432-0711 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Biomarkers - blood C-Reactive Protein - metabolism Early Diagnosis Endocrinology Female General Gynecology Gynecology Human Genetics Medicine Medicine & Public Health Obstetrics/Perinatology/Midwifery Ovarian Diseases - diagnosis Ovarian Diseases - pathology Plasma Rats Rats, Wistar Torsion Abnormality - diagnosis Torsion Abnormality - pathology |
| title | High-sensitivity C-reactive protein as a novel marker in early diagnosis of ovarian torsion: an experimental study |
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